Dietrich Busselberg, Ph.D.

Professor of Physiology and Biophysics

  • Assistant Dean for Foundational Sciences at WCM-Q
  • Assistant Dean for Premedical Student Affairs at WCM-Q


Location: WCM Qatar


Research Areas

Research Summary:

  • Role of calcium signaling in cancer incidence, progression and resistance 
  • Overcoming chemo-resistance in Triple Negative Breast Cancers and Neuroblastoma 
  • Establishing the link between diabetes and breast cancer 


Selected Publications:

  1. Abotaleb M, Kubatka P, Caprnda M, Varghese E, Zolakova B, Zubor P, Opatrilova R, Kruzliak P, Stefanicka P, Busselberg D. Chemotherapeutic agents for the treatment of metastatic breast cancer: An update. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 May; 101:458. PMID: 29501768.
  2. Caprnda M, Kubatka P, Gazdikova K, Gasparova I, Valentova V, Stollarova N, La Rocca G, Kobyliak N, Dragasek J, Mozos I, Prosecky R, Siniscalco D, Busselberg D, Rodrigo L, Kruzliak P. Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jul; 91:60. PMID: 28448871.
  3. Elsheikha H, Busselberg D, Zhu X. The known and missing links between Toxoplasma gondii and schizophrenia. Metabolic brain disease. 2016 Apr. PMID: 27041387.
  4. Fedotova J, Barishpolec V, Zulli A, Büsselberg D, Gaspar L, Kruzliak P. Effects of acute or chronic administration of novel 3,4-dimethoxyphenylethylamine derivates on anxiety-like behavior. Am J Transl Res. 2015 Nov 15;7(11):2462-73. eCollection 2015. PubMed PMID: 26807191; PubMed Central PMCID: PMC4697723.
  5. Fedotova J, Kubatka P, Busselberg D, Shleikin A, Caprnda M, Dragasek J, Rodrigo L, Pohanka M, Gasparova I, Nosal V, Opatrilova R, Qaradakhi T, Zulli A, Kruzliak P. Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plant extracts. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95:437. PMID: 28863384.
  6. Florea A, Varghese E, McCallum J, Mahgoub S, Helmy I, Varghese S, Gopinath N, Sass S, Theis F, Reifenberger G, Busselberg D. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget. 2017 Jan; 8(14):22876. PMID: 28206967. PMCID: PMC5410270.
  7. Kapinova A, Stefanicka P, Kubatka P, Zubor P, Uramova S, Kello M, Mojžiš J, Blahutova D, Qaradakhi T, Zulli A, Caprnda M, Danko J, Lasabova Z, Busselberg D, Kruzliak P. Are plant-based functional foods better choice against cancer than single phytochemicals? A critical review of current breast cancer research. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jan.
  8. Kubatka P, Kello M, Kajo K, Kruzliak P, Výbohová D, Mojžiš J, Adamkov M, Fialová S, Veizerová L, Zulli A, Péč M, Statelová D, Grančai D, Büsselberg D. Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma  model. Eur J Nutr. 2017 Apr;56(3):1303-1316. doi: 10.1007/s00394-016-1181-5. Epub 2016 Feb 23. PubMed PMID: 26907089.
  9. Kubatka P, Zubor P, Busselberg D, Kwon T, Adamek M, Petrovic D, Opatrilova R, Gazdikova K, Caprnda M, Rodrigo L, Danko J, Kruzliak P. Melatonin and breast cancer: Evidences from preclinical and human studies. Critical reviews in oncology/hematology. 2018 Feb; 122:133. PMID: 29458781.
  10. Mytsyk Y, Dosenko V, Borys Y, Kucher A, Gazdikova K, Busselberg D, Caprnda M, Kruzliak P, Farooqi A, Lubov M. MicroRNA-15a expression measured in urine samples as a potential biomarker of renal cell carcinoma. International urology and nephrology. 2018 Mar; 1. PMID: 29549624.
  11. Opatrilova R, Caprnda M, Kubatka P, Valentova V, Uramova S, Nosal V, Gaspar L, Zachar L, Mozos I, Petrovic D, Dragasek J, Filipova S, Büsselberg D, Zulli A, Rodrigo L, Kruzliak P, Krasnik V. Adipokines in neurovascular diseases. Biomed Pharmacother. 2018 Feb;98:424-432. doi: 10.1016/j.biopha.2017.12.074. Epub 2017 Dec 27. Review. PubMed PMID: 29278852.
  12. Opatrilova R, Kubatka P, Caprnda M, Busselberg D, Krasnik V, Vesely P, Saxena S, Ruia S, Mozos I, Rodrigo L, Kruzliak P, dos Santos K. Nitric oxide in the pathophysiology of retinopathy: Evidences from preclinical and clinical researches. Acta ophthalmologica. 2017 Jan. PMID: 28391624.
  13. Rathore R, McCallum J, Varghese E, Florea A, Busselberg D. Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs). Apoptosis : an international journal on programmed cell death. 2017 Jul; 22(7):898. PMID: 28424988. PMCID: PMC5486846.
  14. Salamon S, Podbregar E, Kubatka P, Busselberg D, Caprnda M, Opatrilova R, Valentova V, Adamek M, Kruzliak P, Podbregar M. Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect. Nutrition and cancer. 2017 Feb; 69(2):177. PMID: 28094552.
  15. Samuel SM, Varghese E, Varghese S, Büsselberg D. Challenges and perspectives in the treatment of diabetes associated breast cancer. Cancer Treat Rev. 2018 Aug 10;70:98-111. doi: 10.1016/j.ctrv.2018.08.004. [Epub ahead of print] Review. PubMed PMID: 30130687.
  16. Satheesh NJ, Büsselberg D. The role of intracellular calcium for the development and treatment of neuroblastoma. Cancers (Basel). 2015 May 22;7(2):823-48. doi: 10.3390/cancers7020811. Review. PubMed PMID: 26010602; PubMed Central PMCID: PMC4491686.
  17. Satheesh NJ, Uehara Y, Fedotova J, Pohanka M, Büsselberg D, Kruzliak P. TRPV currents and their role in the nociception and neuroplasticity. Neuropeptides. 2016 Jun;57:1-8. doi: 10.1016/j.npep.2016.01.003. Epub 2016 Jan 13. Review. PubMed PMID: 26825374.
  18. Scheer M, Bischoff A, Kruzliak P, Opatrilova R, Bovell D, Busselberg D. Creatine and creatine pyruvate reduce hypoxia-induced effects on phrenic nerve activity in the juvenile mouse respiratory system. Experimental and molecular pathology. 2016 Aug; 101(1):157. PMID: 27450651.
  19. Varinska L, Kubatka P, Mojžiš J, Zulli A, Gazdikova K, Zubor P, Busselberg D, Caprnda M, Opatrilova R, Gasparova I, Klabusay M, Péč M, Fibach E, Adamek M, Kruzliak P. Angiomodulators in cancer therapy: New perspectives. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 May; 89:578. PMID: 28258040.
  20. Varghese S, Kubatka P, Rodrigo L, Gazdikova K, Caprnda M, Fedotova J, Zulli A, Kruzliak P, Busselberg D. Chili pepper as a body weight-loss food. International journal of food sciences and nutrition. 2017 May; 68(4):392. PMID: 27899046.