Physiology, the oldest and most fundamental of the basic medical sciences, is the science of the function of living organisms, including humans. In the Department of Physiology and Biophysics, our techniques are modern and are constantly evolving, our questions are immediate, but our basic quest remains constant. As Physiologists we ask how biological processes - from molecules to organisms - perform their functions. As Biophysicists we ask how these processes - and life itself - build upon the laws of mathematics, physics, and chemistry.

Recent publications by members of the Department of Physiology and Biophysics:
  1. Razavi AM, Khelashvili G, Weinstein H. How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties BMC BiolMar 2018 PMID: 29540172
  2. Terry DS, Kolster RA, Quick M, LeVine MV, Khelashvili G, Zhou Z, Weinstein H, Javitch JA, Blanchard SC. A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport Nat CommunJan 2018 PMID: 29335402
  3. Morra G, Razavi AM, Pandey K, Weinstein H, Menon AK, Khelashvili G. Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin StructureDec 2017 PMID: 29290486
  4. Pandey K, Ploier B, Goren MA, Levitz J, Khelashvili G, Menon A. An engineered opsin monomer scrambles phospholipids Sci Rep.Nov 2017 PMID: 29196630
  5. Doktorova M, Heberle FA, Kingston RL, Khelashvili G, Cuendet MA, Wen Y, Katsaras J, Feigenson GW, Vogt VM, Dick RA. Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties Biophys JNov 2017 PMID: 29117524
  6. Sylvester SJG, Lee MM, Ramirez AD, Lim S, Goldman MS, Aksay ERF. Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior Sci Rep.Nov 2017 PMID: 29176570
  7. LeVine MV, Cuendet MA, Razavi AM, Khelashvili G, Weinstein H. Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter Biophys JNov 2017 PMID: 29153319
  8. Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen S, Gardner KH, Rosenbaum DM. Ligand modulation of sidechain dynamics in a wild-type human GPCR ElifeOct 2017 PMID: 28984574
  9. Vishwanathan A, Daie K, Ramirez AD, Lichtman JW, Aksay ERF, Seung HS. Electron Microscopic Reconstruction of Functionally Identified Cells in a Neural Integrator Curr Biol.Jul 2017 PMID: 28712570
  10. Alice Verchère, Wei-Lin Ou, Birgit Ploier, Takefumi Morizumi, Michael A. Goren, Peter Bütikofer, Oliver P. Ernst, George Khelashvili & Anant K. Menon. Light-independent phospholipid scramblase activity of bacteriorhodopsin from Halobacterium salinarum Sci Rep.Jul 2017 PMID: 28842688
  11. Weinstein AM. A mathematical model of the rat kidney: K+-induced natriuresis. Am J Physiol Renal PhysiolJun 2017 PMID: 28179254
  12. Doktorova M, Harries D, Khelashvili G. Determination of bending rigidity and tilt modulus of lipid membranes from real-space fluctuation analysis of molecular dynamics simulations Phys. Chem. Chem. Phys.Jun 2017 PMID: 28627570
  13. Razavi AM, Khelashvili G, Weinstein H. A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter Nat Sci RepJan 2017 PMID: 28059145
  14. Sahai MA, Davidson C, Khelashvili G, Barrese V, Dutta N, Weinstein H, Opacka-Juffry J. Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances – The case of the benzofuran 5-MAPB J pnpbpNov 2016 PMID: 27890676
  15. Cuendet MA, Weinstein H, LeVine MV. The Allostery Landscape: Quantifying Thermodynamic Couplings in Biomolecular Systems JCTCNov 2016 PMID: 27766843
  16. Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H. Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290 J Biol ChemSep 2016 PMID: 27474737
  17. Veerappan A, Thompson M, Savage AR, Silverman ML, Chan WS, Sung B, Summers B, Montelione KC, Benedict P, Groh B, Vicencio AG, Peinado H, Worgall S, Silver RB. Mast cells and exosomes in hyperoxia-induced neonatal lung disease. AJPJun 2016 PMID: 27130530
  18. Zhao Y, Fay F, Hak S, Manuel Perez-Aguilar J, Sanchez-Gaytan BL, Goode B, Duivenvoorden R, de Lange Davies C, Bjørkøy A, Weinstein H, Fayad ZA, Pérez-Medina C, Mulder WJ. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nat CommunApr 2016 PMID: 27071376
  19. Johner N, Harries D, Khelashvili G. Implementation of a methodology for determining elastic properties of lipid assemblies from molecular dynamics simulations BMC BioinfApr 2016 PMID: 27071656
  20. LeVine MV, Cuendet MA, Khelashvili G, Weinstein H. Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters Chem RevFeb 2016 PMID: 26892914
  21. LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H. Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles BiochemFeb 2016 PMID: 26811944
  22. Arango-Lievano M, Sensoy O, Borie A, Corbani M, Guillon G, Sokoloff P, Weinstein H, Jeanneteau F. A GIPC1-Palmitate Switch Modulates Dopamine Drd3 Receptor Trafficking and Signaling Mol Cell BiolJan 2016 PMID: 26787837
  23. Stolzenberg S, Michino M, LeVine MV, Weinstein H, Shi L. Computational approaches to detect allosteric pathways in transmembrane molecular machines Biochim Biophys Acta.Jan 2016 PMID: 26806157
  24. Khelashvili G, Stanley N, Sahai MA, Medina J, LeVine MV, Shi L, De Fabritiis G, Weinstein H. Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2‐Regulated Dynamics of the N‐Terminus ACS Chem NeurosciNov 2015 PMID: 26255829
  25. Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U. Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter J Biol ChemOct 2015 PMID: 26363074
  26. Khelashvili G, Weinstein H. Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops Biochim Biophys Acta.Sep 2015 PMID: 25847498
  27. Karlsen ML, Thorsen TS, Johner N, Ammendrup-Johnsen I, Erlendsson S, Tian X, Simonsen JB, Høiberg-Nielsen R, Christensen NM, Khelashvili G, Streicher W, Teilum K, Vestergaard B, Weinstein H, Gether U, Arleth L, Madsen KL. Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering StructureJul 2015 PMID: 26073603
  28. Weinstein AM. A mathematical model of rat proximal tubule and loop of Henle Am J Physiol Renal PhysiolMay 2015 PMID: 25694479
  29. Weinstein AM. A mathematical model of the rat nephron: glucose transport. Am J Physiol Renal PhysiolMay 2015 PMID: 25694480
  30. Lee MM, Arrenberg AB, Aksay ER. A structural and genotypic scaffold underlying temporal integration J NeurosciMay 2015 PMID: 25995475
  31. LeVine MV, Weinstein H. AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems EntropyMay 2015 PMID: 26594108
  32. Khelashvili G, Doktorova M, Sahai MA, Johner N, Shi L, Weinstein H. Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2-containing membranes ProteinsMay 2015 PMID: 25739722
  33. Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L. Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters J Biol ChemMay 2015 PMID: 25869126
  34. Sensoy O, Weinstein H. A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1–PDZ-domain Biochim Biophys Acta.Apr 2015 PMID: 25592838
  35. Kulig W, Olżyńska A, Jurkiewicz P, Kantola AM, Komulainen S, Manna M, Pourmousa M, Vazdar M, Cwiklik L, Rog T, Khelashvili G, Harries D, Telkki VV, Hof M, Vattulainen I, Jungwirth P. Cholesterol under oxidative stress—How lipid membranes sense oxidation as cholesterol is being replaced by oxysterols Free Radic Biol Med. Mar 2015 PMID: 25795515
  36. Daie K, Goldman MS, Aksay ERF. Spatial patterns of persistent neural activity vary with the behavioral context of short-term memory NeuronFeb 2015 PMID: 25661184
  37. Akyuz N, Georgieva ER, Zhou Z, Stolzenberg S, Cuendet MA, Khelashvili G, Altman RB, Terry DS, Freed JH, Weinstein H, Boudker O, Blanchard SC. Transport domain unlocking sets the uptake rate of an aspartate transporter NatureFeb 2015 PMID: 25652997