Quantitative Understanding in Biology
Spring 2009

Home | Schedule and Lecture Notes | Prerequisites | Grading

Location: Weill Greenberg Center (1305 York Avenue); 13th Floor ICB Conf Room, Y.13.01

Module I: Statistics

26-Jan (12 pm): Welcome; Quantifying a Sample Distribution (lecture notes)
28-Jan (10 am): Probability Density Functions and the Normal Distribution (lecture notes)
2-Feb: (12 pm): SPECIAL TOPICS FACULTY LECTURE: Epigenetics and the HELP DNA Methylation Assay (Dr. Maria Figueroa) (slides)
4-Feb (10 am): Confidence Intervals and Contingency Tables (lecture notes)
9-Feb (12 pm): SPECIAL TOPICS FACULTY LECTURE: Behavioral Neuroscience (Dr. Glen Prusky)
11-Feb (10 am): P-Values and Formal Statistical Tests (lecture notes)
16-Feb (12 pm): President’s Day Holiday (reading: Cummings 2007; PMID: 17420288)
18-Feb (10 am): Large Datasets, Data Mining, and Multiple Hypothesis Testing (and some other stuff) (lecture notes)

Module II: Model Parameter Estimation

23-Feb (12 pm): Correlation and Linear Regression (lecture notes)
25-Feb (10 am): Canceled
2-Mar (12 pm): Fitting Model Parameters to Data -- part I (lecture notes) / Statistics Computer Laboratory (Exercise Files)
4-Mar (10 am): SPECIAL TOPICS FACULTY LECTURE: Machine Learning Methods in Biology (Dr. Christina Leslie) (slides; Bild, et. al. 2007; PMID: 16273092)
9-Mar (12 pm): Fitting Model Parameters to Data -- part II (see notes for 2Mar) / Quantitative Comparison of Models -- part I (lecture notes)
11-Mar (10 am): SPECIAL TOPICS FACULTY LECTURE: Gene Expression Networks (Dr. Olivier Elemento) (slides)
16-Mar (12 pm): SPECIAL TOPICS FACULTY LECTURE: SNPs and Copy Number Variation (Dr. Francesca Demichelis) (slides)
18-Mar (10 am): Quantitative Comparison of Models -- part II (see notes for Mar 9)

Module III: Linear Difference Equations and Linear Algebra

23-Mar (12 pm): Introduction to Linear Difference Equations / Linear Algebra Review (lecture notes)
25-Mar (10 am): Analysis of Systems of Linear Difference Equations -- Part I
30-Mar (12 pm): SPECIAL TOPICS FACULTY LECTURE: Medical Image Analysis (Dr. Ashish Raj) (slides)
1-Apr (10 am): Analysis of Systems of Linear Difference Equations -- Part II / Model Parameter Estimation Computer Laboratory (Problem Set)
6-Apr: (Spring Break)
8-Apr: (Spring Break)
13-Apr (12 pm): SPECIAL TOPICS FACULTY LECTURE: Applications of Markov Chains to Ion Channels (Dr. Colleen Clancy)
15-Apr (10 am): Midterm Exam (the exam will be held in LC-504, the Physiology conference room, 1300 York Ave, 5th floor)

Module IV: Dynamical Systems and Ordinary Differential Equations

20-Apr (12 pm): Representing Time Dependent Phenomena with ODEs; Numerical Evaluation of ODE Models (lecture notes)
22-Apr (10 am): SPECIAL TOPICS FACULTY LECTURE: Modeling Cardiac Electrodynamics (Dr. Trine Krogh-Madsen)
27-Apr (12 pm): Analysis of Sets of Linear ODEs; Non-linear ODEs
29-Apr (10 am): Difference and Differential Equations Computer Laboratory (problem set)
4-May (12 pm): SPECIAL TOPICS FACULTY LECTURE: Voltage Gated Channels (Dr. Colleen Clancy)
6-May (10 am): SPECIAL TOPICS FACULTY LECTURE: Introduction to Control Theory (Dr. Emre Aksay)

Conclusion

11-May (12 pm): SPECIAL TOPICS FACULTY LECTURE: Modeling the Evolution of Cancer (Dr. Franziska Michor)
13-May (10 am): SPECIAL TOPICS FACULTY LECTURE: Rule Based Modeling of the Immune System (Dr. Grégoire Altan-Bonnet)
18-May (12 pm): Fourier and Principal Component Analysis (lecture notes)
20-May (10 am): SPECIAL TOPICS FACULTY LECTURE: Network Modeling (Dr. Emre Askay)
25-May: (Memorial Day)
27-May (10 am): Students’ Final Project Presentations (Keigo Kawaji and Tian Liu)
1-Jun (12 pm): Students’ Final Project Presentations (Katie Fenz, Nurunisa Neyzi)
3-Jun (10 am): Students’ Final Project Presentations (Michael Wasserman, Sayan Mondal, Xuan Zhu, Jonathan Moreno)
8-Jun (12 pm): Students’ Final Project Presentations
10-Jun (10 am): Final Exam (the exam will be held in LC-504, the Physiology conference room, 1300 York Ave, 5th floor)