Lawrence Palmer, Ph.D.

Professor of Physiology and Biophysics

  • Thomas H. Meikle Jr., Professor of Medical Education


1300 York Avenue, Room C-501 C
New York, NY 10065


Research Areas

Research Summary:

The Palmer lab studies the mechanisms of epithelial ion transport and its regulation by hormones and other factors.  Part of this research is at the molecular level.  Here we identify ion channel proteins that mediate the movement of Na+and K+into or out of epithelial cells, and explore the aspects of those proteins that confer the properties of ion conduction and selectivity for the cognate ion.  Epithelial Na+channels (ENaCs) for example, are exquisitely selective for Na+over K+but the basis for that selectivity is not well understood.




Experimental techniques include electrophysiology, both whole-cell and single-channel, heterologous expression systems and site-directed mutagenesis. A second line of investigation explores the processes that regulate these channels in cells, organs and whole animals. Here a fundamental question is how the kidneys adapt to changes in dietary intake to maintain constant concentrations and amounts of electrolytes in extracellular fluids. Here we look at changes in channel number, location and function in kidney cells under varying physiological conditions. Tools include electrophysiology, Western blotting and RNA sequencing, together with genetically modified animal models. Finally, we are beginning to explore interactions between different segments of the nephron that express different ion transporters in the maintenance of electrolyte homeostasis.


Recent Publications:

  1. Palmer, LG. Directing two-way traffic in the kidney: A tale of two ions. J Gen Physiol. 2022;154 (10):. doi: 10.1085/jgp.202213179. PubMed PMID:36048011 PubMed Central PMC9437110.
  2. Frindt, G, Meyerson, JR, Satty, A, Scandura, JM, Palmer, LG. Expression of ENaC subunits in epithelia. J Gen Physiol. 2022;154 (10):. doi: 10.1085/jgp.202213124. PubMed PMID:35939271 PubMed Central PMC9387651.
  3. Xu, S, Li, J, Yang, L, Wang, CJ, Liu, T, Weinstein, AM et al.. Sex difference in kidney electrolyte transport III: Impact of low K intake on thiazide-sensitive cation excretion in male and female mice. Pflugers Arch. 2021;473 (11):1749-1760. doi: 10.1007/s00424-021-02611-5. PubMed PMID:34455480 PubMed Central PMC8528772.
  4. Yang, L, Xu, Y, Gravotta, D, Frindt, G, Weinstein, AM, Palmer, LG et al.. ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion. J Gen Physiol. 2021;153 (8):. doi: 10.1085/jgp.202112902. PubMed PMID:34143184 PubMed Central PMC8217949.
  5. Frindt, G, Shi, S, Kleyman, TR, Palmer, LG. Cleavage state of γENaC in mouse and rat kidneys. Am J Physiol Renal Physiol. 2021;320 (3):F485-F491. doi: 10.1152/ajprenal.00536.2020. PubMed PMID:33522411 PubMed Central PMC7988816.
  6. Palmer, LG. Are Some Nephrons More Equal Than Others?: Perspective on "Viewing Cortical Collecting Duct Function Through Phenotype-Guided Single-Tubule Proteomics". Function (Oxf). 2020;1 (1):zqaa010. doi: 10.1093/function/zqaa010. PubMed PMID:35330744 PubMed Central PMC8788712.
  7. Yang, L, Frindt, G, Xu, Y, Uchida, S, Palmer, LG. Aldosterone-dependent and -independent regulation of Na+ and K+ excretion and ENaC in mouse kidneys. Am J Physiol Renal Physiol. 2020;319 (2):F323-F334. doi: 10.1152/ajprenal.00204.2020. PubMed PMID:32628540 PubMed Central PMC7473898.
  8. Frindt, G, Bertog, M, Korbmacher, C, Palmer, LG. Ubiquitination of renal ENaC subunits in vivo. Am J Physiol Renal Physiol. 2020;318 (5):F1113-F1121. doi: 10.1152/ajprenal.00609.2019. PubMed PMID:32174140 PubMed Central PMC7294337.
  9. Li, J, Xu, S, Yang, L, Yang, J, Wang, CJ, Weinstein, AM et al.. Sex difference in kidney electrolyte transport II: impact of K+ intake on thiazide-sensitive cation excretion in male and female mice. Am J Physiol Renal Physiol. 2019;317 (4):F967-F977. doi: 10.1152/ajprenal.00125.2019. PubMed PMID:31390232 PubMed Central PMC6843050.
  10. Yang, L, Palmer, LG. Determinants of selective ion permeation in the epithelial Na+ channel. J Gen Physiol. 2018;150 (10):1397-1407. doi: 10.1085/jgp.201812164. PubMed PMID:30135076 PubMed Central PMC6168236.
  11. Yang, L, Xu, S, Guo, X, Uchida, S, Weinstein, AM, Wang, T et al.. Regulation of renal Na transporters in response to dietary K. Am J Physiol Renal Physiol. 2018;315 (4):F1032-F1041. doi: 10.1152/ajprenal.00117.2018. PubMed PMID:29923764 PubMed Central PMC6230734.
  12. Frindt, G, Yang, L, Bamberg, K, Palmer, LG. Na restriction activates epithelial Na channels in rat kidney through two mechanisms and decreases distal Na+ delivery. J Physiol. 2018;596 (16):3585-3602. doi: 10.1113/JP275988. PubMed PMID:29737520 PubMed Central PMC6092292.
  13. Palmer, LG. Epithelial transport in The Journal of General Physiology. J Gen Physiol. 2017;149 (10):897-909. doi: 10.1085/jgp.201711828. PubMed PMID:28931633 PubMed Central PMC5688356.
  14. Li, J, Hatano, R, Xu, S, Wan, L, Yang, L, Weinstein, AM et al.. Gender difference in kidney electrolyte transport. I. Role of AT1a receptor in thiazide-sensitive Na+-Cl- cotransporter activity and expression in male and female mice. Am J Physiol Renal Physiol. 2017;313 (2):F505-F513. doi: 10.1152/ajprenal.00087.2017. PubMed PMID:28566500 PubMed Central PMC5582908.
  15. Frindt, G, Yang, L, Uchida, S, Weinstein, AM, Palmer, LG. Responses of distal nephron Na+ transporters to acute volume depletion and hyperkalemia. Am J Physiol Renal Physiol. 2017;313 (1):F62-F73. doi: 10.1152/ajprenal.00668.2016. PubMed PMID:28356292 PubMed Central PMC5538837.
  16. Yang, L, Frindt, G, Lang, F, Kuhl, D, Vallon, V, Palmer, LG et al.. SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone. Am J Physiol Renal Physiol. 2017;312 (1):F65-F76. doi: 10.1152/ajprenal.00257.2016. PubMed PMID:27413200 PubMed Central PMC5283884.
  17. Ergonul, Z, Yang, L, Palmer, LG. Properties of acid-induced currents in mouse dorsal root ganglia neurons. Physiol Rep. 2016;4 (9):. doi: 10.14814/phy2.12795. PubMed PMID:27173673 PubMed Central PMC4873640.
  18. Frindt, G, Gravotta, D, Palmer, LG. Regulation of ENaC trafficking in rat kidney. J Gen Physiol. 2016;147 (3):217-27. doi: 10.1085/jgp.201511533. PubMed PMID:26880754 PubMed Central PMC4772376.
  19. Palmer, LG. Piece treaties connect ENaC subunits. Channels (Austin). 2015;9 (5):223-4. doi: 10.1080/19336950.2015.1092843. PubMed PMID:26542626 PubMed Central PMC4826115.
  20. Frindt, G, Palmer, LG. Acute effects of aldosterone on the epithelial Na channel in rat kidney. Am J Physiol Renal Physiol. 2015;308 (6):F572-8. doi: 10.1152/ajprenal.00585.2014. PubMed PMID:25520012 PubMed Central PMC4360037.
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