Weill Medical College  of Cornell University
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Lawrence Palmer

Original Articles:

1. Ling, G.N. and L.G. Palmer. Studies on ion permeability IV: The mechanisms of ouabain action on the Na+-ion efflux in frog muscles. Physiol. Chem. Phys. 4: 517-522 (1972)

2. Palmer, L.G. and M.M. Civan. Intracellular distribution of free potassium in Chironomus salivary glands. Science 188: 1321-1322 (1975)

3. Palmer, L.G. and J. Gulati. K+ accumulation in muscle: A test of the binding hypothesis. Science 194: 521-523 (1976)

4. Palmer, L.G. and M.M. Civan. Distribution of Na+, K+ and Cl- between nucleus and cytoplasm in Chironomus salivary glands. J. Membrane Biol. 33: 41-61 (1977)

5. Palmer, L.G., T.J. Century and M.M. Civan. Activity coefficients of intracellular Na+ and K+  during development of frog oocytes. J. Membrane Biol. 40: 25-38 (1978)

6. Palmer, L.G., I.S. Edelman and B. Lindemann. Current-voltage analysis of apical sodium transport in toad urinary bladder: Effects of inhibitors of transport and metabolism. J. Membrane Biol. 57: 59-71 (1980)

7. Li, J. H.-Y., L.G. Palmer, I.S. Edelman and B. Lindemann. The role of sodium-channel density in the natriferic response of the toad urinary bladder to an antidiuretic hormone. J. Membrane Biol. 64: 77-89 (1982)

8. Palmer, L.G., J. H.-Y. Li, B. Lindemann and I.S. Edelman. Aldosterone control of the density of sodium channels in the toad urinary bladder. J. Membrane Biol. 64: 91-102   (1982)

9. Palmer, L.G. Ion selectivity of the apical membrane Na channel in the toad urinary bladder. J. Membrane Biol. 67: 91-98 (1982)

10. Palmer, L.G. Na transport and flux ration through apical Na channels in toad bladder. Nature 297: 688-690 (1982)

11. Palmer, L.G and M. Lorenzen. Antidiuretic hormone-dependent membrane capacitance and  water permeability in the toad urinary bladder. American J. Physiol. 244: F195-F204 (1983)

12. Nelson, D.J., J.M. Tang and L.G. Palmer. Single channel recordings of apical membrane chloride conductance in A6 epithelial cells. J. Membrane Biol. 80: 81-89 (1984).

13. Palmer, L.G. Voltage-dependent block by monovalent cations of the apical Na channel in the toad urinary bladder. J. Membrane Biol. 80: 153-165 (1984)

14. Palmer, L.G. and N. Speez. Modulation of ADH-dependent capacitance changes and water flow in toad urinary bladder. American J. Physiol. 246: F501-F508 (1984)

15. Palmer, L.G. Modulation of apical Na permeability of the toad urinary bladder by intracellular Na, Ca and H. J. Membrane Biol. 83: 57-69 (1985)

16. Palmer, L.G. Interactions of amiloride and other blocking cations with the apical Na channel in the toad urinary bladder. J. Membrane Biol. 87: 191-199 (1985)

17. Palmer, L.G. and N. Speez. Stimulation of apical Na permeability and basolateral Na pump of toad urinary bladder by aldosterone. Am. J. Physiol. 250: F273-F281 (1986)

18. Palmer, L.G. and G. Frindt. Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule. Proc. Natl. Acad. Sci. (USA) 83: 2767-2770 (1986)

19. Palmer, L.G. Apical membrane K conductance in the toad urinary bladder. J. Membrane Biol. 92 : 217-226 (1986)

20. Frindt, G. and L.G. Palmer. Ca-activated K channels in the apical membrane of the mammalian cortical collecting tubule and their role in K secretion. Am. J. Physiol. 252:   F458-F476 (1987)

21. Palmer, L.G. and G. Frindt. Effects of cell Ca and pH on Na channels from rat cortical collecting tubules. Am. J. Physiol. 253: F333-F339 (1987)

22. Sackin, H. and L.G. Palmer. Basolateral potassium channels in renal proximal tubule. Am. J. Physiology 253: F476-F487 (1987)

23. Davies, R.J., W.F. Weidema, G.I. Sandle, L.G. Palmer, E.E. Deschner and J.J. DeCosse. Sodium transport in a mouse model of colonic carcinogenesis. Cancer Res. 47: 4646-4650   (1987)

24. Palmer, L.G. and G. Frindt. Conductance and gating of epithelial Na channels in rat cortical collecting tubule: Effects of luminal Na and Li. J. Gen. Physiol. 92: 121-138 (1988)

25. Das, S and L.G. Palmer. Extracellular Ca2+ controls outward rectification by apical cation channels in toad urinary bladder: Patch clamp and whole-bladder studies. J. Membrane Biol. 107: 157-168 (1989)

26. Silver, R.B. and L.G. Palmer. 8-Br-cAMP-induced capacitance and transport of H2O and Na in skin and urinary bladder of urodele amphibians. Am. J. Physiol. 256: C1145-C1152 (1989)

27. Palmer, L.G. and O.S. Andersen. Interactions of amiloride and small monovalent cations with the epithelial sodium channel: Inferences about the nature of the channel pore. Biophys. J.  55: 779-787 (1989)

28. Frindt, G. and L.G. Palmer. Low-conductance K channel in apical membrane of rat cortical collecting tubule. Am. J. Physiol. 256: F143-F151 (1989)

29. Frindt, G., H. Sackin and L.G. Palmer. Whole-cell currents in rat cortical collecting tubule:   Low sodium diet increases amiloride-sensitive conductance. Am. J. Physiol. 258: F562-F567 (1990)

30. Palmer, L.G., I. Corthésy-Theulaz, H.-P. Gaeggler, J.-P. Kraehenbuhl and B. Rossier. Expression of epithelial Na channels in Xenopus oocytes. J. Gen. Physiol. 96: 23-46 (1990)

31. Strieter, J., J.L. Stephenson, L.G. Palmer and A.M. Weinstein. Volume-activated chloride permeability can mediate cell volume regulation in a mathematical model of a tight epithelium. J. Gen. Physiol. 96: 319-344 (1990)

32. Das, S., M. Garepapaghi, and L.G. Palmer. Stimulation by cyclic GMP of apical Na channels and cation channels in toad urinary bladder. Am. J. Physiol. 260:C234-C241 (1991)

33. Pácha, J., G. Frindt, H. Sackin and L.G. Palmer. Apical maxi K channels in intercalated cells of CCT. Am. J. Physiol. 261:F696-F705 (1991)

34. Silver, R.B., G. Frindt and L.G. Palmer. Regulation of principal cell pH by Na/H exchange in rabbit cortical collecting tubule. J. Membrane Biol. 125:13-24 (1992)

35. Silver, R.B., G. Frindt, E.E. Windhager and L.G. Palmer. Feedback inhibition of Na channels in rat CCT. I. Effects of inhibition of the Na pump. Am. J. Physiol. 264: F557-564 (1993)

36. Frindt, G., R.B. Silver, E.E. Windhager and L.G. Palmer. Feedback inhibition of Na channels in rat CCT. II. Effects of inhibition of Na entry. Am. J. Physiol. 264: F565-F574        (1993)

37. Pácha, J., G. Frindt, L. Antonian, R.B. Silver and L.G. Palmer. Regulation of Na channels of the rat cortical collecting tubule by aldosterone. J. Gen. Physiol. 102:25-42 (1993)

38. Palmer, L.G., L. Antonian and G. Frindt. Regulation of the Na-K pump of the rat cortical collecting tubule by aldosterone. J. Gen. Physiol. 102:43-57 (1993)

39. Zhou, H., S. Tate, and L.G. Palmer. Primary structure and functional properties of an epithelial K channel. Am. J. Physiol. 266:C809-C824 (1994)

40. Palmer, L.G., L. Antonian and G. Frindt. Regulation of apical K and Na channels and Na/K            pumps in rat cortical collecting tubule by dietary K. J. Gen. Physiol. 104:693-710 (1994)

41. Chepilko, S., H. Zhou, H. Sackin and L.G. Palmer. Permeation and gating properties of a cloned renal K channel. Am. J. Physiol. 268:C389-C401 (1995)

42. Frindt, G., R.B. Silver, E.E. Windhager and L.G. Palmer. Feedback regulation of Na channels in rat CCT III. Response to cAMP. Am. J. Physiol. 268:F480-F489 (1995)

43. Palmer, L.G. and Frindt, G. Gating of Na channels in the rat cortical collecting tubule: Effects of voltage and membrane stretch. J. Gen. Physiol. 107:35-45 (1996)

44. Frindt, G., L.G. Palmer and E.E. Windhager. Feedback regulation of Na channels in rat CCT IV. Mediation by activation of PKC Am. J. Physiol. 270:F371-F376 (1996)

45. Satlin, L. and L.G. Palmer. Apical Na+ conductance in maturing rabbit principal cell. Am. J. Physiol. 270: F391-F397 (1996)

46. Frindt, G. and L.G. Palmer. Regulation of Na channels in the rat cortical collecting tubule: effects of cAMP and methyl donors. Am. J. Physiol. 271:F1086-F1092 (1996)

47. Zhou, H., S. Chepilko, W. Schütt, H. Choe, L.G. Palmer. and H.S. Sackin. Mutations in the pore region of ROMK enhance Ba block. Am. J. Physiol. 271:C1949-C1956 (1996)

48. Satlin, L.M. and L.G. Palmer. Apical K conductance in maturing rabbit principal cell. Am. J. Physiol. 272:F397-F404 (1997)

49. Choe, H., H. Zhou, L.G. Palmer and H. Sackin. A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance and gating. Am. J. Physiol. 273: F516-F529 (1997)

50. Palmer, L.G., Choe, H. and G. Frindt. Is the secretory K channel in the rat CCT ROMK? Am. J. Physiol. 273:F404-F410 (1997)

51. Mennitt, P.A., Wade, J.B., Ecelbarger, C.A., Palmer, L.G. and Frindt, G. Localization of ROMK channels in the rat kidney. J. Am. Soc. Nephrol. 8: 1823-1830 (1997)

52. Frindt, G., Zhou, H., Sackin, H. and Palmer, L.G. Dissociation of K channel density and ROMK mRNA in rat cortical collecting tubule during K adaptation. Am. J. Physiol. 274:F525-F531 (1998)

53. Palmer, L.G., Sackin, H. and Frindt, G. Regulation of Na+ channels by luminal Na+ in rat cortical collecting tubule. J. Physiol. (London) 509:151-162 (1998)

54. Choe, H., Sackin, H. and Palmer, L.G. Permeation and gating of an inwardly rectifying potassium channel: Evidence for a variable energy well. J. Gen. Physiol. 112: 433-446             (1998)

55. Choe, H., Palmer, L.G. and Sackin, H. Structural determinants of gating in inward-rectifier K + channels. Biophys. J. 76:1988-2003 (1999)

56. Palmer, L.G. and Frindt, G. Regulation of apical K channels in the rat cortical collecting tubule during changes in dietary K intake. Am. J. Physiol. 277:F805-F812 (1999)

57. Choe, H., Sackin, H. and Palmer, L.G. Permeation properties of inward-rectifier potassium channels and their molecular determinants. J. Gen. Physiol. 115:391-2000 (2000)

58. Mennitt, P.A., Frindt, G., Silver, R.B. and Palmer, L.G. Potassium restriction downregulates ROMK expression in rat kidney. Am. J. Physiol. 278:F916-F924 (2000)

59. Frindt, G. and Palmer, L.G. Activation of epithelial Na channels during short-term Na deprivation. Am. J. Physiol. 280:F112-118 (2001)

60. Sackin, H., Syn, S., Palmer, L.G., Choe, H. and Walters, D.E. Regulation of ROMK by extracellular cations. Biophys. J. 80:683-697 (2001)

61. Rajasekaran, S., Palmer, L.G., Quan, K., Harper, J.F., Ball, W.J. Jr., Bander, N.H., Soler, A.P. and Rajasekaran, A.K. Na,K-ATPase b-subunit is required for epithelial polarization, suppression of invasion and cell motility. Mol. Biol. Cell 12:279-295 (2001)

62. Choe, H., Sackin, H. and Palmer, L.G. Gating properties of inward-rectifier potassium channels: Effects of permeant ions. J. Membrane Biol. 184:81-89 (2001)

63. Frindt, G., McNair, T., Dahlmann, A., Jacobs-Palmer, E. and Palmer, L.G. Epithelial Na channels and the short-term renal response to salt deprivation. Am. J. Physiol. 283:F717-F726 (2002)

64. Sackin, H., Vasilyev, A., Palmer, L.G. and Krambis, M. Permeant cations and blockers modulate pH gating of ROMK channels. Biophys. J. 84: 910-921 (2003)

65. Dahlmann, A., Pradervand, S., Hummler, E., Rossier, B.C., Frindt, G. and Palmer, L.G. Mineralocorticoid regulation of epithelial Na+ channels in a mouse model of Liddle's Syndrome. Am. J. Physiol. 285:F310-318 (2003)

66. Rubera, I., Loffing, J., Palmer, L.G., Frindt, G., Fowler-Jaeger, N., Sauter, D., Carroll, T., McMahon, A., Hummler, E. and Rossier, B.C. J. Clin. Invest. 112:554-565 (2003)

67. Dahlmann A, Li M, Gao Z, McGarrigle D, Sackin H, Palmer LG. Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling. J Gen Physiol. 123:441-54 (2004).

68. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E, Rossier BC. Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest. 112:554-65 (2003).

69. Sackin H, Palmer LG, Krambis M. Potassium-dependent slow inactivation of Kir1.1 (ROMK) channels. Biophys J. 86:2145-55 (2004).

70. Frindt G, Palmer LG. Na channels in the rat connecting tubule. Am J Physiol Renal Physiol. 2004 [in press].

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Reviews, Invited Articles and Book Chapters

1. Palmer, L.G. and I.S. Edelman. Control of apical sodium permeability in the toad urinary bladder by aldosterone. Ann. N.Y. Acad. Sci. 372: 1-14 (1981)

2.Palmer, L.G. Studies of hormonal control of epithelial transport using fluctuation analysis. In:  The Kidney During Development. A. Spitzer, ed.pp. 61-65. Masson Publishing, USA (1982)

3. Taylor, A. and L.G. Palmer. Hormonal regulation of sodium chloride and water transport in epithelia. In: Biological Regulation and Development. vol 3A, R.F. Goldberger and K. Yamamoto, eds. pp. 253-298. Plenum Publishing, NY (1982)

4. Palmer, L.G. Use of potassium depolarization to study apical transport properties in epithelia. Current Topics in Membranes and Transport 20: 105-121 (1984)

5. Palmer, L.G. and N. Speez. Physiological mechanisms underlying the stimulation of Na transport in the toad urinary bladder by aldosterone. In: Transport Processes, Iono- and Osmoregulation. R. Gilles and M. Gilles- Baillien, eds., pp. 108-117. Springer-Verlag, Berlin-Heidelberg (1985)

6. Palmer, L.G. The epithelial Na channel. In: New Insights into Cell and Membrane Transport Processes. G. Poste and S.T. Crooke, eds. pp. 327-344. Plenum Press, NY (1986)

7. Palmer, L.G. and G. Frindt. Epithelial Na channels: Characterization using the patch-clamp technique. Fed.Proc. 45: 2708-2712 (1986)

8. Palmer, L.G. Patch-clamp technique in renal physiology (Editorial Review). Am. J. Physiol. 250: F379-F385 (1986)

9. Palmer, L.G. Selectivity of epithelial Na channels (Topical Review). J. Membrane Biol. 96: 97-106 (1987)

10. Palmer, L.G. Regulation of NaCl transport in tight epithelia. In: Advances in Environmental and Comprative Physiology. NaCl Transporting Epithelia in Animals. R. Greger, ed. pp. 292-309, Springer-Verlag, Heidelberg (1988)

11. Palmer, L.G. and H. Sackin. Regulation of renal ion channels. FASEB J. 2: 3061-3065 (1988)

12. Palmer, L.G. The regulation of cell potassium. In: The Regulation of Potassium Balance, G. Giebisch and D. Seldin, eds. pp. 89-119, Raven Press, NY (1989)

13. Palmer, L.G., G. Frindt, R. Silver, and J. Strieter. Feedback regulation of epithelial Na channels. Current Topics in Membranes and Transport 34: 45-60 (1989)

14. Palmer, L.G. Epithelial Na channels: The nature of the conducting pore. Renal Physiol. and Biochem. 13: 51-58 (1990)

15. Palmer, L.G. The epithelial Na channel: Inferences about the nature of the conducting pore. Comments on Molecular and Cellular Biophysics 7: 259-283 (1991)

16. Palmer, L.G., J. Pácha and G. Frindt. Regulation of apical sodium channels in the rat cortical collecting tubule by aldosterone. in: Aldosterone: Fundamental Aspects. Eds. J.P. Bonvalet, N. Farman, M. Lombès and M.E. Rafestin-Oblin. Colloque INSERM/John Libby Eurotest vol. 215, pp. 285-293 (1991)

17. Palmer, L.G. Renal Ion channels. In: Handbook of Physiology: Renal Physiology. E.E. Windhager, ed. Oxford Press pp.715-738 (1992)

18. Palmer, L.G. and H. Sackin. Electrophysiological analysis of epithelial transport. In: The Kidney: Physiology and Pathophysiology. Second Edition. D. Seldin and G. Giebisch, eds. Raven Press pp. 361-406 (1992)

19. B. Rossier and L.G. Palmer. Mechanisms of aldosterone action on sodium and potassium transport. In: The Kidney: Physiology and Pathophysiology. Second Edition. D. Seldin and G. Giebisch, eds. Raven Press pp. 1373-1409 (1992)

20. Palmer, L.G. Epithelial Na channels: function and diversity. Annu. Rev. Physiol. 54: 51- 66 (1992)

21. Palmer, L.G. and G. Frindt. Regulation of apical membrane Na and K channels in rat renal collecting tubules by aldosterone. Seminars in Nephrology 12:37-43 (1992)

22. Palmer, L.G. Epithelial Na channels and their kin. News in Physiological Sciences 10:61-67 (1995)        

23. Palmer, L.G. and T. R. Kleyman. Potassium-sparing diuretics: Amiloride. Handbook of Experimental Pharmacology vol. 117: "Diuretics". R.F. Greger, H. Knauf and E. Mutschler, eds. (1995)

24. Palmer, L.G. Na transport by epithelia. In: The Molecular Biology of Membrane Transport Disorders, S.G. Schultz, ed. Plenum Press (1996)

25. Garty, H. and L.G. Palmer. The epithelial Na channel: Function, structure and regulation. Physiol. Rev. 77: 359-396 (1997)

26. Palmer, L.G. Potassium secretion and the regulation of distal nephron K channels. Am. J. Physiol. 274:F817-F833 (1999) – Brief review

27. Palmer, L.G. and G. Frindt. Aldosterone and potassium secretion by the cortical collecting duct. Kidney International 57:1324-1328 (2000)

28. Palmer, L.G. and Garty, H. Epithelial Na Channels . in: "The Kidney: Physiology and Pathophysiology" . 3rd Edition D. Seldin and G, Giebisch, eds. Lippincott-Raven (2000)

29. H. Sackin and Palmer, L.G. . Electrophysiological analysis of epithelial transport. In: The Kidney: Physiology and Pathophysiology. Third Edition. D. Seldin and G. Giebisch, eds. Lippincott-Raven (2000)

30. Palmer, L.G. (2001) Intracellular pH as a regulator of epithelial Na+ transport. J. Membrane Biol. 184: 305-311.

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