Christopher Mason, Ph.D.

Professor of Physiology and Biophysics

  • Director, WorldQuant Initiative for Quantitative Prediction and WorldQuant Foundation Research Scholar
  • Professor of Computational Genomics in Computational Biomedicine in the Institute for Computational Biomedicine
  • Professor of Neuroscience in the Brain and Mind Institute (secondary appointment)

646-962-5643

1305 York Avenue, Room Y-13.15
New York, NY 10021


Techniques

Research Areas


Research Summary:

We utilize computational and experimental methodologies to identify and characterize the essential genetic elements that guide the function of the human genome, with a particular emphasis on the elements that orchestrate the development of the human brain. Our lab creates detailed cell-specific molecular maps of genetic, epigenetic, transcriptional, and translational activity, creating a draft of the molecular recipe for the creation of the brain. We also develop methods to detect, catalog and functionally annotate variants in the genetic pathways that control developmental processes and how they are perturbed to create disease. We aim to understand of the functional elements of the human genome well enough to enable, eventually, the ability to repair, re-engineer, or fortify these genetic networks within human cells.

Recent Publications:

  1. Chander, AM, Teixeira, MM, Singh, NK, Williams, MP, Simpson, AC, Damle, N et al.. Description and Genome Characterization of Three Novel Fungal Strains Isolated from Mars 2020 Mission-Associated Spacecraft Assembly Facility Surfaces-Recommendations for Two New Genera and One Species. J Fungi (Basel). 2022;9 (1):. doi: 10.3390/jof9010031. PubMed PMID:36675851 PubMed Central PMC9864340.
  2. Westover, C, Rahmatulloev, S, Danko, D, Afshin, EE, O'Hara, NB, Ounit, R et al.. Ozone Disinfection for Elimination of Bacteria and Degradation of SARS-CoV2 RNA for Medical Environments. Genes (Basel). 2022;14 (1):. doi: 10.3390/genes14010085. PubMed PMID:36672826 PubMed Central PMC9858956.
  3. Fortin, J, Chiang, MF, Meydan, C, Foox, J, Ramachandran, P, Leca, J et al.. Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells. Proc Natl Acad Sci U S A. 2023;120 (4):e2208176120. doi: 10.1073/pnas.2208176120. PubMed PMID:36652477 .
  4. Babler, KM, Sharkey, ME, Abelson, S, Amirali, A, Benitez, A, Cosculluela, GA et al.. Degradation rates influence the ability of composite samples to represent 24-hourly means of SARS-CoV-2 and other microbiological target measures in wastewater. Sci Total Environ. 2023;867 :161423. doi: 10.1016/j.scitotenv.2023.161423. PubMed PMID:36623667 PubMed Central PMC9817413.
  5. Gatt, C, Tierney, BT, Madrigal, P, Mason, CE, Beheshti, A, Telzerow, A et al.. The Maleth program: Malta's first space mission discoveries on the microbiome of diabetic foot ulcers. Heliyon. 2022;8 (12):e12075. doi: 10.1016/j.heliyon.2022.e12075. PubMed PMID:36544819 PubMed Central PMC9761711.
  6. Sierra, MA, Ryon, KA, Tierney, BT, Foox, J, Bhattacharya, C, Afshin, E et al.. Microbiome and metagenomic analysis of Lake Hillier Australia reveals pigment-rich polyextremophiles and wide-ranging metabolic adaptations. Environ Microbiome. 2022;17 (1):60. doi: 10.1186/s40793-022-00455-9. PubMed PMID:36544228 PubMed Central PMC9768965.
  7. Rasmika Dewi, DAP, Shiwa, Y, Ryon, K, Mason, CE, Matsumoto, T, Suzuki, H et al.. Urban Microbiomes in Narita, Chiba, Japan: Shotgun Metagenome Sequences of a Train Station. Microbiol Resour Announc. 2023;12 (1):e0109222. doi: 10.1128/mra.01092-22. PubMed PMID:36515525 PubMed Central PMC9872656.
  8. Park, J, Kim, J, Lewy, T, Rice, CM, Elemento, O, Rendeiro, AF et al.. Spatial omics technologies at multimodal and single cell/subcellular level. Genome Biol. 2022;23 (1):256. doi: 10.1186/s13059-022-02824-6. PubMed PMID:36514162 PubMed Central PMC9746133.
  9. Talsania, K, Shen, TW, Chen, X, Jaeger, E, Li, Z, Chen, Z et al.. Structural variant analysis of a cancer reference cell line sample using multiple sequencing technologies. Genome Biol. 2022;23 (1):255. doi: 10.1186/s13059-022-02816-6. PubMed PMID:36514120 PubMed Central PMC9746098.
  10. Tierney, BT, Singh, NK, Simpson, AC, Hujer, AM, Bonomo, RA, Mason, CE et al.. Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station. Microbiome. 2022;10 (1):210. doi: 10.1186/s40168-022-01358-0. PubMed PMID:36503581 PubMed Central PMC9743659.
  11. Salazar, C, Giménez, M, Riera, N, Parada, A, Puig, J, Galiana, A et al.. Human microbiota drives hospital-associated antimicrobial resistance dissemination in the urban environment and mirrors patient case rates. Microbiome. 2022;10 (1):208. doi: 10.1186/s40168-022-01407-8. PubMed PMID:36457116 PubMed Central PMC9715416.
  12. Overbey, EG, Das, S, Cope, H, Madrigal, P, Andrusivova, Z, Frapard, S et al.. Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight. Cell Rep Methods. 2022;2 (11):100325. doi: 10.1016/j.crmeth.2022.100325. PubMed PMID:36452864 PubMed Central PMC9701605.
  13. Zhan, Q, Babler, KM, Sharkey, ME, Amirali, A, Beaver, CC, Boone, MM et al.. Relationships between SARS-CoV-2 in Wastewater and COVID-19 Clinical Cases and Hospitalizations, with and without Normalization against Indicators of Human Waste. ACS ES T Water. 2022;2 (11):1992-2003. doi: 10.1021/acsestwater.2c00045. PubMed PMID:36398131 PubMed Central PMC9664448.
  14. Hay, JA, Kissler, SM, Fauver, JR, Mack, C, Tai, CG, Samant, RM et al.. Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: A retrospective cohort study. Elife. 2022;11 :. doi: 10.7554/eLife.81849. PubMed PMID:36383192 PubMed Central PMC9711520.
  15. Tierney, BT, Versalovic, J, Fasano, A, Petrosino, JF, Chumpitazi, BP, Mayer, EA et al.. Functional response to a microbial synbiotic in the gastrointestinal system of children: a randomized clinical trial. Pediatr Res. 2022; :. doi: 10.1038/s41390-022-02289-0. PubMed PMID:36319696 .
  16. Ryon, KA, Tierney, BT, Frolova, A, Kahles, A, Desnues, C, Ouzounis, C et al.. A history of the MetaSUB consortium: Tracking urban microbes around the globe. iScience. 2022;25 (11):104993. doi: 10.1016/j.isci.2022.104993. PubMed PMID:36299999 PubMed Central PMC9589169.
  17. Bhattacharya, C, Tierney, BT, Ryon, KA, Bhattacharyya, M, Hastings, JJA, Basu, S et al.. Supervised Machine Learning Enables Geospatial Microbial Provenance. Genes (Basel). 2022;13 (10):. doi: 10.3390/genes13101914. PubMed PMID:36292799 PubMed Central PMC9601318.
  18. Cope, H, Willis, CRG, MacKay, MJ, Rutter, LA, Toh, LS, Williams, PM et al.. Routine omics collection is a golden opportunity for European human research in space and analog environments. Patterns (N Y). 2022;3 (10):100550. doi: 10.1016/j.patter.2022.100550. PubMed PMID:36277820 PubMed Central PMC9583032.
  19. Venturutti, L, Rivas, MA, Pelzer, BW, Flümann, R, Hansen, J, Karagiannidis, I et al.. An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas. Cancer Discov. 2023;13 (1):216-243. doi: 10.1158/2159-8290.CD-22-0561. PubMed PMID:36264161 PubMed Central PMC9839622.
  20. Guevarra, RB, Hwang, J, Lee, H, Kim, HJ, Lee, Y, Danko, D et al.. Metagenomic characterization of bacterial community and antibiotic resistance genes found in the mass transit system in Seoul, South Korea. Ecotoxicol Environ Saf. 2022;246 :114176. doi: 10.1016/j.ecoenv.2022.114176. PubMed PMID:36257123 .
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