Christopher Mason, Ph.D.

Associate Professor of Physiology and Biophysics

  • Director, WorldQuant Initiative for Quantitative Prediction and WorldQuant Foundation Research Scholar
  • Associate Professor of Computational Genomics in Computational Biomedicinein the Institute for Computational Biomedicine
  • Associate Professor of Neuroscience, Brain and Mind Institute (secondary appointment)

646-962-5643

1305 York Avenue, Room Y-13.15
New York, NY 10021


Techniques

Research Areas


Research Summary:

We utilize computational and experimental methodologies to identify and characterize the essential genetic elements that guide the function of the human genome, with a particular emphasis on the elements that orchestrate the development of the human brain. Our lab creates detailed cell-specific molecular maps of genetic, epigenetic, transcriptional, and translational activity, creating a draft of the molecular recipe for the creation of the brain. We also develop methods to detect, catalog and functionally annotate variants in the genetic pathways that control developmental processes and how they are perturbed to create disease. We aim to understand of the functional elements of the human genome well enough to enable, eventually, the ability to repair, re-engineer, or fortify these genetic networks within human cells.

Recent Publications:

  1. MacKay, M, Afshinnekoo, E, Rub, J, Hassan, C, Khunte, M, Baskaran, N et al.. The therapeutic landscape for cells engineered with chimeric antigen receptors. Nat. Biotechnol. 2020; :. doi: 10.1038/s41587-019-0329-2. PubMed PMID:31907405 .
  2. Mason, CE, McIntyre, ABR, Gokhale, NS, Cerchietti, L, Horner, SM. Methods and Tools for MeRIP-Seq and Nanopore Detection of m6A(m) Changes. J Biomol Tech. 2019;30 (Suppl):S56. . PubMed PMID:31897012 PubMed Central PMC6938088.
  3. Bezdan, D, Danko, D, Mason, CE. Distribution of Microbial Communities and Antimicrobial Resistances in Urban Environments and on the ISS Space Station. J Biomol Tech. 2019;30 (Suppl):S47. . PubMed PMID:31896984 PubMed Central PMC6938068.
  4. Iosim, S, MacKay, M, Westover, C, Mason, CE. Translating current biomedical therapies for long duration, deep space missions. Precis Clin Med. 2019;2 (4):259-269. doi: 10.1093/pcmedi/pbz022. PubMed PMID:31886035 PubMed Central PMC6927098.
  5. Gokhale, NS, McIntyre, ABR, Mattocks, MD, Holley, CL, Lazear, HM, Mason, CE et al.. Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection. Mol. Cell. 2019; :. doi: 10.1016/j.molcel.2019.11.007. PubMed PMID:31810760 .
  6. Walker, JA, Jordan, VE, Storer, JM, Steely, CJ, Gonzalez-Quiroga, P, Beckstrom, TO et al.. Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry. Mob DNA. 2019;10 :46. doi: 10.1186/s13100-019-0187-y. PubMed PMID:31788036 PubMed Central PMC6880559.
  7. Gochuico, BR, Ziegler, SG, Ten, NS, Balanda, NJ, Mason, CE, Zumbo, P et al.. A comprehensive, multidisciplinary, precision medicine approach to discover effective therapy for an undiagnosed, progressive, fibroinflammatory disease. Transl Res. 2020;215 :31-40. doi: 10.1016/j.trsl.2019.08.008. PubMed PMID:31520587 PubMed Central PMC6939610.
  8. Tan, L, Lacko, LA, Zhou, T, Tomoiaga, D, Hurtado, R, Zhang, T et al.. Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells. Nat Commun. 2019;10 (1):4155. doi: 10.1038/s41467-019-12063-2. PubMed PMID:31519912 PubMed Central PMC6744420.
  9. Liu, H, Begik, O, Lucas, MC, Ramirez, JM, Mason, CE, Wiener, D et al.. Accurate detection of m6A RNA modifications in native RNA sequences. Nat Commun. 2019;10 (1):4079. doi: 10.1038/s41467-019-11713-9. PubMed PMID:31501426 PubMed Central PMC6734003.
  10. Sims, CA, Holena, D, Kim, P, Pascual, J, Smith, B, Martin, N et al.. Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial. JAMA Surg. 2019; :. doi: 10.1001/jamasurg.2019.2884. PubMed PMID:31461138 PubMed Central PMC6714462.
  11. Ji, X, Tong, W, Ning, B, Mason, CE, Kreil, DP, Labaj, PP et al.. QuaPra: Efficient transcript assembly and quantification using quadratic programming with Apriori algorithm. Sci China Life Sci. 2019;62 (7):937-946. doi: 10.1007/s11427-018-9433-3. PubMed PMID:31124003 .
  12. Zhang, X, Alexander, N, Leonardi, I, Mason, C, Kirkman, LA, Deitsch, KW et al.. Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum. PLoS Biol. 2019;17 (5):e3000271. doi: 10.1371/journal.pbio.3000271. PubMed PMID:31083650 PubMed Central PMC6532940.
  13. Amann, RI, Baichoo, S, Blencowe, BJ, Bork, P, Borodovsky, M, Brooksbank, C et al.. Consent insufficient for data release-Response. Science. 2019;364 (6439):446. doi: 10.1126/science.aax7509. PubMed PMID:31048484 .
  14. Deng, Y, Zhu, Y, Wang, H, Khadka, VS, Hu, L, Ai, J et al.. Ratio-Based Method To Identify True Biomarkers by Normalizing Circulating ncRNA Sequencing and Quantitative PCR Data. Anal. Chem. 2019;91 (10):6746-6753. doi: 10.1021/acs.analchem.9b00821. PubMed PMID:31002238 PubMed Central PMC6884007.
  15. Garrett-Bakelman, FE, Darshi, M, Green, SJ, Gur, RC, Lin, L, Macias, BR et al.. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019;364 (6436):. doi: 10.1126/science.aau8650. PubMed PMID:30975860 .
  16. McIntyre, ABR, Ounit, R, Afshinnekoo, E, Prill, RJ, Hénaff, E, Alexander, N et al.. Correction to: Comprehensive benchmarking and ensemble approaches for metagenomic classifiers. Genome Biol. 2019;20 (1):72. doi: 10.1186/s13059-019-1687-2. PubMed PMID:30953547 PubMed Central PMC6450011.
  17. Krusche, P, Trigg, L, Boutros, PC, Mason, CE, De La Vega, FM, Moore, BL et al.. Author Correction: Best practices for benchmarking germline small-variant calls in human genomes. Nat. Biotechnol. 2019;37 (5):567. doi: 10.1038/s41587-019-0108-0. PubMed PMID:30899106 .
  18. Goldman, SL, Hassan, C, Khunte, M, Soldatenko, A, Jong, Y, Afshinnekoo, E et al.. Epigenetic Modifications in Acute Myeloid Leukemia: Prognosis, Treatment, and Heterogeneity. Front Genet. 2019;10 :133. doi: 10.3389/fgene.2019.00133. PubMed PMID:30881380 PubMed Central PMC6405641.
  19. Goldman, SL, MacKay, M, Afshinnekoo, E, Melnick, AM, Wu, S, Mason, CE et al.. The Impact of Heterogeneity on Single-Cell Sequencing. Front Genet. 2019;10 :8. doi: 10.3389/fgene.2019.00008. PubMed PMID:30881372 PubMed Central PMC6405636.
  20. Krusche, P, Trigg, L, Boutros, PC, Mason, CE, De La Vega, FM, Moore, BL et al.. Best practices for benchmarking germline small-variant calls in human genomes. Nat. Biotechnol. 2019;37 (5):555-560. doi: 10.1038/s41587-019-0054-x. PubMed PMID:30858580 PubMed Central PMC6699627.
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