Quantitative Understanding in Biology
Q3-Q4 2012

Home | Schedule and Lecture Notes | Prerequisites | Grading

Tuesdays, 5:00 pm – 6:30 pm
Wednesdays, 4:00 pm – 5:30 pm
Location: Weill Greenberg Center (1305 York Avenue); 13th Floor ICB Conf Room, Y.13.01

Module I: Statistics

Tue 24-Jan: Welcome; Quantifying a Sample Distribution (lecture notes)
Wed 25-Jan: Probability Density Functions and the Normal Distribution (lecture notes)
Tue 31-Jan: Confidence Intervals and Contingency Tables (lecture notes)
Web 1-Feb: P-Values and Formal Statistical Tests (lecture notes)
Tue 7-Feb: Statistical Power and Experimental Design (lecture notes)
Wed 8-Feb: Multiple Hypothesis Testing and Non-Parametric Tests (lecture notes)
Tue 14-Feb: Statistics Computer Laboratory (problem statement; data will be provided in class or via email upon request -- bring your laptop)
Wed 15-Feb: SPECIAL TOPICS FACULTY LECTURE: Dr. Glen Prusky
Tue 21-Feb: SPECIAL TOPICS FACULTY LECTURE: Dr. Christopher Mason (slides)
Wed 22-Feb: No Class -- recruitment days

Module II: Model Parameter Estimation

Tue 28-Feb: Correlation and Linear Regression (lecture notes)
Wed 29-Feb: Fitting Model Parameters to Data (lecture notes)
Tue 6-Mar: Quantitative Comparison of Models (lecture notes); Statistics Computer Lab due
Wed 7-Mar: SPECIAL TOPICS FACULTY LECTURE: Dr. Olivier Elemento (slides)
Tue 13-Mar: Parameter Estimation Computer Laboratory (problem statement)
Wed 14-Mar: SPECIAL TOPICS FACULTY LECTURE: Dr. Zeynep Gumus (slides)

Intermission

Tue 20-Mar: No Class
Wed 21-Mar: (4:00 PM - 7:00 PM): Midterm Exam (the exam will be held in LC-504, the Physiology conference room, 1300 York Ave, 5th floor) -- (prior midterm exams are available: 2008, 2009, 2010, 2011)
Tue 27-Mar: (4:00 PM - 5:30 PM): SPECIAL TOPICS FACULTY LECTURE: Machine Learning Methods in Biology -- Dr. Christina Leslie
Wed 28-Mar:SPECIAL TOPICS LABORATORY: Machine Learning Methods in Biology
Tue 3-Apr: No Class (Spring Break Holiday)
Wed 4-Apr: No Class (Spring Break Holiday)

Module III: Linear Difference Equations and Linear Algebra

Tue 10-Apr: Introduction to Dynamic Systems and Linear Difference Equations (lecture notes); Model Parameter Estimation Lab due
Wed 11-Apr: Periodic Behavior and Complex Eigenvalues (lecture notes)
Tue 17-Apr: No Class (du Vigneaud Symposium)
Wed 18-Apr: A First Look at Eigenvectors (lecture notes)
Tue 24-Apr: No Class
Wed 25-Apr: Principal Component Analysis (lecture notes)
Tue 1-May: Linear Difference Equations Laboratory (problem statement)

Module IV: Dynamical Systems and Ordinary Differential Equations

Tue 1-May: Representing Time Dependent Phenomena with ODEs (lecture notes)
Wed 2-May Stability and Linearization of ODEs -- part I (lecture notes)
Tue 8-May: Stability and Linearization of ODEs -- part II (same notes as above)
Wed 9-May: ODE Laboratory (problem statement); Introduction to Markov Chains and Hidden Markov Models (lecture notes)
Tue 15-May: SPECIAL TOPICS FACULTY LECTURE: Voltage Gated Channels -- Dr. Trine Krogh-Madsen (slides)
Wed 16-May: SPECIAL TOPICS LABORATORY: Voltage Gated Channels -- Dr. Trine Krogh-Madsen(lab writeup; files to download: LR1.m, LR1_alternans.m, LR1_crtl.m)
Tue 22-May: No class; Difference Equations Lab due
Wed 23-May: No class

Conclusion

Tue 29-May: Students’ Final Project Presentations
Wed 30-May: Students’ Final Project Presentations
Fri 1-Jun: ODE lab due
Tue 5-Jun: No Class
Wed 6-Jun (4:00 PM - 7:00 PM): Final Exam (the exam will be held in LC-504, the Physiology conference room, 1300 York Ave, 5th floor) -- prior final exams are available (2008, 2009, 2010, 2011); Final Project Report due