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Helgi I. Ingólfsson Post-Doctoral Fellow E-mail:  |
Position:
| Post-Doctoral Fellow at the Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY |
Synopsis of Current Resarch:
| I am studying to what extent the lipid bilayer component of biological membranes may serve as an allosteric regulator of membrane protein function. How do changes in bilayer properties alter membrane protein function, specifically how do changes in lipid bilayer mechanical properties propagate into changes in protein function? To do so, I examine how small amphipathic molecules induce changes in bilayer physical properties: its domain structure; thickness; elastic moduli; and intrinsic curvature. I do so using gramicidin channels of different lengths as force transducers to quantify the force the bilayer can impose on a membrane-spanning channel, in order to relate changes in bilayer properties (as summarized by the disjoining force the bilayer imposes on gramicidin channels of different lengths) to changes in membrane protein function. |
Education/Training:
| Institution and Location | Degree | Year(s) | Field of Study |
|---|---|---|---|
| University of Iceland, Iceland | B.S. | 1999-2002 | Computer Science |
| Cornell University, Ithaca, NY | M.S. | 2003-2005 | Computer Science |
| Weill Medical College of Cornell University, New York, NY | PhD. | 2005-2010 | Computational biology / Biophysics |
Awards:
| 2003-2008 | Fulbright Doctoral Fellowship |
| 2003-2008 | Tri-Institutional Fellowship in Computational Biology and Medicine, Cornell University, Rockefeller University, Sloan Kettering Institute |
| 2010 | Student Research Achievement Award, Biophysical Society's 54rd Annual Meeting |
| 2010 | Student Travel Award, Biophysical Society's 54rd Annual Meeting |
Publications:
- Ingólfsson HI and Andersen OS. Screening for Small Molecules' Bilayer-Modifying Potential Using a Gramicidin-Based Fluorescence Assay. Assay Drug Dev Technol. Epub (2010).
< Full Text > | < PubMed > - Ingólfsson HI. Amphiphile effects on membrane properties as sensed by membrane spanning proteins: screening for off-target drug effects. PhD thesis, Cornell University. (2010).
- Lundbæk JA, Collingwood SA, Ingólfsson HI, Kapoor R and Andersen OS. Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. J R Soc Interface. 7(44):373-95 (2010).
< Full Text > | < PubMed > - Andersen OS, Ingólfsson HI and Lundbæk JA. Ion Channels. In Wiley Encyclopedia of Chemical Biology. John Wiley & Sons, Inc. (2008).
- Kapoor R, Kim JH, Ingólfsson HI and Andersen OS. Preparation of artificial bilayers for electrophysiology experiments. J Vis Exp. (20). pii: 1033. doi: 10.3791/1033 (2008).
< Video Link > | < PubMed > - Ingólfsson HI, Kapoor R, Collingwood SA and Andersen OS. Single molecule methods for monitoring changes in bilayer elastic properties. J Vis Exp. (21). pii: 1032. doi: 10.3791/1032 (2008).
< Video Link > | < PubMed > - Ingólfsson HI, Koeppe RE II and Andersen OS. Curcumin is a modulator of bilayer material properties. Biochemistry. 11;46(36):10384-91 (2007).
< Abstract > | < PubMed > - Adachi S, Nagao T, Ingólfsson HI, Maxfield FR, Andersen OS, Kopelovich L and Weinstein IB. The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer Res. 67(13):6493-501. (2007).
< Full Text > | < PubMed > - Helgi Ingólfsson and Golan Yona. Protein domain prediction. In Structural Proteomics - High-throughput Methods, edited by M. Guss, T. Huber and B. Kobe. Humana press (2007).