Physiology, the oldest and most fundamental of the basic medical sciences, is the science of the function of living organisms, including humans. In the Department of Physiology and Biophysics, our techniques are modern and are constantly evolving, our questions are immediate, but our basic quest remains constant. As Physiologists we ask how biological processes - from molecules to organisms - perform their functions. As Biophysicists we ask how these processes - and life itself - build upon the laws of mathematics, physics, and chemistry.

Recent publications by members of the Department of Physiology and Biophysics:
  1. Veerappan A, Reid AC, O'Connor N, Mora R, Brazin JA, Estephan R, Kameue T, Chen J, Felsen D, Seshan SV, Poppas DP, Maack T, Silver RB. Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model Am J Physiol Renal Physiol, Jan 2012 PMID: 21957176
  2. Frindt G, Palmer LG. Regulation of epithelial Na+ channels by adrenal steroids: mineralocorticoid and glucocorticoid effects Am J Physiol Renal Physiol, Jan 2012 PMID: 22012806
  3. Suresh A, Vannan M, Kumaran D, Gümüs ZH, Sivadas P, Murugaian EE, Kekatpure V, Iyer S, Thangaraj K, Kuriakose MA. Resistance/response molecular signature for oral tongue squamous cell carcinoma Dis Markers, Jan 2012 PMID: 22297602
  4. Wang L, Altman RB, Blanchard SC. Insights into the molecular determinants of EF-G catalyzed translocation RNA, Dec 2011 PMID: 22033333
  5. Edvinsson JM, Shah AJ, Palmer LG. Potassium-dependent activation of Kir4.2 K+ channels J Physiol, Dec 2011 PMID: 22025665
  6. Altman RB, Terry DS, Zhou Z, Zheng Q, Geggier P, Kolster RA, Zhao Y, Javitch JA, Warren JD, Blanchard SC. Cyanine fluorophore derivatives with enhanced photostability Nat Methods, Nov 2011 PMID: 22081126
  7. Mondal S, Khelashvili G, Shan J, Andersen OS, Weinstein H. Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors Biophys J, Nov 2011 PMID: 22067146
  8. Reid AC, Brazin JA, Morrey C, Silver RB, Levi R. Targeting cardiac mast cells: pharmacological modulation of the local renin-angiotensin system Curr Pharm Des, Nov 2011 PMID: 22103845
  9. Ingólfsson HI, Koeppe RE 2nd, Andersen OS. Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties FEBS Lett, Oct 2011 PMID: 21896274
  10. Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM. Structure and dynamics of the mammalian ribosomal pretranslocation complex Mol Cell, Oct 2011 PMID: 22017870
  11. Capetillo-Zarate E, Gracia L, Yu F, Banfelder JR, Lin MT, Tampellini D, Gouras GK. High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils Am J Pathol, Sep 2011 PMID: 21925470
  12. Ingólfsson HI, Andersen OS. Alcohol's effects on lipid bilayer properties Biophys J, Aug 2011 PMID: 21843475
  13. Greisen P Jr, Lum K, Ashrafuzzaman M, Greathouse DV, Andersen OS, Lundbæk JA. Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling PNAS, Aug 2011 PMID: 21768343
  14. Rusinova R, Herold KF, Sanford RL, Greathouse DV, Hemmings HC Jr, Andersen OS. Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery J Gen Physiol, Aug 2011 PMID: 21788612
  15. Frindt G, Houde V, Palmer LG. Conservation of Na+ vs. K+ by the rat cortical collecting duct Am J Physiol Renal Physiol, Jul 2011 PMID: 21454253
  16. Haller A, Rieder U, Aigner M, Blanchard SC, Micura R. Conformational capture of the SAM-II riboswitch Nat Chem Biol, Jun 2011 PMID: 21532598
  17. Ingólfsson HI, Li Y, Vostrikov VV, Gu H, Hinton JF, Koeppe RE 2nd, Roux B, Andersen OS. Gramicidin A backbone and side chain dynamics evaluated by molecular dynamics simulations and nuclear magnetic resonance experiments. I: molecular dynamics simulations J Phys Chem B, Jun 2011 PMID: 21574563
  18. Vostrikov VV, Gu H, Ingólfsson HI, Hinton JF, Andersen OS, Roux B, Koeppe RE 2nd. Gramicidin A backbone and side chain dynamics evaluated by molecular dynamics simulations and nuclear magnetic resonance experiments. II: nuclear magnetic resonance experiments J Phys Chem B, Jun 2011 PMID: 21574558
  19. Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homolog Nature, Jun 2011 PMID: 21516104
  20. Gu H, Lum K, Kim JH, Greathouse DV, Andersen OS, Koeppe RE 2nd. The membrane interface dictates different anchor roles for "inner pair" and "outer pair" tryptophan indole rings in gramicidin A channels Biochem, Jun 2011 PMID: 21539360
  21. Aaker GD, Gracia L, Myung JS, Borcherding V, Banfelder JR, D'Amico DJ, Kiss S. Three-dimensional reconstruction and analysis of vitreomacular traction: quantification of cyst volume and vitreoretinal interface area Arch Ophthalmol, Jun 2011 PMID: 21670354
  22. Edvinsson JM, Shah AJ, Palmer LG. Kir4.1 K+ channels are regulated by external cations Channels, May 2011 PMID: 21532341
  23. Andersen OS. Perspectives on: Ion selectivity J Gen Physiol, May 2011 PMID: 21518827
  24. Dunkle JA, Wang L, Feldman MB, Pulk A, Chen VB, Kapral GJ, Noeske J, Richardson JS, Blanchard SC, Cate JH. Structures of the bacterial ribosome in classical and hybrid states of tRNA binding Science, May 2011 PMID: 21596992
  25. Sackin H, Nanazashvili M, Li H, Palmer LG, Yang L. Modulation of Kir1.1 inactivation by extracellular Ca and Mg Biophys J, Mar 2011 PMID: 21354393
  26. Stember JN, Andersen O. A one-dimensional continuum elastic model for membrane-embedded gramicidin dimer dissociation PLoS One, Feb 2011 PMID: 21326605
  27. Cohen FS, Andersen OS. Cells on the MEND: exploring the role of lipidic forces in membrane trafficking J Gen Physiol, Feb 2011 PMID: 21242298
  28. Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJ, Li Y, Meyer S, Erpelinck-Verschueren C, Greally J, Löwenberg B, Melnick A, Delwel R. Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1 Blood, Jan 2011 PMID: 20855866
  29. He Y, Liwo A, Weinstein H, Scheraga HA. PDZ Binding to the BAR Domain of PICK1 is Elucidated by Coarse-grained Molecular Dynamics J Mol Biol, Jan 2011 PMID: 21050858
  30. Yu F, Sun L, Courjaret R, Machaca K. Role of the STIM1 C-terminal domain in STIM1 clustering J Biol Chem, Jan 2011 PMID: 21220431
  31. Safdieh JE, Lin AL, Aizer J, Marzuk PM, Grafstein B, Storey-Johnson C, Kang Y. Standardized patient outcomes trial (SPOT) in neurology Med Educ Online, Jan 2011 PMID: 21249174
  32. Snyder M, Huang XY, Zhang JJ. Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene FEBS Lett, Jan 2011 PMID: 21094641
  33. Grafstein B. Subverting the hegemony of the synapse: complicity of neurons, astrocytes, and vasculature in spreading depression and pathology of the cerebral cortex Brain Res Rev, Jan 2011 PMID: 20888859
  34. Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. The binding sites for benztropines and dopamine in the dopamine transporter overlap Neuropharm, Jan 2011 PMID: 20816875
  35. Shan J, Javitch JA, Shi L, Weinstein H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter PLoS One, Jan 2011 PMID: 21298009
  36. Shi L, Weinstein H. Conformational Rearrangements to the Intracellular Open States of the LeuT and ApcT Transporters Are Modulated by Common Mechanisms Biophys J, Dec 2010 PMID: 21156121
  37. Munro JB, Wasserman MR, Altman RB, Wang L, Blanchard SC. Correlated conformational events in EF-G and the ribosome regulate translocation Nat Struct Mol Biol, Dec 2010 PMID: 21057527
  38. Yang L, Frindt G, Palmer LG. Magnesium modulates ROMK channel-mediated potassium secretion J Am Soc Nephrol, Dec 2010 PMID: 21030597
  39. Shan J, Weinstein H, Mehler EL. Probing the structural determinants for the function of intracellular loop 2 in structurally cognate g-protein-coupled receptors Biochem, Dec 2010 PMID: 21062002
  40. Machaca K. Ca(2+) signaling, genes and the cell cycle Cell Calcium, Nov 2010 PMID: 21084120
  41. Yu F, Sun L, Machaca K. Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis JCB, Nov 2010 PMID: 21041445
  42. Li Y, Andersen OS, Roux B. Energetics of double-ion occupancy in the gramicidin A channel J Phys Chem B, Nov 2010 PMID: 20939567
  43. Frindt G, Palmer LG. Effects of dietary K on cell-surface expression of renal ion channels and transporters Am J Physiol Renal Physiol, Oct 2010 PMID: 20702602
  44. Morrey C, Brazin J, Seyedi N, Corti F, Silver RB, Levi R. Interaction between sensory C-fibers and cardiac mast cells in ischemia/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction J Pharmacol Exp Ther, Oct 2010 PMID: 20668055
  45. Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1 Org Biomol Chem, Oct 2010 PMID: 20668766
  46. Khelashvili G, Mondal S, Andersen OS, Weinstein H. Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors J Phys Chem B, Sep 2010 PMID: 20804205
  47. Yu H, Mazzanti CL, Whitfield TW, Koeppe RE, Andersen OS, Roux B. A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide J Am Chem Soc, Aug 2010 PMID: 20681718
  48. Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R. Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells Circulation, Aug 2010 PMID: 20697027
  49. Lundbaek JA, Koeppe RE 2nd, Andersen OS. Amphiphile regulation of ion channel function by changes in the bilayer spring constant PNAS, Aug 2010 PMID: 20713738
  50. Accardi A, Picollo A. CLC channels and transporters: proteins with borderline personalities Biochim Biophys Acta., Aug 2010 PMID: 20188062
  51. Daily AE, Kim JH, Greathouse DV, Andersen OS, Koeppe RE 2nd. Polar groups in membrane channels: consequences of replacing alanines with serines in membrane-spanning gramicidin channels Biochem, Aug 2010 PMID: 20695525
  52. Schreiner R, Frindt G, Diaz F, Carvajal-Gonzalez JM, Perez Bay AE, Palmer LG, Marshansky V, Brown D, Philp NJ, Rodriguez-Boulan E. The absence of a clathrin adapter confers unique polarity essential to proximal tubule function Kidney Intl, Aug 2010 PMID: 20531453
  53. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base Bioinf, Jul 2010 PMID: 20501551
  54. Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS. Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters Nat Struct Mol Biol, Jul 2010 PMID: 20562855
  55. Arredouani A, Yu F, Sun L, Machaca K. Regulation of store-operated Ca2+ entry during the cell cycle J Cell Sci, Jul 2010 PMID: 20554894
  56. Snyder M, Huang XY, Zhang JJ. Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells J Biol Chem, Jul 2010 PMID: 20522556
  57. Whitford PC, Geggier P, Altman RB, Blanchard SC, Onuchic JN, Sanbonmatsu KY. Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways RNA, Jun 2010 PMID: 20427512
  58. B Grafstein. Axonal Transport: The Intracellular Traffic of the Neuron Comprehensive Physiology, Jun 2010
  59. Geggier P, Dave R, Feldman MB, Terry DS, Altman RB, Munro JB, Blanchard SC. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome J Mol Biol, Jun 2010 PMID: 20434456
  60. Blanchard SC, Cooperman BS, Wilson DN. Probing translation with small-molecule inhibitors Chem Biol, Jun 2010 PMID: 20609413
  61. Picollo A, Malvezzi M, Accardi A. Proton block of the CLC-5 Cl-/H+ exchanger JGP, Jun 2010 PMID: 20513761
  62. Sackin H, Nanazashvili M, Li H, Palmer LG, Walters DE. A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity Channels, May 2010 PMID: 20458182
  63. Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. Single-molecule dynamics of gating in a neurotransmitter transporter homologue Nature, May 2010 PMID: 20463731
  64. Brass LF, Akabas MH, Burnley LD, Engman DM, Wiley CA, Andersen OS. Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs Acad Med, Apr 2010 PMID: 20186033
  65. Chen L, Yang S, Jakoncic J, Zhang JJ, Huang XY. Migrastatin analogues target fascin to block tumour metastasis Nature, Apr 2010 PMID: 20393565
  66. Boyle JO, Gümüs ZH, Kacker A, Choksi VL, Bocker JM, Zhou XK, Yantiss RK, Hughes DB, Du B, Judson BL, Subbaramaiah K, Dannenberg AJ. Effects of Cigarette Smoke on the Human Oral Mucosal Transcriptome Cancer Prev Res, Mar 2010 PMID: 20179299
  67. Ge X, Roux B. Calculation of the standard binding free energy of sparsomycin to the ribosomal peptidyl-transferase P-site using molecular dynamics simulations with restraining potentials J Mol Recog, Feb 2010 PMID: 20151411
  68. Zeynep H. Gümüş, Fernando Siso-Nadal, Ada Gjyrezi, Paul McDonagh, Iya Khalil, Paraskevi Giannakakou and Harel Weinstein. Quantification and analysis of combination drug synergy in high-throughput transcriptome studies IEEE Conf. Bioinf. Bioeng., Feb 2010
  69. Ingólfsson HI, Andersen OS. Screening for Small Molecules’ Bilayer- Modifying Potential Using a Gramicidin-Based Fluorescence Assay Assay Drug Devel Tech, Feb 2010 PMID: 20233091
  70. Guo D, Zhang JJ, Huang XY. A new Rac/PAK/GC/cGMP signaling pathway Mol Cell Biol, Jan 2010 PMID: 19937092
  71. Feldman MB, Terry DS, Altman RB, Blanchard SC. Aminoglycoside activity observed on single pre-translocation ribosome complexes Nat Chem Biol, Jan 2010 PMID: 19946275
  72. Figueroa ME, Lugthart S, Li Y, Erpelinck-Verschueren C, Deng X, Christos PJ, Schifano E, Booth J, van Putten W, Skrabanek L, Campagne F, Mazumdar M, Greally JM, Valk PJ, Löwenberg B, Delwel R, Melnick A. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia Cancer Cell, Jan 2010 PMID: 20060365
  73. Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, Rønn LC, Gether U. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD PNAS, Jan 2010 PMID: 20018661
  74. Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, Blobel CP. Pathological Neovascularization Is Reduced by Inactivation of ADAM17 in Endothelial Cells but Not in Pericytes Circ Res, Jan 2010 PMID: 20110534
  75. Munro JB, Altman RB, Tung CS, Cate JH, Sanbonmatsu KY, Blanchard SC. Spontaneous formation of the unlocked state of the ribosome is a multistep process PNAS, Jan 2010 PMID: 20018653
  76. Munro JB, Altman RB, Tung CS, Sanbonmatsu KY, Blanchard SC. A fast dynamic mode of the EF-G-bound ribosome EMBO J, Dec 2009 PMID: 20033061
  77. Picollo A, Malvezzi M, Houtman JC, Accardi A. Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters Nat Struct Mol Biol, Dec 2009 PMID: 19898476
  78. Jacobson EM, Yang H, Menconi F, Wang R, Osman R, Skrabanek L, Li CW, Fadlalla M, Gandhi A, Chaturvedi V, Smith EP, Schwemberger S, Osterburg A, Babcock GF, Tomer Y. Employing a Recombinant HLA-DR3 Expression System to Dissect Major Histocompatibility Complex II-Thyroglobulin Peptide Dynamism J Biol Chem, Dec 2009 PMID: 19776016
  79. Mu P, Han YC, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D'Andrea A, Sander C, Ventura A. Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas Genes Devel, Dec 2009 PMID: 20008931
  80. Goodarzi H, Elemento O, Tavazoie S. Revealing Global Regulatory Perturbations across Human Cancers Mol Cell, Dec 2009 PMID: 20005852
  81. Zhao Y, Quick M, Shi L, Mehler EL, Weinstein H, Javitch JA. Substrate-dependent proton antiport in neurotransmitter:sodium symporters Nat Chem Biol, Dec 2009 PMID: 20081826
  82. Hurtado R, Bub G, Herzlinger D. The pelvis–kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis Kidney Intl, Dec 2009 PMID: 20032965
  83. Weinstein AM. A Mathematical Model of Rat Ascending Henle Limb: I. Cotransporter Function Am J Physiol Renal Physiol, Nov 2009 PMID: 19923415
  84. Weinstein AM, Krahn TA. A Mathematical Model of Rat Ascending Henle Limb: II. Epithelial Function Am J Physiol Renal Physiol, Nov 2009 PMID: 19923414
  85. Weinstein AM. A Mathematical Model of Rat Ascending Henle Limb: III. Tubular Function Am J Physiol Renal Physiol, Nov 2009 PMID: 19923413
  86. Ahrens-Nicklas RC, Christini DJ. Anthropomorphizing the Mouse Cardiac Action Potential via a Novel Dynamic Clamp Method Biophys J, Nov 2009 PMID: 19917221
  87. Lundbaek JA, Collingwood SA, Ingólfsson HI, Kapoor R, Andersen OS. Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes J R Soc Interface, Nov 2009 PMID: 19940001
  88. Frindt G, Palmer LG. Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium Am J Physiol Renal Physiol, Nov 2009 PMID: 19741015
  89. Figueroa ME, Skrabanek L, Li Y, Jiemjit A, Fandy TE, Paietta E, Fernandez H, Tallman MS, Greally JM, Carraway H, Licht JD, Gore SD, Melnick A. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation Blood, Oct 2009 PMID: 19652201
  90. Yu F, Sun L, Machaca K. Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis PNAS, Oct 2009 PMID: 19805124
  91. Chen L, Zhang JJ, Rafii S, Huang XY. Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency J Biol Chem, Oct 2009 PMID: 19654325
  92. Khelashvili G, Harries D, Weinstein H. Modeling Membrane Deformations and Lipid Demixing upon Protein-Membrane Interaction: The BAR Dimer Adsorption Biophys J, Sep 2009 PMID: 19751667
  93. Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation Nat Chem Biol, Aug 2009 PMID: 19648932
  94. Sackin H, Nanazashvili M, Li H, Palmer LG, Walters DE. An intersubunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1 Biophys J, Aug 2009 PMID: 19686653
  95. Frindt G, Palmer LG. K+ secretion in the rat kidney: Na+ channel-dependent and -independent mechanisms Am J Physiol Renal Physiol, Aug 2009 PMID: 19474187
  96. Munro JB, Sanbonmatsu KY, Spahn CM, Blanchard SC. Navigating the ribosome’s metastable energy landscape Trends Biochem Sci, Aug 2009 PMID: 19647434
  97. Gaeta SA, Bub G, Abbott GW, Christini DJ. Dynamical Mechanism for Subcellular Alternans in Cardiac Myocytes Circ Res, Jul 2009 PMID: 19628792
  98. Sun L, Haun S, Jones RC, Edmondson RD, Machaca K. Kinase-dependent regulation of inositol 1,4,5-trisphosphate-dependent Ca2+ release during oocyte maturation J Biol Chem, Jul 2009 PMID: 19473987
  99. Maoz A, Krogh-Madsen T, Christini DJ. Instability in action potential morphology underlies phase 2 reentry: A mathematical modeling study Heart Rhythm, Jun 2009 PMID: 19467510
  100. Roudi Y, Nirenberg S, Latham PE. Pairwise Maximum Entropy Models for Studying Large Biological Systems: When They Can Work and When They Can’t PLoS Comp Biol, May 2009 PMID: 19424487
  101. Goldberg DH, Victor JD, Gardner EP, Gardner D. Spike Train Analysis Toolkit: Enabling Wider Application of Information-Theoretic Techniques to Neurophysiology Neuroinf, May 2009 PMID: 19475519
  102. Guo D, Zhang JJ, Huang XY. Stimulation of guanylyl cyclase-D by bicarbonate Biochem, May 2009 PMID: 19331426
  103. Snyder M, Huang XY, Zhang JJ. The Minichromosome Maintenance Proteins 2-7 (MCM2-7) Are Necessary for RNA Polymerase II (Pol II)-mediated Transcription J Biol Chem, May 2009 PMID: 19318354
  104. Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA. Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation PNAS, Apr 2009 PMID: 19307590
  105. Jacobs AL, Fridman G, Douglas RM, Alam NM, Latham PE, Prusky GT, Nirenberg S. Ruling out and ruling in neural codes PNAS, Apr 2009 PMID: 19297621
  106. Dave R, Terry DS, Munro JB, Blanchard SC. Mitigating Unwanted Photophysical Processes for Improved Single-Molecule Fluorescence Imaging Biophys J, Mar 2009 PMID: 19289062
  107. Ahrens-Nicklas RC, Clancy CE, Christini DJ. Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling Cardiovascular Research, Mar 2009 PMID: 19264765
  108. Topisirovic I, Siddiqui N, Orolicki S, Skrabanek LA, Tremblay M, Hoang T, Borden KL. Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated by HuR, and This Activity Is Dysregulated in Cancer Mol Cell Biol, Mar 2009 PMID: 19114552
  109. Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, Ye K, Farinha P, Horsman DE, Gascoyne RD, Elemento O, Melnick A. The BCL6 transcriptional program features repression of multiple oncogenes in primary B-cells and is deregulated in DLBCL Blood, Mar 2009 PMID: 19307668
  110. Automatic Determination of Stepsize Parameters in Monte Carlo Simulation Tested on a Bromodomain-Binding Octapeptide Algorithms, Feb 2009
  111. Counting complex disordered states by efficient pattern matching: chromatic polynomials and Potts partition functions New J Phys, Feb 2009
  112. Yang S, Zhang JJ, Huang XY. Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis Cancer Cell, Feb 2009 PMID: 19185847
  113. Blanchard SC. Single-molecule observations of ribosome function Curr Opin Struct Biol, Feb 2009 PMID: 19223173
  114. Blanchard SC. When Starting Over Makes More Sense ACS Chem Biol, Feb 2009 PMID: 19228069
  115. Wang GJ, Brenner-Anantharam A, Vaughan ED, Herzlinger D. Antagonism of BMP4 Signaling Disrupts Smooth Muscle Investment of the Ureter and Ureteropelvic Junction J Urology, Jan 2009 PMID: 19010499
  116. Figueroa ME, Wouters BJ, Skrabanek L, Glass J, Li Y, Erpelinck-Verschueren CA, Langerak AW, Löwenberg B, Fazzari M, Greally JM, Valk PJ, Melnick A, Delwel R. Genome wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features Blood, Jan 2009 PMID: 19168792
  117. Legesse-Miller A, Elemento O, Pfau SJ, Forman JJ, Tavazoie S, Coller HA. let-7 overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34 and stabilization of Wee1 kinase in primary fibroblasts J Biol Chem, Jan 2009 PMID: 19126550