Physiology, the oldest and most fundamental of the basic medical sciences, is the science of the function of living organisms, including humans. In the Department of Physiology and Biophysics, our techniques are modern and are constantly evolving, our questions are immediate, but our basic quest remains constant. As Physiologists we ask how biological processes - from molecules to organisms - perform their functions. As Biophysicists we ask how these processes - and life itself - build upon the laws of mathematics, physics, and chemistry.

Recent publications by members of the Department of Physiology and Biophysics:
  1. Stolzenberg S, Khelashvili G, Weinstein H. Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh J Phys Chem B, May 2012 PMID: 22494242
  2. Demichelis F, Setlur SR, Banerjee S, Chakravarty D, Chen JY, Chen CX, Huang J, Beltran H, Oldridge DA, Kitabayashi N, Stenzel B, Schaefer G, Horninger W, Bektic J, Chinnaiyan AM, Goldenberg S, Siddiqui J, Regan MM, Kearney M, Soong TD, Rickman DS, Elemento O, Wei JT, Scherr DS, Sanda MA, Bartsch G, Lee C, Klocker H, Rubin MA. Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk PNAS, Apr 2012 PMID: 22496589
  3. Shan J, Khelashvili G, Mondal S, Mehler EL, Weinstein H. Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT(2A) Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties PLoS Comp Biol, Apr 2012 PMID: 22532793
  4. Gravotta D, Carvajal-Gonzalez JM, Mattera R, Deborde S, Banfelder JR, Bonifacino JS, Rodriguez-Boulan E. The Clathrin Adaptor AP-1A Mediates Basolateral Polarity Dev Cell, Apr 2012 PMID: 22516199
  5. Freeman K, Staehle MM, Gumus ZH, Vadigepalli R, Gonye GE, Nichols CN, Ogunnaike BA, Hoek JB, Schwaber JS. Rapid Temporal Changes in the Expression of a Set of Neuromodulatory Genes During Alcohol Withdrawal in the Dorsal Vagal Complex: Molecular Evidence of Homeostatic Disturbance Alcohol Clin Exp Res, In press
  6. Jahid S, Sun J, Edwards R, Dizon D, Panarelli N, Milsom JW, Sikandar SS, Gumus ZH, Lipkin SM. miR-23a Promotes the Transition from Indolent to Invasive Colorectal Cancer Cancer Disc, Mar 2012
  7. McCoy JG, Nimigean CM. Structural correlates of selectivity and inactivation in potassium channels Biochim Biophys Acta., Feb 2012 PMID: 21958666
  8. Quick M, Shi L, Zehnpfennig B, Weinstein H, Javitch JA. Experimental conditions can obscure the second high-affinity site in LeuT Nat Struct Mol Biol, Jan 2012 PMID: 22245968
  9. Veerappan A, Reid AC, O'Connor N, Mora R, Brazin JA, Estephan R, Kameue T, Chen J, Felsen D, Seshan SV, Poppas DP, Maack T, Silver RB. Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model Am J Physiol Renal Physiol, Jan 2012 PMID: 21957176
  10. Frindt G, Palmer LG. Regulation of epithelial Na+ channels by adrenal steroids: mineralocorticoid and glucocorticoid effects Am J Physiol Renal Physiol, Jan 2012 PMID: 22012806
  11. Suresh A, Vannan M, Kumaran D, Gümüs ZH, Sivadas P, Murugaian EE, Kekatpure V, Iyer S, Thangaraj K, Kuriakose MA. Resistance/response molecular signature for oral tongue squamous cell carcinoma Dis Markers, Jan 2012 PMID: 22297602
  12. Wang L, Altman RB, Blanchard SC. Insights into the molecular determinants of EF-G catalyzed translocation RNA, Dec 2011 PMID: 22033333
  13. Edvinsson JM, Shah AJ, Palmer LG. Potassium-dependent activation of Kir4.2 K+ channels J Physiol, Dec 2011 PMID: 22025665
  14. Weinstein H, Scarlata S. The correlation between multidomain enzymes and multiple activation mechanisms--the case of phospholipase Cβ and its membrane interactions Biochim Biophys Acta., Dec 2011 PMID: 21906583
  15. Altman RB, Terry DS, Zhou Z, Zheng Q, Geggier P, Kolster RA, Zhao Y, Javitch JA, Warren JD, Blanchard SC. Cyanine fluorophore derivatives with enhanced photostability Nat Methods, Nov 2011 PMID: 22081126
  16. Weinstein AM. Potassium Excretion During Antinatriuresis: Perspective from a Distal Nephron Model Am J Physiol Renal Physiol, Nov 2011 PMID: 22114205
  17. Mondal S, Khelashvili G, Shan J, Andersen OS, Weinstein H. Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors Biophys J, Nov 2011 PMID: 22067146
  18. Snyder M, Huang XY, Zhang JJ. Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration J Biol Chem, Nov 2011 PMID: 21937440
  19. Reid AC, Brazin JA, Morrey C, Silver RB, Levi R. Targeting cardiac mast cells: pharmacological modulation of the local renin-angiotensin system Curr Pharm Des, Nov 2011 PMID: 22103845
  20. Ingólfsson HI, Koeppe RE 2nd, Andersen OS. Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties FEBS Lett, Oct 2011 PMID: 21896274
  21. Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM. Structure and dynamics of the mammalian ribosomal pretranslocation complex Mol Cell, Oct 2011 PMID: 22017870
  22. Han DS, Golebiewska U, Stolzenberg S, Scarlata SF, Weinstein H. A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits Mol Pharmacol, Sep 2011 PMID: 21693623
  23. Capetillo-Zarate E, Gracia L, Yu F, Banfelder JR, Lin MT, Tampellini D, Gouras GK. High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils Am J Pathol, Sep 2011 PMID: 21925470
  24. Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY. Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization J Biol Chem, Sep 2011 PMID: 21771786
  25. Ingólfsson HI, Andersen OS. Alcohol's effects on lipid bilayer properties Biophys J, Aug 2011 PMID: 21843475
  26. Greisen P Jr, Lum K, Ashrafuzzaman M, Greathouse DV, Andersen OS, Lundbæk JA. Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling PNAS, Aug 2011 PMID: 21768343
  27. Yao Q, Li H, Liu BQ, Huang XY, Guo L. SUMOylation-regulated protein phosphorylation, evidence from quantitative phosphoproteomics analyses J Biol Chem, Aug 2011 PMID: 21685386
  28. Miri A, Daie K, Arrenberg AB, Baier H, Aksay E, Tank DW. Spatial gradients and multidimensional dynamics in a neural integrator circuit Nat Neurosci, Aug 2011 PMID: 21857656
  29. Rusinova R, Herold KF, Sanford RL, Greathouse DV, Hemmings HC Jr, Andersen OS. Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery J Gen Physiol, Aug 2011 PMID: 21788612
  30. Frindt G, Houde V, Palmer LG. Conservation of Na+ vs. K+ by the rat cortical collecting duct Am J Physiol Renal Physiol, Jul 2011 PMID: 21454253
  31. Aaker GD, Gracia L, Myung JS, Borcherding V, Banfelder JR, D'Amico DJ, Kiss S. Volumetric three-dimensional reconstruction and segmentation of spectral-domain OCT Ophthalmic Surg Lasers Imaging, Jul 2011 PMID: 21790107
  32. Haller A, Rieder U, Aigner M, Blanchard SC, Micura R. Conformational capture of the SAM-II riboswitch Nat Chem Biol, Jun 2011 PMID: 21532598
  33. Ingólfsson HI, Li Y, Vostrikov VV, Gu H, Hinton JF, Koeppe RE 2nd, Roux B, Andersen OS. Gramicidin A backbone and side chain dynamics evaluated by molecular dynamics simulations and nuclear magnetic resonance experiments. I: molecular dynamics simulations J Phys Chem B, Jun 2011 PMID: 21574563
  34. Vostrikov VV, Gu H, Ingólfsson HI, Hinton JF, Andersen OS, Roux B, Koeppe RE 2nd. Gramicidin A backbone and side chain dynamics evaluated by molecular dynamics simulations and nuclear magnetic resonance experiments. II: nuclear magnetic resonance experiments J Phys Chem B, Jun 2011 PMID: 21574558
  35. Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homolog Nature, Jun 2011 PMID: 21516104
  36. Gu H, Lum K, Kim JH, Greathouse DV, Andersen OS, Koeppe RE 2nd. The membrane interface dictates different anchor roles for "inner pair" and "outer pair" tryptophan indole rings in gramicidin A channels Biochem, Jun 2011 PMID: 21539360
  37. Aaker GD, Gracia L, Myung JS, Borcherding V, Banfelder JR, D'Amico DJ, Kiss S. Three-dimensional reconstruction and analysis of vitreomacular traction: quantification of cyst volume and vitreoretinal interface area Arch Ophthalmol, Jun 2011 PMID: 21670354
  38. Edvinsson JM, Shah AJ, Palmer LG. Kir4.1 K+ channels are regulated by external cations Channels, May 2011 PMID: 21532341
  39. Nimigean CM, Allen TW. Origins of ion selectivity in potassium channels from the perspective of channel block J Gen Physiol, May 2011 PMID: 21518829
  40. Andersen OS. Perspectives on: Ion selectivity J Gen Physiol, May 2011 PMID: 21518827
  41. Dunkle JA, Wang L, Feldman MB, Pulk A, Chen VB, Kapral GJ, Noeske J, Richardson JS, Blanchard SC, Cate JH. Structures of the bacterial ribosome in classical and hybrid states of tRNA binding Science, May 2011 PMID: 21596992
  42. Cheng WW, McCoy JG, Thompson AN, Nichols CG, Nimigean CM. Mechanism for selectivity-inactivation coupling in KcsA potassium channels PNAS, Mar 2011 PMID: 21402935
  43. Sackin H, Nanazashvili M, Li H, Palmer LG, Yang L. Modulation of Kir1.1 inactivation by extracellular Ca and Mg Biophys J, Mar 2011 PMID: 21354393
  44. Stember JN, Andersen O. A one-dimensional continuum elastic model for membrane-embedded gramicidin dimer dissociation PLoS One, Feb 2011 PMID: 21326605
  45. Maretzky T, Zhou W, Huang XY, Blobel CP. A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17 Oncogene, Feb 2011 PMID: 20871631
  46. Cohen FS, Andersen OS. Cells on the MEND: exploring the role of lipidic forces in membrane trafficking J Gen Physiol, Feb 2011 PMID: 21242298
  47. Banerjee S, Nimigean CM. Non-vesicular transfer of membrane proteins from nanoparticles to lipid bilayers J Gen Physiol, Feb 2011 PMID: 21282400
  48. Miri A, Daie K, Burdine RD, Aksay E, Tank DW. Regression-based identification of behavior-encoding neurons during large-scale optical imaging of neural activity at cellular resolution J Neurophysiol, Feb 2011 PMID: 21084686
  49. Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJ, Li Y, Meyer S, Erpelinck-Verschueren C, Greally J, Löwenberg B, Melnick A, Delwel R. Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1 Blood, Jan 2011 PMID: 20855866
  50. He Y, Liwo A, Weinstein H, Scheraga HA. PDZ Binding to the BAR Domain of PICK1 is Elucidated by Coarse-grained Molecular Dynamics J Mol Biol, Jan 2011 PMID: 21050858
  51. Yu F, Sun L, Courjaret R, Machaca K. Role of the STIM1 C-terminal domain in STIM1 clustering J Biol Chem, Jan 2011 PMID: 21220431
  52. Safdieh JE, Lin AL, Aizer J, Marzuk PM, Grafstein B, Storey-Johnson C, Kang Y. Standardized patient outcomes trial (SPOT) in neurology Med Educ Online, Jan 2011 PMID: 21249174
  53. Snyder M, Huang XY, Zhang JJ. Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene FEBS Lett, Jan 2011 PMID: 21094641
  54. Grafstein B. Subverting the hegemony of the synapse: complicity of neurons, astrocytes, and vasculature in spreading depression and pathology of the cerebral cortex Brain Res Rev, Jan 2011 PMID: 20888859
  55. Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. The binding sites for benztropines and dopamine in the dopamine transporter overlap Neuropharm, Jan 2011 PMID: 20816875
  56. Shan J, Javitch JA, Shi L, Weinstein H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter PLoS One, Jan 2011 PMID: 21298009
  57. Shi L, Weinstein H. Conformational Rearrangements to the Intracellular Open States of the LeuT and ApcT Transporters Are Modulated by Common Mechanisms Biophys J, Dec 2010 PMID: 21156121
  58. Munro JB, Wasserman MR, Altman RB, Wang L, Blanchard SC. Correlated conformational events in EF-G and the ribosome regulate translocation Nat Struct Mol Biol, Dec 2010 PMID: 21057527
  59. Yang L, Frindt G, Palmer LG. Magnesium modulates ROMK channel-mediated potassium secretion J Am Soc Nephrol, Dec 2010 PMID: 21030597
  60. Shan J, Weinstein H, Mehler EL. Probing the structural determinants for the function of intracellular loop 2 in structurally cognate g-protein-coupled receptors Biochem, Dec 2010 PMID: 21062002
  61. Duan Y, Weinstein AM, Weinbaum S, Wang T. Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells PNAS, Dec 2010 PMID: 21106755
  62. Machaca K. Ca(2+) signaling, genes and the cell cycle Cell Calcium, Nov 2010 PMID: 21084120
  63. Yu F, Sun L, Machaca K. Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis JCB, Nov 2010 PMID: 21041445
  64. Li Y, Andersen OS, Roux B. Energetics of double-ion occupancy in the gramicidin A channel J Phys Chem B, Nov 2010 PMID: 20939567
  65. Brandl K, Sun L, Neppl C, Siggs OM, Le Gall SM, Tomisato W, Li X, Du X, Maennel DN, Blobel CP, Beutler B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands PNAS, Nov 2010 PMID: 21041656
  66. Frindt G, Palmer LG. Effects of dietary K on cell-surface expression of renal ion channels and transporters Am J Physiol Renal Physiol, Oct 2010 PMID: 20702602
  67. Morrey C, Brazin J, Seyedi N, Corti F, Silver RB, Levi R. Interaction between sensory C-fibers and cardiac mast cells in ischemia/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction J Pharmacol Exp Ther, Oct 2010 PMID: 20668055
  68. Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1 Org Biomol Chem, Oct 2010 PMID: 20668766
  69. Khelashvili G, Mondal S, Andersen OS, Weinstein H. Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors J Phys Chem B, Sep 2010 PMID: 20804205
  70. Yu H, Mazzanti CL, Whitfield TW, Koeppe RE, Andersen OS, Roux B. A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide J Am Chem Soc, Aug 2010 PMID: 20681718
  71. Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells Circulation, Aug 2010 PMID: 20697027
  72. Lundbaek JA, Koeppe RE 2nd, Andersen OS. Amphiphile regulation of ion channel function by changes in the bilayer spring constant PNAS, Aug 2010 PMID: 20713738
  73. Accardi A, Picollo A. CLC channels and transporters: proteins with borderline personalities Biochim Biophys Acta., Aug 2010 PMID: 20188062
  74. Daily AE, Kim JH, Greathouse DV, Andersen OS, Koeppe RE 2nd. Polar groups in membrane channels: consequences of replacing alanines with serines in membrane-spanning gramicidin channels Biochem, Aug 2010 PMID: 20695525
  75. Schreiner R, Frindt G, Diaz F, Carvajal-Gonzalez JM, Perez Bay AE, Palmer LG, Marshansky V, Brown D, Philp NJ, Rodriguez-Boulan E. The absence of a clathrin adapter confers unique polarity essential to proximal tubule function Kidney Intl, Aug 2010 PMID: 20531453
  76. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base Bioinf, Jul 2010 PMID: 20501551
  77. Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS. Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters Nat Struct Mol Biol, Jul 2010 PMID: 20562855
  78. Arredouani A, Yu F, Sun L, Machaca K. Regulation of store-operated Ca2+ entry during the cell cycle J Cell Sci, Jul 2010 PMID: 20554894
  79. Snyder M, Huang XY, Zhang JJ. Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells J Biol Chem, Jul 2010 PMID: 20522556
  80. Pandarinath C, Victor JD, Nirenberg S. Symmetry breakdown in the ON and OFF pathways of the retina at night: functional implications J Neurosci, Jul 2010 PMID: 20668185
  81. Whitford PC, Geggier P, Altman RB, Blanchard SC, Onuchic JN, Sanbonmatsu KY. Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways RNA, Jun 2010 PMID: 20427512
  82. B Grafstein. Axonal Transport: The Intracellular Traffic of the Neuron Comprehensive Physiology, Jun 2010
  83. Geggier P, Dave R, Feldman MB, Terry DS, Altman RB, Munro JB, Blanchard SC. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome J Mol Biol, Jun 2010 PMID: 20434456
  84. Nirenberg S, Bomash I, Pillow JW, Victor JD. Heterogeneous response dynamics in retinal ganglion cells: the interplay of predictive coding and adaptation J Neurophysiol, Jun 2010 PMID: 20357061
  85. Blanchard SC, Cooperman BS, Wilson DN. Probing translation with small-molecule inhibitors Chem Biol, Jun 2010 PMID: 20609413
  86. Picollo A, Malvezzi M, Accardi A. Proton block of the CLC-5 Cl-/H+ exchanger JGP, Jun 2010 PMID: 20513761
  87. Sackin H, Nanazashvili M, Li H, Palmer LG, Walters DE. A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity Channels, May 2010 PMID: 20458182
  88. Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. Single-molecule dynamics of gating in a neurotransmitter transporter homologue Nature, May 2010 PMID: 20463731
  89. Brass LF, Akabas MH, Burnley LD, Engman DM, Wiley CA, Andersen OS. Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs Acad Med, Apr 2010 PMID: 20186033
  90. Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis Nature, Apr 2010 PMID: 20393565
  91. Tanabe M, Nimigean CM, Iverson TM. Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB PNAS, Apr 2010 PMID: 20351243
  92. Pandarinath C, Bomash I, Victor JD, Prusky GT, Tschetter WW, Nirenberg S. A novel mechanism for switching a neural system from one state to another Front Comput Neurosci, Mar 2010 PMID: 20407612
  93. Boyle JO, Gümüs ZH, Kacker A, Choksi VL, Bocker JM, Zhou XK, Yantiss RK, Hughes DB, Du B, Judson BL, Subbaramaiah K, Dannenberg AJ. Effects of Cigarette Smoke on the Human Oral Mucosal Transcriptome Cancer Prev Res, Mar 2010 PMID: 20179299
  94. Ge X, Roux B. Calculation of the standard binding free energy of sparsomycin to the ribosomal peptidyl-transferase P-site using molecular dynamics simulations with restraining potentials J Mol Recog, Feb 2010 PMID: 20151411
  95. Zeynep H. Gümüş, Fernando Siso-Nadal, Ada Gjyrezi, Paul McDonagh, Iya Khalil, Paraskevi Giannakakou and Harel Weinstein. Quantification and analysis of combination drug synergy in high-throughput transcriptome studies IEEE Conf. Bioinf. Bioeng., Feb 2010
  96. Ingólfsson HI, Andersen OS. Screening for Small Molecules’ Bilayer- Modifying Potential Using a Gramicidin-Based Fluorescence Assay Assay Drug Devel Tech, Feb 2010 PMID: 20233091
  97. Guo D, Zhang JJ, Huang XY. A new Rac/PAK/GC/cGMP signaling pathway Mol Cell Biol, Jan 2010 PMID: 19937092
  98. Feldman MB, Terry DS, Altman RB, Blanchard SC. Aminoglycoside activity observed on single pre-translocation ribosome complexes Nat Chem Biol, Jan 2010 PMID: 19946275
  99. Figueroa ME, Lugthart S, Li Y, Erpelinck-Verschueren C, Deng X, Christos PJ, Schifano E, Booth J, van Putten W, Skrabanek L, Campagne F, Mazumdar M, Greally JM, Valk PJ, Löwenberg B, Delwel R, Melnick A. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia Cancer Cell, Jan 2010 PMID: 20060365
  100. Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, Rønn LC, Gether U. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD PNAS, Jan 2010 PMID: 20018661
  101. Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, Blobel CP. Pathological Neovascularization Is Reduced by Inactivation of ADAM17 in Endothelial Cells but Not in Pericytes Circ Res, Jan 2010 PMID: 20110534
  102. Munro JB, Altman RB, Tung CS, Cate JH, Sanbonmatsu KY, Blanchard SC. Spontaneous formation of the unlocked state of the ribosome is a multistep process PNAS, Jan 2010 PMID: 20018653
  103. Munro JB, Altman RB, Tung CS, Sanbonmatsu KY, Blanchard SC. A fast dynamic mode of the EF-G-bound ribosome EMBO J, Dec 2009 PMID: 20033061
  104. Picollo A, Malvezzi M, Houtman JC, Accardi A. Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters Nat Struct Mol Biol, Dec 2009 PMID: 19898476
  105. Jacobson EM, Yang H, Menconi F, Wang R, Osman R, Skrabanek L, Li CW, Fadlalla M, Gandhi A, Chaturvedi V, Smith EP, Schwemberger S, Osterburg A, Babcock GF, Tomer Y. Employing a Recombinant HLA-DR3 Expression System to Dissect Major Histocompatibility Complex II-Thyroglobulin Peptide Dynamism J Biol Chem, Dec 2009 PMID: 19776016
  106. Mu P, Han YC, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D'Andrea A, Sander C, Ventura A. Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas Genes Devel, Dec 2009 PMID: 20008931
  107. Thompson AN, Kim I, Panosian TD, Iverson TM, Allen TW, Nimigean CM. Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore Nat Struct Mol Biol, Dec 2009 PMID: 19946269
  108. Goodarzi H, Elemento O, Tavazoie S. Revealing Global Regulatory Perturbations across Human Cancers Mol Cell, Dec 2009 PMID: 20005852
  109. Zhao Y, Quick M, Shi L, Mehler EL, Weinstein H, Javitch JA. Substrate-dependent proton antiport in neurotransmitter:sodium symporters Nat Chem Biol, Dec 2009 PMID: 20081826
  110. Hurtado R, Bub G, Herzlinger D. The pelvis–kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis Kidney Intl, Dec 2009 PMID: 20032965
  111. Weinstein AM. A Mathematical Model of Rat Ascending Henle Limb: I. Cotransporter Function Am J Physiol Renal Physiol, Nov 2009 PMID: 19923415
  112. Weinstein AM, Krahn TA. A Mathematical Model of Rat Ascending Henle Limb: II. Epithelial Function Am J Physiol Renal Physiol, Nov 2009 PMID: 19923414
  113. Weinstein AM. A Mathematical Model of Rat Ascending Henle Limb: III. Tubular Function Am J Physiol Renal Physiol, Nov 2009 PMID: 19923413
  114. Ahrens-Nicklas RC, Christini DJ. Anthropomorphizing the Mouse Cardiac Action Potential via a Novel Dynamic Clamp Method Biophys J, Nov 2009 PMID: 19917221
  115. Lundbaek JA, Collingwood SA, Ingólfsson HI, Kapoor R, Andersen OS. Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes J R Soc Interface, Nov 2009 PMID: 19940001
  116. Frindt G, Palmer LG. Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium Am J Physiol Renal Physiol, Nov 2009 PMID: 19741015
  117. Figueroa ME, Skrabanek L, Li Y, Jiemjit A, Fandy TE, Paietta E, Fernandez H, Tallman MS, Greally JM, Carraway H, Licht JD, Gore SD, Melnick A. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation Blood, Oct 2009 PMID: 19652201
  118. Yu F, Sun L, Machaca K. Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis PNAS, Oct 2009 PMID: 19805124
  119. Chen L, Zhang JJ, Rafii S, Huang XY. Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency J Biol Chem, Oct 2009 PMID: 19654325
  120. Khelashvili G, Harries D, Weinstein H. Modeling Membrane Deformations and Lipid Demixing upon Protein-Membrane Interaction: The BAR Dimer Adsorption Biophys J, Sep 2009 PMID: 19751667
  121. Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation Nat Chem Biol, Aug 2009 PMID: 19648932
  122. Sackin H, Nanazashvili M, Li H, Palmer LG, Walters DE. An intersubunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1 Biophys J, Aug 2009 PMID: 19686653
  123. Frindt G, Palmer LG. K+ secretion in the rat kidney: Na+ channel-dependent and -independent mechanisms Am J Physiol Renal Physiol, Aug 2009 PMID: 19474187
  124. Munro JB, Sanbonmatsu KY, Spahn CM, Blanchard SC. Navigating the ribosome’s metastable energy landscape Trends Biochem Sci, Aug 2009 PMID: 19647434
  125. Gaeta SA, Bub G, Abbott GW, Christini DJ. Dynamical Mechanism for Subcellular Alternans in Cardiac Myocytes Circ Res, Jul 2009 PMID: 19628792
  126. Sun L, Haun S, Jones RC, Edmondson RD, Machaca K. Kinase-dependent regulation of inositol 1,4,5-trisphosphate-dependent Ca2+ release during oocyte maturation J Biol Chem, Jul 2009 PMID: 19473987
  127. Maoz A, Krogh-Madsen T, Christini DJ. Instability in action potential morphology underlies phase 2 reentry: A mathematical modeling study Heart Rhythm, Jun 2009 PMID: 19467510
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