Christopher Mason, Ph.D.

Associate Professor of Physiology and Biophysics

  • Director, WorldQuant Initiative for Quantitative Prediction and WorldQuant Foundation Research Scholar
  • Associate Professor of Computational Genomics in Computational Biomedicinein the Institute for Computational Biomedicine
  • Associate Professor of Neuroscience, Brain and Mind Institute (secondary appointment)

646-962-5643

1305 York Avenue, Room Y-13.15
New York, NY 10021


Research Areas


Research Summary:

We utilize computational and experimental methodologies to identify and characterize the essential genetic elements that guide the function of the human genome, with a particular emphasis on the elements that orchestrate the development of the human brain. Our lab creates detailed cell-specific molecular maps of genetic, epigenetic, transcriptional, and translational activity, creating a draft of the molecular recipe for the creation of the brain. We also develop methods to detect, catalog and functionally annotate variants in the genetic pathways that control developmental processes and how they are perturbed to create disease. We aim to understand of the functional elements of the human genome well enough to enable, eventually, the ability to repair, re-engineer, or fortify these genetic networks within human cells.

Recent Publications:

  1. Cho, A, Eidelberg, A, Butler, DJ, Danko, D, Afshinnekoo, E, Mason, CE et al.. Efficacy of Daily Intake of Dried Cranberry 500 mg in Women with Overactive Bladder: A Randomized, Double-Blind, Placebo-Controlled Study. J. Urol. 2020; :101097JU0000000000001384. doi: 10.1097/JU.0000000000001384. PubMed PMID:32945735 .
  2. Li, S, Chen, X, Wang, J, Meydan, C, Glass, JL, Shih, AH et al.. Somatic mutations drive specific, but reversible epigenetic heterogeneity states in AML. Cancer Discov. 2020; :. doi: 10.1158/2159-8290.CD-19-0897. PubMed PMID:32938585 .
  3. Henssen, AG, Koche, R, Zhuang, J, Jiang, E, Reed, C, Eisenberg, A et al.. Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors. Nat. Genet. 2020; :. doi: 10.1038/s41588-020-00711-z. PubMed PMID:32918070 .
  4. Bharadwaj, AR, Daudu, R, Singh, NK, Wood, JM, Debieu, M, O'Hara, NB et al.. Draft Genome Sequences of Enterobacteriales Strains Isolated from the International Space Station. Microbiol Resour Announc. 2020;9 (37):. doi: 10.1128/MRA.00817-20. PubMed PMID:32912916 .
  5. Kawabata, KC, Zong, H, Meydan, C, Wyman, S, Wouters, BJ, Sugita, M et al.. BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells. Blood. 2020; :. doi: 10.1182/blood.2019001745. PubMed PMID:32911532 .
  6. Walker, JM, Garcet, S, Aleman, JO, Mason, CE, Danko, D, Zuffa, S et al.. Obesity and ethnicity alter gene expression in skin. Sci Rep. 2020;10 (1):14079. doi: 10.1038/s41598-020-70244-2. PubMed PMID:32826922 PubMed Central PMC7442822.
  7. MacKay, MJ, Hooker, AC, Afshinnekoo, E, Salit, M, Kelly, J, Feldstein, JV et al.. The COVID-19 XPRIZE and the need for scalable, fast, and widespread testing. Nat. Biotechnol. 2020;38 (9):1021-1024. doi: 10.1038/s41587-020-0655-4. PubMed PMID:32820257 .
  8. Ramlall, V, Thangaraj, PM, Meydan, C, Foox, J, Butler, D, Kim, J et al.. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Nat. Med. 2020; :. doi: 10.1038/s41591-020-1021-2. PubMed PMID:32747830 .
  9. Daudu, R, Parker, CW, Singh, NK, Wood, JM, Debieu, M, O'Hara, NB et al.. Draft Genome Sequences of Rhodotorula mucilaginosa Strains Isolated from the International Space Station. Microbiol Resour Announc. 2020;9 (31):. doi: 10.1128/MRA.00570-20. PubMed PMID:32732232 PubMed Central PMC7393961.
  10. Zook, JM, Hansen, NF, Olson, ND, Chapman, L, Mullikin, JC, Xiao, C et al.. Author Correction: A robust benchmark for detection of germline large deletions and insertions. Nat. Biotechnol. 2020; :. doi: 10.1038/s41587-020-0640-y. PubMed PMID:32699374 .
  11. Meydan, C, Afshinnekoo, E, Rickard, N, Daniels, G, Kunces, L, Hardy, T et al.. Improved gastrointestinal health for irritable bowel syndrome with metagenome-guided interventions. Precis Clin Med. 2020;3 (2):136-146. doi: 10.1093/pcmedi/pbaa013. PubMed PMID:32685241 PubMed Central PMC7327130.
  12. Taha, B, Winston, G, Tosi, U, Hartley, B, Hoffman, C, Dahmane, N et al.. Missing diversity in brain tumor trials. Neurooncol Adv. ;2 (1):vdaa059. doi: 10.1093/noajnl/vdaa059. PubMed PMID:32642711 PubMed Central PMC7316223.
  13. Sapoval, N, Mahmoud, M, Jochum, MD, Liu, Y, Leo Elworth, RA, Wang, Q et al.. Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission. bioRxiv. 2020; :. doi: 10.1101/2020.07.02.184481. PubMed PMID:32637955 PubMed Central PMC7337385.
  14. Van Metre, PC, Qi, S, Deacon, J, Dieter, C, Driscoll, JM, Fienen, M et al.. Prioritizing river basins for intensive monitoring and assessment by the US Geological Survey. Environ Monit Assess. 2020;192 (7):458. doi: 10.1007/s10661-020-08403-1. PubMed PMID:32594332 PubMed Central PMC7320945.
  15. Bijlani, S, Singh, NK, Mason, CE, Wang, CCC, Venkateswaran, K. Draft Genome Sequences of Tremellomycetes Strains Isolated from the International Space Station. Microbiol Resour Announc. 2020;9 (26):. doi: 10.1128/MRA.00504-20. PubMed PMID:32586865 PubMed Central PMC7317102.
  16. Yang, L, Zhang, X, MacKay, M, Foox, J, Hou, Q, Zheng, X et al.. Identification of Radioresponsive Genes in Esophageal Cancer from Longitudinal and Single Cell Exome Sequencing. Int. J. Radiat. Oncol. Biol. Phys. 2020; :. doi: 10.1016/j.ijrobp.2020.06.015. PubMed PMID:32561500 .
  17. Bijlani, S, Singh, NK, Mason, CE, Wang, CCC, Venkateswaran, K. Draft Genome Sequences of Sphingomonas Species Associated with the International Space Station. Microbiol Resour Announc. 2020;9 (25):. doi: 10.1128/MRA.00578-20. PubMed PMID:32554796 PubMed Central PMC7303416.
  18. Zook, JM, Hansen, NF, Olson, ND, Chapman, L, Mullikin, JC, Xiao, C et al.. A robust benchmark for detection of germline large deletions and insertions. Nat. Biotechnol. 2020; :. doi: 10.1038/s41587-020-0538-8. PubMed PMID:32541955 .
  19. Chang, E, Fu, C, Coon, SL, Alon, S, Bozinoski, M, Breymaier, M et al.. Resource: A multi-species multi-timepoint transcriptome database and webpage for the pineal gland and retina. J. Pineal Res. 2020;69 (3):e12673. doi: 10.1111/jpi.12673. PubMed PMID:32533862 .
  20. Chng, KR, Li, C, Bertrand, D, Ng, AHQ, Kwah, JS, Low, HM et al.. Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment. Nat. Med. 2020;26 (6):941-951. doi: 10.1038/s41591-020-0894-4. PubMed PMID:32514171 PubMed Central PMC7303012.
Search PubMed