Harel Weinstein

Recent Publications:
  1. Razavi AM, Khelashvili G, Weinstein H. A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter Nat Sci RepJan 2017 PMID: 28059145
  2. Cuendet MA, Weinstein H, LeVine MV. The Allostery Landscape: Quantifying Thermodynamic Couplings in Biomolecular Systems JCTCNov 2016 PMID: 27766843
  3. Sahai MA, Davidson C, Khelashvili G, Barrese V, Dutta N, Weinstein H, Opacka-Juffry J. Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances – The case of the benzofuran 5-MAPB J pnpbpNov 2016 PMID: 27890676
  4. Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H. Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290 J Biol ChemSep 2016 PMID: 27474737
  5. Zhao Y, Fay F, Hak S, Manuel Perez-Aguilar J, Sanchez-Gaytan BL, Goode B, Duivenvoorden R, de Lange Davies C, Bjørkøy A, Weinstein H, Fayad ZA, Pérez-Medina C, Mulder WJ. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nat CommunApr 2016 PMID: 27071376
  6. LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H. Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles BiochemFeb 2016 PMID: 26811944
  7. LeVine MV, Cuendet MA, Khelashvili G, Weinstein H. Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters Chem RevFeb 2016 PMID: 26892914
  8. Stolzenberg S, Michino M, LeVine MV, Weinstein H, Shi L. Computational approaches to detect allosteric pathways in transmembrane molecular machines Biochim Biophys Acta.Jan 2016 PMID: 26806157
  9. Arango-Lievano M, Sensoy O, Borie A, Corbani M, Guillon G, Sokoloff P, Weinstein H, Jeanneteau F. A GIPC1-Palmitate Switch Modulates Dopamine Drd3 Receptor Trafficking and Signaling Mol Cell BiolJan 2016 PMID: 26787837
  10. Khelashvili G, Stanley N, Sahai MA, Medina J, LeVine MV, Shi L, De Fabritiis G, Weinstein H. Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2‐Regulated Dynamics of the N‐Terminus ACS Chem NeurosciNov 2015 PMID: 26255829
  11. Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U. Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter J Biol ChemOct 2015 PMID: 26363074
  12. Khelashvili G, Weinstein H. Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops Biochim Biophys Acta.Sep 2015 PMID: 25847498
  13. Karlsen ML, Thorsen TS, Johner N, Ammendrup-Johnsen I, Erlendsson S, Tian X, Simonsen JB, Høiberg-Nielsen R, Christensen NM, Khelashvili G, Streicher W, Teilum K, Vestergaard B, Weinstein H, Gether U, Arleth L, Madsen KL. Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering StructureJul 2015 PMID: 26073603
  14. Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L. Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters J Biol ChemMay 2015 PMID: 25869126
  15. LeVine MV, Weinstein H. AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems EntropyMay 2015 PMID: 26594108
  16. Khelashvili G, Doktorova M, Sahai MA, Johner N, Shi L, Weinstein H. Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2-containing membranes ProteinsMay 2015 PMID: 25739722
  17. Sensoy O, Weinstein H. A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1–PDZ-domain Biochim Biophys Acta.Apr 2015 PMID: 25592838
  18. Akyuz N, Georgieva ER, Zhou Z, Stolzenberg S, Cuendet MA, Khelashvili G, Altman RB, Terry DS, Freed JH, Weinstein H, Boudker O, Blanchard SC. Transport domain unlocking sets the uptake rate of an aspartate transporter NatureFeb 2015 PMID: 25652997
  19. Perez-Aguilar JM, Shan J, LeVine MV, Khelashvili G, Weinstein H. A Functional Selectivity Mechanism at the Serotonin-2A GPCR Involves Ligand-Dependent Conformations of Intracellular Loop 2 J Am Chem SocNov 2014 PMID: 25314362
  20. Handschuh K, Feenstra J, Koss M, Ferretti E, Risolino M, Zewdu R, Sahai MA, Bénazet JD, Peng XP, Depew MJ, Quintana L, Sharpe J, Wang B, Alcorn H, Rivi R, Butcher S, Manak JR, Vaccari T, Weinstein H, Anderson KV, Lacy E, Selleri L. ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling. Cell RepOct 2014 PMID: 25373905
  21. Borre L, Andreassen TF, Shi L, Weinstein H, Gether U. The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride J Biol ChemSep 2014 PMID: 25063810
  22. Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, Law I, Pinborg LH, Sitte HH, Loland C, Shi L, Weinstein H, Galli A, Hjermind LE, Møller LB, Gether U. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD J Clin InvestJul 2014 PMID: 24911152
  23. Dehnes Y, Shan J, Beuming T, Shi L, Weinstein H, Javitch J. Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry InternationalJul 2014 PMID: 24576496
  24. Hamilton PJ, Belovich AN, Khelashvili G, Saunders C, Erreger K, Javitch JA, Sitte HH, Weinstein H, Matthies HJ, Galli A. PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein Nat Chem BiolJun 2014 PMID: 24880859
  25. Mondal S, Khelashvili G, Weinstein H. Not Just an Oil Slick: How the Energetics of Protein-Membrane Interactions Impacts the Function and Organization of Transmembrane Proteins Biophys JJun 2014 PMID: 24896109
  26. Kazmier K, Sharma S, Quick M, Islam SM, Roux B, Weinstein H, Javitch J, McHaourab H. Conformational dynamics of ligand-dependent alternating access in LeuT Nat Struct Mol BiolMay 2014 PMID: 24747939
  27. LeVine M, Weinstein H. NbIT - A New Information Theory-Based Analysis of Allosteric Mechanisms Reveals Residues that Underlie Function in the Leucine Transporter LeuT PLoS Comp BiolMay 2014 PMID: 24785005
  28. LeVine M,Perez-Aguilar JM,Weinstein H. N-body Information Theory (NbIT) Analysis of Rigid- Body Dynamics in Intracellular Loop 2 of the 5-HT2A Receptor Proceedings IWBBIO Apr 2014
  29. Johner N, Mondal S, Morra G, Caffrey M,Weinstein H, and Khelashvil G. Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization. J Am Chem SocFeb 2014 PMID: 24494670
  30. Mondal S, Khelashvili G, Johner N, and Weinstein H. How the Dynamic Properties and Functional Mechanisms of GPCRs Are Modulated by Their Coupling to the Membrane Environment Adv Exp Med BiolJan 2014 PMID: 24158801
  31. Mondal S, Johnston J, Wang H, Khelashvili G, Filizola M, Weinstein H. Membrane Driven Spatial Organization of GPCRs Nat Sci RepOct 2013 PMID: 24105260
  32. Khelashvili G, LeVine M, Shi L, Quick M, Javitch J, Weinstein H. The Membrane Protein LeuT in Micellar Systems: Aggregation Dynamics and Detergent Binding to the S2 Site J Am Chem SocJun 2013 PMID: 23980525
  33. Kantcheva AK, Quick M, Shi L, Winther AM, Stolzenberg S, Weinstein H, Javitch JA, and Nissen P. Chloride binding site of neurotransmitter sodium symporters PNASMay 2013 PMID: 23641004
  34. Mondal S, Khelashvili G, Shi L, Weinstein H. The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT Chem Phys LipApr 2013 PMID: 23376428
  35. Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ.. Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter J Biol ChemNov 2012 PMID: 23007398
  36. Khelashvili G, Albornoz PB, Johner N, Mondal S, Caffrey M, Weinstein H. Why GPCRs behave differently in cubic and lamellar lipidic mesophases J Am Chem SocSep 2012 PMID: 22931253
  37. Chunfeng Zhao, Sebastian Stolzenberg, Luis Gracia, Harel Weinstein, Sergei Noskov, and Lei Shi. Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT Biophys JSep 2012 PMID: 23009837
  38. Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S.. In support of the BMRB Nat Struct Mol BiolSep 2012 PMID: 22955930
  39. Khelashvili G, Galli A, Weinstein H. Phosphatidylinositol 4,5-Biphosphate (PIP(2)) Lipids Regulate the Phosphorylation of Syntaxin N-Terminus by Modulating Both Its Position and Local Structure BiochemSep 2012 PMID: 22950482
  40. Stolzenberg S, Khelashvili G, Weinstein H. Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh J Phys Chem BMay 2012 PMID: 22494242
  41. Shan J, Khelashvili G, Mondal S, Mehler EL, Weinstein H. Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT(2A) Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties PLoS Comp BiolApr 2012 PMID: 22532793
  42. Quick M, Shi L, Zehnpfennig B, Weinstein H, Javitch JA. Experimental conditions can obscure the second high-affinity site in LeuT Nat Struct Mol BiolJan 2012 PMID: 22245968
  43. Mondal S, Weinstein H, and Khelashvili G. Interactions of the Cell Membrane with Integral Proteins Comprehensive Biophysics, Vol. 9Jan 2012
  44. Weinstein H, Scarlata S. The correlation between multidomain enzymes and multiple activation mechanisms--the case of phospholipase Cβ and its membrane interactions Biochim Biophys Acta.Dec 2011 PMID: 21906583
  45. Mondal S, Khelashvili G, Shan J, Andersen OS, Weinstein H. Quantitative modeling of membrane deformations by multihelical membrane proteins: application to G-protein coupled receptors Biophys JNov 2011 PMID: 22067146
  46. Han DS, Golebiewska U, Stolzenberg S, Scarlata SF, Weinstein H. A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits Mol PharmacolSep 2011 PMID: 21693623
  47. Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homolog NatureJun 2011 PMID: 21516104
  48. He Y, Liwo A, Weinstein H, Scheraga HA. PDZ Binding to the BAR Domain of PICK1 is Elucidated by Coarse-grained Molecular Dynamics J Mol BiolJan 2011 PMID: 21050858
  49. Shan J, Javitch JA, Shi L, Weinstein H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter PLoS OneJan 2011 PMID: 21298009
  50. Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. The binding sites for benztropines and dopamine in the dopamine transporter overlap NeuropharmJan 2011 PMID: 20816875
  51. Shi L, Weinstein H. Conformational Rearrangements to the Intracellular Open States of the LeuT and ApcT Transporters Are Modulated by Common Mechanisms Biophys JDec 2010 PMID: 21156121
  52. Shan J, Weinstein H, Mehler EL. Probing the structural determinants for the function of intracellular loop 2 in structurally cognate g-protein-coupled receptors BiochemDec 2010 PMID: 21062002
  53. Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1 Org Biomol ChemOct 2010 PMID: 20668766
  54. Khelashvili G, Mondal S, Andersen OS, Weinstein H. Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors J Phys Chem BSep 2010 PMID: 20804205
  55. Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS. Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters Nat Struct Mol BiolJul 2010 PMID: 20562855
  56. Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA. Single-molecule dynamics of gating in a neurotransmitter transporter homologue NatureMay 2010 PMID: 20463731
  57. Zeynep H. Gümüş, Fernando Siso-Nadal, Ada Gjyrezi, Paul McDonagh, Iya Khalil, Paraskevi Giannakakou and Harel Weinstein. Quantification and analysis of combination drug synergy in high-throughput transcriptome studies IEEE Conf. Bioinf. Bioeng.Feb 2010
  58. Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, Rønn LC, Gether U. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD PNASJan 2010 PMID: 20018661
  59. Zhao Y, Quick M, Shi L, Mehler EL, Weinstein H, Javitch JA. Substrate-dependent proton antiport in neurotransmitter:sodium symporters Nat Chem BiolDec 2009 PMID: 20081826
  60. Khelashvili G, Harries D, Weinstein H. Modeling Membrane Deformations and Lipid Demixing upon Protein-Membrane Interaction: The BAR Dimer Adsorption Biophys JSep 2009 PMID: 19751667
  61. Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation Nat Chem BiolAug 2009 PMID: 19648932
  62. Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA. Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation PNASApr 2009 PMID: 19307590
  63. Guptaroy B, Zhang M, Bowton E, Binda F, Shi L, Weinstein H, Galli A, Javitch JA, Neubig RR, Gnegy ME. A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation Mol PharmacolMar 2009 PMID: 19098122
  64. Khelashvili G, Grossfield A, Feller SE, Pitman MC, Weinstein H. Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations ProteinsDec 2008 PMID: 19173312
  65. Madsen KL, Eriksen J, Milan-Lobo L, Han DS, Niv MY, Ammendrup-Johnsen I, Henriksen U, Bhatia VK, Stamou D, Sitte HH, McMahon HT, Weinstein H, Gether U. Membrane localization is critical for activation of the PICK1 BAR domain TrafficAug 2008 PMID: 18466293
  66. Chang CW, Poteet E, Schetz JA, Gümüş ZH, Weinstein H. Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: Measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation NeuropharmAug 2008 PMID: 18762202
  67. Han DS, Wang SX, Weinstein H. Active State-like Conformational Elements in the beta2-AR and a Photoactivated Intermediate of Rhodopsin Identified by Dynamic Properties of GPCRs BiochemJul 2008 PMID: 18558776
  68. Gümüş ZH, Du B, Kacker A, Boyle JO, Bocker JM, Mukherjee P, Subbaramaiah K, Dannenberg AJ, Weinstein H. Effects of Tobacco Smoke on Gene Expression and Cellular Pathways in a Cellular Model of Oral Leukoplakia Cancer Prev ResJul 2008 PMID: 19138943
  69. Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. The binding sites for cocaine and dopamine in the dopamine transporter overlap Nat NeurosciJul 2008 PMID: 18568020
  70. Shi L, Quick M, Zhao Y, Weinstein H, Javitch JA. The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site Mol CellJun 2008 PMID: 18570870
  71. Kniazeff J, Shi L, Loland CJ, Javitch JA, Weinstein H, Gether U. An intracellular interaction network regulates conformational transitions in the dopamine transporter J Biol ChemJun 2008 PMID: 18426798
  72. Taylor MS, Fung HK, Rajgaria R, Filizola M, Weinstein H, Floudas CA. Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework Biophys JApr 2008 PMID: 18178645
  73. Peter Májek, Ron Elber, and Harel Weinstein. Pathways of Conformational Transitions in Proteins Coarse-Graining of Condensed Phase Biomolecuar SystemsApr 2008
  74. Khelashvili G, Weinstein H, Harries D. Protein Diffusion on Charged Membranes: A Dynamic Mean-Field Model Describes Time Evolution and Lipid Reorganization Biophys JApr 2008 PMID: 18065451
  75. Niv MY, Skrabanek L, Roberts RJ, Scheraga HA, Weinstein H. Identification of GATC- and CCGGrecognizing Type II REases and their putative specificity-determining positions using Scan2S—a novel motif scan algorithm with optional secondary structure constraints ProteinsOct 2007 PMID: 17972284
  76. Sun J, Weinstein H. Toward realistic modeling of dynamic processes in cell signaling: Quantification of macromolecular crowding effects J Chem PhysOct 2007 PMID: 17949221
  77. Niv MY, Ripoll DR, Vila JA, Liwo A, Vanamee ES, Aggarwal AK, Weinstein H, Scheraga HA. Topology of Type II REases revisited; structural classes and the common conserved core NARMar 2007 PMID: 17369272
  78. Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology J Pharmacol Exp TherJan 2007 PMID: 16803859
  79. Beuming T, Shi L, Javitch JA, Weinstein H. A Comprehensive Structure-Based Alignment of Prokaryotic and Eukaryotic Neurotransmitter/Na+ Symporters (NSS) Aids in the Use of the LeuT Structure to Probe NSS Structure and Function Mol PharmacolNov 2006 PMID: 16880288
  80. Niv MY, Skrabanek L, Filizola M, Weinstein H. Modeling activated states of GPCRs: the rhodopsin template J Comput Aided Mol DesNov 2006 PMID: 17103019
  81. Basdevant N, Weinstein H, Ceruso M. Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study J Am Chem SocOct 2006 PMID: 17002371
  82. Quick M, Yano H, Goldberg NR, Duan L, Beuming T, Shi L, Weinstein H, Javitch JA. State-dependent Conformations of the Translocation Pathway in the Tyrosine Transporter Tyt1, a Novel Neurotransmitter:Sodium Symporter from Fusobacterium nucleatum J Biol ChemSep 2006 PMID: 16798738
  83. Filizola M, Wang SX, Weinstein H. Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer J Comput Aided Mol DesJul 2006 PMID: 17089205
  84. Mehler EL, Hassan SA, Kortagere S, Weinstein H. Ab Initio Computational Modeling of Loops in G-Protein- Coupled Receptors: Lessons from the Crystal Structure of Rhodopsin ProteinsMay 2006 PMID: 16729264
  85. Weinstein H. Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors AAPS JJan 2006 PMID: 16594640
  86. Sen N, Shi L, Beuming T, Weinstein H, Javitch JA. A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding NeuropharmNov 2005 PMID: 16216288
  87. Guo W, Shi L, Filizola M, Weinstein H, Javitch JA. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation PNASNov 2005 PMID: 16301531
  88. Niv MY, Weinstein H. A flexible docking procedure for the exploration of peptide binding selectivity to known structures and homology models of PDZ domains J Am Chem SocOct 2005 PMID: 16201829
  89. Carter M, Chen X, Slowinska B, Minnerath S, Glickstein S, Shi L, Campagne F, Weinstein H, Ross ME. Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6 PNASSep 2005 PMID: 16126904
  90. Filizola M, Weinstein H. The structure and dynamics of GPCR oligomers: a new focus in models of cell-signaling mechanisms and drug design Curr Opin Drug Discov DevelSep 2005 PMID: 16159019
  91. Filizola M, Weinstein H. The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics FEBS JJun 2005 PMID: 15955053
  92. Madsen KL, Beuming T, Niv MY, Chang CW, Dev KK, Weinstein H, Gether U. Molecular Determinants for the Complex Binding Specificity of the PDZ Domain in PICK1 J Biol ChemMay 2005 PMID: 15774468
  93. Beuming T, Weinstein H. Modeling membrane proteins based on low-resolution electron microscopy maps: a template for the TM domains of the oxalate transporter OxlT Protein Eng Des SelApr 2005 PMID: 15820982
  94. Kortagere S, Gmeiner P, Weinstein H, Schetz JA. Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain Mol PharmacolDec 2004 PMID: 15448188
  95. Beuming T, Skrabanek L, Niv MY, Mukherjee P, Weinstein H. PDZBase: a protein–protein interaction database for PDZ-domains BioinfOct 2004 PMID: 15513994
  96. Beuming T, Weinstein H. A knowledge-based scale for the analysis and prediction of buried and exposed faces of transmembrane domain proteins BioinfAug 2004 PMID: 14988128
  97. Campagne F, Neves S, Chang CW, Skrabanek L, Ram PT, Iyengar R, Weinstein H. Quantitative Information Management for the Biochemical Computation of Cellular Networks JCBAug 2004 PMID: 15340175
  98. Ramasubbu Sankararamakrishnan. Surface Tension Parameterization in Molecular Dynamics Simulations of a Phospholipid Membrane: Calibration and Effects J Phys Chem BJul 2004
  99. Filizola M, Hassan SA, Artoni A, Coller BS, Weinstein H. Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3 J Biol ChemJun 2004 PMID: 15056669
  100. Ceruso MA, Periole X, Weinstein H. Molecular dynamics simulations of transducin: interdomain and front to back communication in activation and nucleotide exchange J Mol BiolApr 2004 PMID: 15081806
  101. Goldberg NR, Beuming T, Soyer OS, Goldstein RA, Weinstein H, Javitch JA. Probing conformational changes in neurotransmitter transporters: a structural context Eur J PharmacolOct 2003 PMID: 14612133
  102. Campagne F, Bettler E, Vriend G, Weinstein H. Batch mode generation of residue-based diagrams of proteins BioinfSep 2003 PMID: 14512361
  103. Visiers I, Weinstein H, Rudnick G, Stephan MM. A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P BiochemJun 2003 PMID: 12779333
  104. Sun J, Viadiu H, Aggarwal AK, Weinstein H. Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex Biophys JMay 2003 PMID: 12719261
  105. Hassan SA, Mehler EL, Zhang D, Weinstein H. Molecular dynamics simulations of peptides and proteins with a continuum electrostatic model based on screened Coulomb potentials ProteinsApr 2003 PMID: 12596268
  106. Skrabanek L, Campagne F, Weinstein H. Building protein diagrams on the web with the residue-based diagram editor RbDe NARApr 2003 PMID: 12824436
  107. Ebersole BJ, Visiers I, Weinstein H, Sealfon SC. Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy Mol PharmacolJan 2003 PMID: 12488534

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