Christopher Mason, Ph.D.

Professor of Physiology and Biophysics

  • Director, WorldQuant Initiative for Quantitative Prediction and WorldQuant Foundation Research Scholar
  • Professor of Computational Genomics in Computational Biomedicine in the Institute for Computational Biomedicine
  • Professor of Neuroscience in the Brain and Mind Institute (secondary appointment)

646-962-5643

1305 York Avenue, Room Y-13.15
New York, NY 10021


Techniques

Research Areas


Research Summary:

We utilize computational and experimental methodologies to identify and characterize the essential genetic elements that guide the function of the human genome, with a particular emphasis on the elements that orchestrate the development of the human brain. Our lab creates detailed cell-specific molecular maps of genetic, epigenetic, transcriptional, and translational activity, creating a draft of the molecular recipe for the creation of the brain. We also develop methods to detect, catalog and functionally annotate variants in the genetic pathways that control developmental processes and how they are perturbed to create disease. We aim to understand of the functional elements of the human genome well enough to enable, eventually, the ability to repair, re-engineer, or fortify these genetic networks within human cells.

Recent Publications:

  1. Micklethwaite, KP, Gowrishankar, K, Gloss, BS, Li, Z, Street, JA, Moezzi, L et al.. Investigation of product derived lymphoma following infusion of piggyBac modified CD19 chimeric antigen receptor T-cells. Blood. 2021; :. doi: 10.1182/blood.2021010858. PubMed PMID:33974080 .
  2. Vogels, CBF, Breban, MI, Ott, IM, Alpert, T, Petrone, ME, Watkins, AE et al.. Multiplex qPCR discriminates variants of concern to enhance global surveillance of SARS-CoV-2. PLoS Biol. 2021;19 (5):e3001236. doi: 10.1371/journal.pbio.3001236. PubMed PMID:33961632 .
  3. McDonald, JT, Enguita, FJ, Taylor, D, Griffin, RJ, Priebe, W, Emmett, MR et al.. The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection. bioRxiv. 2021; :. doi: 10.1101/2021.04.23.441024. PubMed PMID:33948587 PubMed Central PMC8095194.
  4. Feola, M, Zamperone, A, Moskop, D, Chen, H, Casu, C, Lama, D et al.. Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation. Commun Biol. 2021;4 (1):517. doi: 10.1038/s42003-021-02046-9. PubMed PMID:33941818 PubMed Central PMC8093212.
  5. Simpson, AC, Urbaniak, C, Singh, NK, Wood, JM, Debieu, M, O'Hara, NB et al.. Draft Genome Sequences of Various Bacterial Phyla Isolated from the International Space Station. Microbiol Resour Announc. 2021;10 (17):. doi: 10.1128/MRA.00214-21. PubMed PMID:33927037 PubMed Central PMC8086211.
  6. Xiang, C, Frietze, KK, Bi, Y, Li, Y, Dal Pozzo, V, Pal, S et al.. RP58 represses transcriptional programs linked to non-neuronal cell identity and glioblastoma subtypes in developing neurons. Mol Cell Biol. 2021; :. doi: 10.1128/MCB.00526-20. PubMed PMID:33903225 .
  7. Alpert, T, Brito, AF, Lasek-Nesselquist, E, Rothman, J, Valesano, AL, MacKay, MJ et al.. Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States. Cell. 2021; :. doi: 10.1016/j.cell.2021.03.061. PubMed PMID:33891875 PubMed Central PMC8018830.
  8. Jones, W, Gong, B, Novoradovskaya, N, Li, D, Kusko, R, Richmond, TA et al.. A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency. Genome Biol. 2021;22 (1):111. doi: 10.1186/s13059-021-02316-z. PubMed PMID:33863366 PubMed Central PMC8051128.
  9. Gong, B, Li, D, Kusko, R, Novoradovskaya, N, Zhang, Y, Wang, S et al.. Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions. Genome Biol. 2021;22 (1):109. doi: 10.1186/s13059-021-02315-0. PubMed PMID:33863344 PubMed Central PMC8051090.
  10. Deveson, IW, Gong, B, Lai, K, LoCoco, JS, Richmond, TA, Schageman, J et al.. Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology. Nat Biotechnol. 2021; :. doi: 10.1038/s41587-021-00857-z. PubMed PMID:33846644 .
  11. Brune, Z, Kuschner, CE, Mootz, J, Davidson, KW, Pena, RCF, Ghanem, MH et al.. Effectiveness of SARS-CoV-2 Decontamination and Containment in a COVID-19 ICU. Int J Environ Res Public Health. 2021;18 (5):. doi: 10.3390/ijerph18052479. PubMed PMID:33802332 PubMed Central PMC7967612.
  12. Blachowicz, A, Singh, NK, Wood, JM, Debieu, M, O'Hara, NB, Mason, CE et al.. Draft Genome Sequences of Aspergillus and Penicillium Species Isolated from the International Space Station and Crew Resupply Vehicle Capsule. Microbiol Resour Announc. 2021;10 (13):. doi: 10.1128/MRA.01398-20. PubMed PMID:33795349 .
  13. Danko, DC, Sierra, MA, Benardini, JN, Guan, L, Wood, JM, Singh, N et al.. A comprehensive metagenomics framework to characterize organisms relevant for planetary protection. Microbiome. 2021;9 (1):82. doi: 10.1186/s40168-021-01020-1. PubMed PMID:33795001 PubMed Central PMC8016160.
  14. Bijlani, S, Singh, NK, Eedara, VVR, Podile, AR, Mason, CE, Wang, CCC et al.. Methylobacterium ajmalii sp. nov., Isolated From the International Space Station. Front Microbiol. 2021;12 :639396. doi: 10.3389/fmicb.2021.639396. PubMed PMID:33790880 PubMed Central PMC8005752.
  15. Walker, JM, Garcet, S, Aleman, JO, Mason, CE, Danko, D, Butler, D et al.. Author Correction: Obesity and ethnicity alter gene expression in skin. Sci Rep. 2021;11 (1):7524. doi: 10.1038/s41598-021-87276-x. PubMed PMID:33790371 PubMed Central PMC8012637.
  16. Rendeiro, AF, Ravichandran, H, Bram, Y, Chandar, V, Kim, J, Meydan, C et al.. The spatial landscape of lung pathology during COVID-19 progression. Nature. 2021; :. doi: 10.1038/s41586-021-03475-6. PubMed PMID:33780969 .
  17. Zhelyazkova, M, Yordanova, R, Mihaylov, I, Kirov, S, Tsonev, S, Danko, D et al.. Origin Sample Prediction and Spatial Modeling of Antimicrobial Resistance in Metagenomic Sequencing Data. Front Genet. 2021;12 :642991. doi: 10.3389/fgene.2021.642991. PubMed PMID:33763122 PubMed Central PMC7983949.
  18. Vogels, CBF, Breban, MI, Alpert, T, Petrone, ME, Watkins, AE, Ott, IM et al.. PCR assay to enhance global surveillance for SARS-CoV-2 variants of concern. medRxiv. 2021; :. doi: 10.1101/2021.01.28.21250486. PubMed PMID:33758901 PubMed Central PMC7987060.
  19. Park, J, Foox, J, Hether, T, Danko, D, Warren, S, Kim, Y et al.. Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps. bioRxiv. 2021; :. doi: 10.1101/2021.03.08.434433. PubMed PMID:33758858 PubMed Central PMC7987017.
  20. Butler, D, Mozsary, C, Meydan, C, Foox, J, Rosiene, J, Shaiber, A et al.. Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions. Nat Commun. 2021;12 (1):1660. doi: 10.1038/s41467-021-21361-7. PubMed PMID:33712587 PubMed Central PMC7954844.
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