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From different, but complementary perspectives, and taking advantage of advanced specialized methods, the biomedical research disciplines of Physiology and Biophysics seek to discover, analyze and explain the functions of the human body’s building blocks: cells, tissues and organs. The availability of information from genomics, imaging, and proteomics, combined with the power of computational methods, has enabled entirely new approaches for making these discoveries and relating them to the most basic molecular mechanisms. Most importantly, these new approaches make it possible to integrate, in the research activities of the Program’s faculty, the findings from genetics, structural biology, and cell and molecular biology with principles and representations from physics and engineering.