Christopher Mendias, Ph.D.

Associate Professor of Physiology and Biophysics

  • Associate Professor of Physiology and Biophysics in Orthopaedic Surgery (primary appointment)
  • Associate Scientist, Hospital for Special Surgery

212-606-1785

515 East 71st Street, Room S-602
New York, NY 10021

 

 


Techniques

Research Areas


Research Summary:

We conduct bench to bedside research focused on the basic cellular and molecular mechanisms that underlie musculoskeletal injury and regeneration, and in the development of new therapeutic approaches to treat these conditions. A particular focus is on the cellular and molecular mechanisms of skeletal muscle atrophy, and the mechanbiology of musculoskeletal connective tissue growth and fibrosis. We take an integrative, systems biology approach in our studies, utilizing molecular genetics, sequencing, signal transduction, mass spectrometry proteomics/metabolomics, and bioinformatics techniques, along with physiological assessments of tissue function.

Recent Publications:

 

  1. Talarek, JR, Piacentini, AN, Konja, AC, Wada, S, Swanson, JB, Nussenzweig, SC et al.. The MRL/MpJ mouse strain is not protected from muscle atrophy and weakness after rotator cuff tear. J. Orthop. Res. 2019; :. doi: 10.1002/jor.24516. PubMed PMID:31696955 .
  2. Disser, NP, Sugg, KB, Talarek, JR, Sarver, DC, Rourke, BJ, Mendias, CL et al.. Insulin-like growth factor 1 signaling in tenocytes is required for adult tendon growth. FASEB J. 2019;33 (11):12680-12695. doi: 10.1096/fj.201901503R. PubMed PMID:31536390 .
  3. Mendias, CL, Bedi, A. RE: Talks BJ, Fernquest S, Palmer A, et al. 2019. No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement. J. Orthop. Res. 2019;37 (12):2621-2622. doi: 10.1002/jor.24427. PubMed PMID:31343771 .
  4. Gok, E, Alghanem, F, Lim, E, Sarver, D, Eckhardt, L, Christensen, S et al.. Single Muscle Fibre Contractility Testing in Rats to Quantify Ischaemic Muscle Damage During Reperfusion Injury. Eur J Vasc Endovasc Surg. 2019;58 (2):249-256. doi: 10.1016/j.ejvs.2019.01.009. PubMed PMID:31202581 .
  5. Gumucio, JP, Qasawa, AH, Ferrara, PJ, Malik, AN, Funai, K, McDonagh, B et al.. Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis. FASEB J. 2019;33 (7):7863-7881. doi: 10.1096/fj.201802457RR. PubMed PMID:30939247 PubMed Central PMC6593892.
  6. Pataky, MW, Yu, CS, Nie, Y, Arias, EB, Singh, M, Mendias, CL et al.. Skeletal muscle fiber type-selective effects of acute exercise on insulin-stimulated glucose uptake in insulin-resistant, high-fat-fed rats. Am. J. Physiol. Endocrinol. Metab. 2019;316 (5):E695-E706. doi: 10.1152/ajpendo.00482.2018. PubMed PMID:30753114 PubMed Central PMC6580167.
  7. Schubert, MF, Noah, AC, Bedi, A, Gumucio, JP, Mendias, CL. Reduced Myogenic and Increased Adipogenic Differentiation Capacity of Rotator Cuff Muscle Stem Cells. J Bone Joint Surg Am. 2019;101 (3):228-238. doi: 10.2106/JBJS.18.00509. PubMed PMID:30730482 .
  8. Ahtiainen, JP, Lensu, S, Ruotsalainen, I, Schumann, M, Ihalainen, JK, Fachada, V et al.. Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training. Exp. Physiol. 2018;103 (11):1513-1523. doi: 10.1113/EP087144. PubMed PMID:30184287 PubMed Central PMC6519084.
  9. Syverud, BC, Gumucio, JP, Rodriguez, BL, Wroblewski, OM, Florida, SE, Mendias, CL et al.. A Transgenic tdTomato Rat for Cell Migration and Tissue Engineering Applications. Tissue Eng Part C Methods. 2018;24 (5):263-271. doi: 10.1089/ten.TEC.2017.0406. PubMed PMID:29490563 PubMed Central PMC5946766.
  10. Gumucio, JP, Sugg, KB, Enselman, ERS, Konja, AC, Eckhardt, LR, Bedi, A et al.. Anterior cruciate ligament tear induces a sustained loss of muscle fiber force production. Muscle Nerve. 2018; :. doi: 10.1002/mus.26075. PubMed PMID:29346717 PubMed Central PMC6051936.
  11. Sugg, KB, Markworth, JF, Disser, NP, Rizzi, AM, Talarek, JR, Sarver, DC et al.. Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling. Am. J. Physiol., Cell Physiol. 2018;314 (4):C389-C403. doi: 10.1152/ajpcell.00258.2017. PubMed PMID:29341790 PubMed Central PMC5966786.
  12. Mead, MP, Gumucio, JP, Awan, TM, Mendias, CL, Sugg, KB. Pathogenesis and Management of Tendinopathies in Sports Medicine. Transl Sports Med. 2018;1 (1):5-13. doi: 10.1002/tsm2.6. PubMed PMID:31131372 PubMed Central PMC6530902.
  13. Lee, S, Gumucio, J, Mendias, C, Bedi, A. What is the role of systemic conditions and options for manipulation of bone formation and bone resorption in rotator cuff tendon healing and repair?. Tech Shoulder Elb Surg. 2017;18 (3):113-120. doi: 10.1097/BTE.0000000000000121. PubMed PMID:28966557 PubMed Central PMC5615853.
  14. Novakova, SS, Mahalingam, VD, Florida, SE, Mendias, CL, Allen, A, Arruda, EM et al.. Tissue-engineered tendon constructs for rotator cuff repair in sheep. J. Orthop. Res. 2018;36 (1):289-299. doi: 10.1002/jor.23642. PubMed PMID:28657154 .
  15. Mendias, CL. Fibroblasts take the centre stage in human skeletal muscle regeneration. J. Physiol. (Lond.). 2017;595 (15):5005. doi: 10.1113/JP274403. PubMed PMID:28585689 PubMed Central PMC5538237.
  16. Sarver, DC, Sugg, KB, Disser, NP, Enselman, ERS, Awan, TM, Mendias, CL et al.. Local cryotherapy minimally impacts the metabolome and transcriptome of human skeletal muscle. Sci Rep. 2017;7 (1):2423. doi: 10.1038/s41598-017-02754-5. PubMed PMID:28546635 PubMed Central PMC5445066.
  17. Saripalli, AL, Sugg, KB, Mendias, CL, Brooks, SV, Claflin, DR. Active shortening protects against stretch-induced force deficits in human skeletal muscle. J. Appl. Physiol. 2017;122 (5):1218-1226. doi: 10.1152/japplphysiol.01054.2016. PubMed PMID:28235860 PubMed Central PMC5451535.
  18. Werner, NL, Alghanem, F, Rakestraw, SL, Sarver, DC, Nicely, B, Pietroski, RE et al.. Ex Situ Perfusion of Human Limb Allografts for 24 Hours. Transplantation. 2017;101 (3):e68-e74. doi: 10.1097/TP.0000000000001500. PubMed PMID:28222055 .
  19. Wurtzel, CN, Gumucio, JP, Grekin, JA, Khouri, RK Jr, Russell, AJ, Bedi, A et al.. Pharmacological inhibition of myostatin protects against skeletal muscle atrophy and weakness after anterior cruciate ligament tear. J. Orthop. Res. 2017;35 (11):2499-2505. doi: 10.1002/jor.23537. PubMed PMID:28176368 PubMed Central PMC5548641.
  20. Sugg, KB, Korn, MA, Sarver, DC, Markworth, JF, Mendias, CL. Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy. FEBS Lett. 2017;591 (5):801-809. doi: 10.1002/1873-3468.12571. PubMed PMID:28129672 PubMed Central PMC5352504.
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Selected Publications:

 

  1. Mendias CL, Bakhurin KI, Gumucio JP, Shallal-Ayzin MV, Davis CS, Faulkner JA. Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice. Aging Cell. 2015 Aug;14(4):704-6.
  2. Mendias CL, Lynch EB, Gumucio JP, Flood MD, Rittman DS, Van Pelt DW, Roche SM, Davis CS. Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats. J Physiol. 2015 Apr 15;593(8):2037-52.
  3. Schwartz AJ, Sarver DC, Sugg KB, Dzierzawski JT, Gumucio JP, Mendias CL. p38 MAPK signaling in postnatal tendon growth and remodeling. PLoS One. 2015 Mar 13;10(3):e0120044. doi: 10.1371/journal.pone.0120044. eCollection 2015.
  4. Fry CS, Lee JD, Mula J, Kirby TJ, Jackson JR, Liu F, Yang L, Mendias CL, Dupont-Versteegden EE, McCarthy JJ, Peterson CA. Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nat Med. 2015 Jan;21(1):76-80. doi: 10.1038/nm.3710.
  5. Gumucio JP, Phan AC, Ruehlmann DG, Noah AC, Mendias CL. Synergist ablation induces rapid tendon growth through the synthesis of a neotendon matrix. J Appl Physiol (1985). 2014 Dec 1;117(11):1287-91.
  6. Mendias CL, Bakhurin KI, Faulkner JA. Tendons of myostatin-deficient mice are small, brittle, and hypocellular. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):388-93.