Weill Medical College  of Cornell University
Weill Medical College  of Cornell University Cornell University
Department of Physiology and Biophysics
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Harel Weinstein

A. Older peer reviewed publications (pre-2003)

A146. Mehler, E.L., Periole, X., Hassan, S.A., and Weinstein, H. – Key issues in the computational simulation of GPCR function: representation of loop domains. J Comp Assist Molec Design, 2002, 16:841-853. PubMed

A145. Filizola, M. and Weinstein, H. – Structural models for dimerization of G-protein coupled receptors: The opioid receptor homodimers. Biopolymers: (Peptide Science) 2002, 66:317-325 (Journal Cover Illustration). PubMed

A144. Huang, P., Visiers, I., Weinstein, H. and Liu-Chen, L-Y. – The local environment at the cytoplasmic end of TM6 of the m opioid receptor differs from those of rhodopsin and monoamine receptors: Introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivates the m opioid receptor and reduces the constitutive activity of its Thr6.34(279)K mutant. Biochemistry, 2002, 41:11972-11980. PubMed

A143. Filizola, M., Olmea, O. and Weinstein, H. – Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein Engng., 2002, 15:881-885. PubMed

A142. Prioleau, C.,Visiers, I., Ebersole, B.J., Weinstein, H. and Sealfon, S.C.– Conserved helix7 Tyrosine acts as a multistate conformational switch in the 5-HT2C receptor: Identification of a novel “locked-on” phenotype and double revertant mutations. J. Biol. Chem., 2002, 277:36577-36584. PubMed

A141. Ceruso, M. and Weinstein, H. – Structural mimicry of proline kinks: Tertiary packing interactions support local structural distortions. J. Mol. Biol., 2002, 318:1237-1249. PubMed

A140. Visiers, I., Ebersole, B.J., Dracheva, S., Ballesteros, J.A., Sealfon, S.C. and Weinstein, H. Structural Motifs as Functional Microdomains in G-Protein-Coupled Receptors: Energetic considerations in the mechanism of activation of the Serotonin 5HT2A receptor by disruption of the ionic lock of the arginine cage. Intl. J. Quantum Chem. 2002, 88:65-75.

A139. Sankararamakrishnan, R. and Weinstein, H. – Positioning and stabilization of Dynorphin peptides in membrane bilayers: The mechanistic role of aromatic and basic residues revealed from comparative MD simulations. J. Phys. Chem. B 2002, 106:209-218. Full Text

A138. Huang P, Li J, Chen C, Visiers I, Weinstein H, Liu-Chen LY. unctional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. Biochemistry 2001, 40:13501-9. PubMed

A137. Li, J., Huang, P., Chen, C., de Riel, J.K., Weinstein, H., and Liu-Chen, L-Y. Constitutive activation of the m opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. Biochemistry 2001, 40:12039-12050. PubMed

A136. Xu, W., Li, J., Chen, C., Huang, P., Weinstein, H., Javitch, J.A., Shi, L., de Rie, J.K., and Liu-Chen, L-Y. Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of m, d and k opioid receptors. Biochemistry 2001, 40:8018-8029. PuMed

A135. Max, M, Shanker, YG, Huang,L, Rong, M, Liu, Z, Campagne, F, Weinstein, H, Damak, S, Margolskee. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nature Genetics. 2001, 28:58-63. PubMed

A134. Visiers, I., Hassan, S.A. and Weinstein, H. Differences in conformational properties of the second intracellular loop (IL2) in 5HT(2C) receptors modified by RNA editing can account for G protein coupling efficiency. Protein Engng. 2001 14:409-414. Abstract        Full text        Reprint (PDF)

A133. Lebrun, A., Lavery, R., and Weinstein, H. - Modeling multi-component protein-DNA complexes: The role of bending and dimerization in the complex of p53 dimers with DNA. Protein Engng. 2001 14:233-243. Abstract        Full text        Reprint (PDF)

A132. Norregaard, L., Visiers, I., Loland, C., Ballesteros, J., Weinstein, H. and Gether, U. - Structural probing of the dopamine transporter by engineering of artificial Zn2+ binding sites. Biochemistry 2000, 39:15836-15846. PubMed

A131. Pastor, N., Weinstein, H., Jamison, E. And Brenowitz, M. - A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specific binding. J. Mol. Biol. 2000 -304:55-68. (Journal Cover Illustration) Abstract        Full text (with subscription)

A130. Sansom, M.S.P. and Weinstein, H. – Hinges, swivels and switches: The role of prolines in signalling via transmembrane alpha-helices. Trends. Pharmacol Sci. 2000, 21:445-451. (Cover Feature). PubMed

A129. Javitch, J.A., Shi, L., Simpson, M.M., Chiappa, V., Chen, J., Visiers, I., Weinstein, H. and Ballesteros, J.A. – The fourth transmembrane segment of the dopamine D2 receptor: Accessibility in the binding-site crevice and position in the transmembrane bundle. Biochemistry 2000, 39:12190-12199. PubMed

A128. Sankararamakrishnan, R., and Weinstein, H. Molecular Dynamics simulations predict a tilted orientation for the helical region of Dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers. Biophys. J. 2000, 79:2331-2344. (Journal Cover Illustration). Abstract        Full text (with subscription)

A127. Visiers, I., Braunheim, B.B. and Weinstein, H. – Prokink: A protocol for numerical evaluation of helix distortions by proline. Protein Engng. 2000, 13:603-606. Abstract        Full text        Reprint (PDF)

A126. Flanagan, C.A., Rodic, V., Konvicka, K.,Yuen, T., Chi, L., Rivier, J.E., Millar, R.P., Weinstein, H., and Sealfon, S. - Specific interactions of the Asp2.61(98) side chain of the GnRH receptor contribute differentially to ligand interaction. Biochemistry 2000, 39:8133-8141. PubMed

A125. Konvicka, K., Campagne, F., and Weinstein, H. – Interactive construction of residue-based diagrams of proteins: The RbDE web service. Protein Engng. 2000, 13:395-396. Abstract        Full text        Reprint (PDF)

A124. Pardo, L., Campillo, M., Bosch, D., Pastor, N., and Weinstein, H. - Binding mechanisms of TATA Box-binding proteins: DNA kinking is stabilized by specific hydrogen bonds. Biophys J., 2000, 78:1988-1996. Abstract        Full text (with subscription)

A123. Campagne, F. and Weinstein, H. - Schematic representation of residue-based protein context-dependent data: an application to transmembrane proteins. J. Mol. Graphics Model., 1999, 17:207-213. PubMed

A122. Flanagan, C.A., Zhou, W., Chi, L., Yuen, T., Rodic, V., Robertson, D., Johnson, M., Holland, P., Millar, R.P., Weinstein, H., Mitchell, R., and Sealfon, S. - The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation and coupling of the GnRH receptor. J. Biol. Chem. 1999, 274:28880-86. PubMed

A121. Sankararamakrishnan, R., Konvicka, K., Mehler, E.L., and Weinstein, H. - Solvation in simulated annealing and high temperature molecular dynamics of proteins: A restrained water droplet model. Intl. J. Quantum. Chem., 2000 , 77:174-186.

A120. Ri, Y., Ballesteros, J.A., Abrams, C.K., Oh, S., Verselis, V.K., Weinstein, H. and Bargiello, T.A. - The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions, Biophys J.,1999, 76:2887-98. Abstract        Full text (with subscription)

A119. Hou, W.-S., Bromme, D., Zhao, Y., Mehler, E.L., Dushey, C., Weinstein, H., Miranda, C.S., Fraga, C., Greig, F., Carey, J., Rimoin, D. L., Desnick, R.J., Gelb, B.D. - Cathepsin K: Characterization of novel mutations in the pro and mature polypeptide regions causing pychnodysostosis, J. Clin. Inv., 1999 , 103:731-738. PubMed

A118. Pastor, N., MacKerell Jr., A.D. and Weinstein, H. - TIT for TAT: The properties of inosine and adenosine in TATA box DNA, J. Biomol. Struct. Dyn., 1999 , 16:787-810. PubMed

A117. Duong, T-Ha, Mehler, E.L., and Weinstein, H. - Molecular dynamics simulation of membrane bilayers and the stabilization of transmembrane helix-7 of the 5-HT2A receptor. J. Comput. Phys., 1999 , 151:358-387.

A116. Xu, W., Ozdener, F., Li, J.G., Chen, C., de Riel, J.K., Weinstein, H. and Liu-Chen, L.-Y. - Functional role of the spatial proximity of Asp2.50(114) in TMH2 and Asn7.49(332) in TMH7 of the m opioid receptor. FEBS Letters 1999, 447:318-324. PubMed

A115. Pardo, L., Pastor, N., and Weinstein, H. - Selective binding of the TATA box-binding protein to the TATA box-containing promoter: Analysis of structural and energetic factors. Biophys. J. 1998, 75:2411-2421. Abstract        Full text (with subscription)

A114. Konvicka, K., Guarnieri, F., Ballesteros, J.A. and Weinstein, H. - A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an Asn-Pro/Asp-Pro motif. Biophys. J. 1998, 75:601-611. Abstract        Full text (with subscription)

A113. Carter, J., Gragerov, A., Konvicka, K., Elder, G., Weinstein, H., and Lazzarini, R.A. - Neurofilament assembly: Divergent characteristics of human and rodent NF-L subunits. J. Biol. Chem., 1998 , 273:5101-5108. PubMed

A112. Pardo, L., Pastor, N., and Weinstein, H. - Progressive DNA bending is made possible by gradual changes in the torsion angle of the glycosyl bond. Biophys J. 1998, 74:2191-98. Abstract        Full text (with subscription)

A111. Wriggers, W., Mehler, E.L., Pitici, F., Weinstein, H., and Schulten, K. - Structure and dynamics of calmodulin in solution. Biophys. J. 1998, 74:1622-1639. (Cover Illustration) Abstract        Full text (with subscription)

A110. Ballesteros, J.A., Kitanovic, S., Guarnieri, F., Davies, P., Fromme, B.J., Konvicka, K., Chi, L., Millar, R., Davidson, J.S., Weinstein, H., and Sealfon, S. - Functional microdomains in G protein-coupled receptors: The conserved arginine cage motif in the gonadotropin-releasing hormone receptor. J. Biol. Chem., 1998 , 273:10445-10453. PubMed

A109. Javitch, J.A., Ballesteros, J.A., Weinstein, H., and Chen, J. - An aromatic cluster of residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice. Biochemistry, 1998, 37:998-1006. PubMed

A108. Gether, U., Lin, S., Ghanouni, P. Ballesteros, J.A., Weinstein, H., and Kobilka, B. - Agonists induce conformational changes in transmembrane domains III and IV of the b2 adrenoreceptor. EMBO J. 1997, 16:6737-6747. PubMed

A107. Pastor, N., Pardo, L., and Weinstein, H. - Does TATA matter? A structural exploration of the selectivity determinants in its complexes with TBP. Biophys. J.1997, 73:640-52. Abstract

A106. Strahs, D., and Weinstein, H. - Comparative modeling and molecular dynamics studies of the d, k, and m opioid receptors. Protein Engng. 1997, 10:1019-1038. (Cover Illustration). Abstract        Full text        Reprint (PDF)

A105. Soirat, A.J.A., Wong, C.F., Osman, R. and Weinstein, H. - Brownian dynamics simulations of the reactions of hydrated electrons with components of DNAs and a DNA double helix. J. Comput. Chem. 1997, 18:888-901.

A104. Sealfon, C.S., Weinstein, H. and Millar, R.P.-Molecular mechanisms of ligand interaction with the Gonadotropin-releasing hormone receptor. Endocrine Rev. 1997 , 18:180-205.

A103. Chen, Y., Weng, G., Li, J., Hary, A., Pieroni, J., Dingus, J., Hildebrandt, J.D., Guarnieri, F., Weinstein, H., and Iyengar, R. - A surface on Gß involved in interactions with adenylyl cyclases. Proc. Natl. Acad. Sci. USA, 1997, 94:2711-2714. PubMed

dA102. Gether, U., Ballesteros, J.A., Seifert, R., Sanders-Bush, E., Weinstein, H., and Kobilka, B. Structural instability of a constitutively active G protein coupled receptor: Agonist-independent activation due to conformational flexibility. J. Biol Chem 1997, 272:2587-90. PubMed

A101. Pardo, L. and Weinstein, H. - On the Structure and Activity of Membrane Receptors: A Computational Simulation of Ligand-Triggered Activation in a Model 5-HT1A Receptor. Intl. J. Quantum Chem. 1997, 63:767-780.

A100. Weng, G., Li, J., Dingus, J., Hildebrandt, J.D., Weinstein, H., and Iyengar, R. - Gß subunit interacts with a peptide encoding region 956-982 of adenylyl cyclase 2 : Crosslinking of the peptide to free Gßg but not the heterotrimer. J. Biol. Chem. 1996, 271:26445-48. PubMed

A99. Fu, D., Ballesteros, J.A., Weinstein, H., Chen, J. and Javitch, J.A. - Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice. Biochemistry, 1996, 35:11278-11285. PubMed

A98. Almaula, N., Ebersole, B.J., Zhang, D., Weinstein, H. and Sealfon, S.C. - Mapping the binding site pocket of the serotonin 5-HT2A receptor: Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of LSD or Bufotenin. J. Biol. Chem. 1996, 271:14672-14675. PubMed

A97. Weinstein, H. and Mehler, E.L. - Structural change mechanisms in regulatory proteins Science, 1996, 271:1792-1793. PubMed

A96. Pardo, L., Battle, M., Dunach, M., and Weinstein, H. - Structure and activity of membrane receptors: Modeling and computational simulation of ligand recognition in a three-dimensional model of the 5-HT1A receptor. J. Biomed. Sci. 1996, 3:98-107.

A95. Almaula, N., Ebersole, B.J., Ballesteros, J.A., Weinstein, H. and Sealfon, S.C. - Contribution of a helix 5 locus to selectivity of hallucinogenic and non-hallucinogenic ligands for the human 5-HT2A and 5-HT2C receptors: Direct and indirect effects on ligand affinity mediated by the same locus. Mol. Pharmacol. 1996, 50:34-42. PubMed

A94. Guarnieri, F. and Weinstein, H. - Conformational memories and the exploration of biologically relevant peptide conformations: An illustration for the gonadotropin-releasing hormone. J. Amer. Chem. Soc. 1996, 118: 5580-5589.

A93. Zhou, W., Flanagan, C.A., Rodic, V., Chi, L. Weinstein, H., Maayani, S., Millar, R.P., and Sealfon, S.C. - A locus of the gonadotropin releasing hormone receptor which differentiates agonist and antagonist binding sites. J. Biol. Chem. 1995, 270:18853-18857. PubMed

A92. Sealfon, S.C., Chi, L., Ebersole, B.J., Rodic, V., Zhang, D., Ballesteros, J.A. and Weinstein, H. - Related contributions of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor. J. Biol. Chem. 1995, 270:16683-16688.

A91. Gulati, J., Akella, A.B, Su, H. Mehler, E.L. and Weinstein, H. - The functional role of Arg–11 in the N-terminal helix of skeletal troponin C: A combined mutagenesis and molecular dynamics investigation. Biochemistry 1995, 34:7378-7355. PubMed

A90. Pastor, N., and Weinstein, H. - Electrostatic analysis of DNA binding properties in Lysine-to-Leucine mutants of TATA-box binding proteins. Protein Engng. 1995, 8:543-549. Abstract

A89. Luo, X., Zhang, D. and Weinstein, H. - Ligand-induced domain motion in the activation mechanism of a G-protein coupled receptor Protein Engng. 1994, 7:1441-1448. Abstract  

A88. Zhang, D. and Weinstein, H. - Polarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsin. FEBS Letters 1994, 337:207-212.

A87. Zhou, W., Flanagan, C., Ballesteros, J.A., Konvicka, K., Davidson, J.S., Weinstein, H., Millar, R.P., Sealfon, S. - A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol. Pharmacol. 1994, 45:165-170. PubMed

A86. Zhang, D. and Weinstein, H. - Ligand selectivity and the molecular properties of the 5–HT2 receptor: Computational simulations reveal a major role for transmem-brane helix 7. Med. Chem Res., 1993 , 3:357-369.

A85. Pardo, L., Osman, R., Weinstein, H. and Rabinowitz, J.R. - Mechanisms of nucleophilic addition to activated double bonds: The 1,2- and 1,4-Michael addition of ammonia. J. Amer. Chem. Soc. 1993, 115: 8263-8269.

A84. Mehler, E.L., Kushick, J.N. and Weinstein, H. - Consequences of sequential Ca2+ occupancy for the structure and dynamics of calbindinD9k: Computational simulations and comparison to experimental determinations in solution. Mol. Simulation 1993, 10:309-334.

A83. Zhang, D., and Weinstein, H.- Signal transduction by a 5-HT2 receptor: A mechanistic hypothesis from molecular dynamics simulations of the 3-D model of the receptor complexed to ligands. J. Med. Chem. 1993, 36:934-938.

A82. Miaskiewicz, K., Osman, R. and Weinstein, H. - Molecular dynamics simulation of the hydrated d(CGCGAATTCGCG)2 dodecamer. J. Amer. Chem. Soc. 1993, 115:1526-1537.

A81. Ballesteros, J.A. and Weinstein, H. - The role of Pro/Hyp-kinks in determining the transmembrane helix length and gating mechanism of a [Leu]zervamicin channel. Biophys. J., 1992, 62:110-111. Abstract        Full text (with subscription)

A80. Ballesteros, J.A. and Weinstein, H. - Analysis and refinement of criteria for predicting the structure and relative orientations of transmembranal helical domains. Biophys. J., 1992, 62:107-109. PubMed

A79. Pardo, L., Ballesteros, J.A., Osman, R. and Weinstein, H. On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the 3-D structure of G-protein coupled receptors. Proc. Natl. Acad. Sci. USA, 1992, 89:4009-4012. PubMed

A78. Pascual-Ahuir, J.L., Mehler, E.L. and Weinstein, H. - Calmodulin structure and function: Implication of arginine residues in the compaction related to ligand binding. Molec. Engineering, 1991, 1:231-247.

A77. Haaksma, E., Timmerman, H., and Weinstein, H. – The effect of a protein environment on the proposed activation mechanism of the histamine H2- receptor. Isr. J. Chem., 1991, 31:409-421.

A76. Mehler, E.L., Pascual-Ahuir, J.L. and Weinstein, H. – Structural dynamics of calmodulin and troponin C. Protein Engineering, 1991, 4:625-637. Abstract       

A75. Osman, R., Pardo, L., Banfelder, J., Mazurek, A.P., Shvartzman, L., Strauss, R. and Weinstein, H. – Molecular mechanisms of radiation induced DNA damage: H-addition to bases, direct ionization and double strand break. Free Rad. Res. Comms., 1991, 12–13:465-467. PubMed

A74. Pardo L., Osman, R., Banfelder J., Mazurek, A.P. and Weinstein, H. - Molecular mechanisms of radiation-induced DNA damage: H-abstraction and beta-cleavage. Free. Rad. Res. Comms., 1991, 12-13:461-463. PubMed

A73. Weinstein, H. and Osman, R.- On the structural and mechanistic basis of function, classification and ligand design for 5-HT receptors., Neuropsychopharmacol.,1990, 3:397-409. PubMed

A72. Osman, R., Clark, W.J., Mazurek, A.P., and Weinstein, H. - Theoretical studies of molecular mechanisms of DNA damage induced by hydroxyl radicals. Free Rad. Res. Comms. 1989, 6:131-132. PubMed

A71. Pardo, L., Mazurek, A.P. Osman, R. and Weinstein, H. - Theoretical studies of the activation mechanism of histamine H2-receptors: Dimaprit and the receptor model. Int. J. Quantum Chem. 1989, QBS16:281–290

A70. Sussman, F. and Weinstein, H. - On the ion selectivity in Ca-binding proteins: The cyclo-(l-Pro-Gly)3 peptide as a model. Proc. Natl. Acad. Sci. USA, 1989, 86:7880-7884.

A69. Carrol M.T., Cheeseman, J.R., Osman, R. and Weinstein, H. - Nucleophilic addition to activated double bonds: Predictions of reactivity from the Laplacian of charge densities. J. Phys. Chem. 1989, 93:5120-5123.

A68. Gannon, M.N., Hough, L.B. and Weinstein, H.-A metactoid sensitization model to describe multiple receptors linked to a common response: Application to histamine receptors coupled to 3H-cAMP accumulation in guinea pig cortex. Mol. Pharmacol., 1989, 35:205-213.

A67. Mercier, G.A., Osman, R. and Weinstein, H.- Role of primary and secondary protein structure in neurotransmitter receptor activation mechanisms. Protein Engineering, 1988, 2:261-270. Abstract

A66. Dijkman, J.P., Osman, R. and Weinstein, H. - A theoretical study of the effect of primary and secondary structure elements on the proton transfer in Papain. Int. J. Quantum Chem., 1988, 35:241-252.

A65. Hori, K., Kushick, J.N., and Weinstein, H. - Structural and energetic parameters of Ca2+ binding to peptides and proteins. Biopolymers, 1988, 27:1865-1886.

A64. Hori, K., Kushick, J.N., Factor, A. and Weinstein, H. - Parameters and mechanisms of calcium binding to peptides and proteins. Int. J. Quantum Chem., 1987, QBS 14:341-345.

A63. Dijkman, J.P., Osman, R. and Weinstein, H. - Practical considerations in calculations of the proton transfer in a model active site of papain. Int. J. Quantum Chem., 1987, QBS 14:211-219.

62. Osman, R., Topiol, S., Rubenstein, L. and Weinstein, H. - A molecular model for activation Aof a 5-hydroxytryptamine receptor. Mol. Pharmacol., 1987, 32:699-705.

A61. Osman, R., Namboodiri, K., Weinstein, H. and Rabinowitz, J.R. - Reactivities of acrylic and methacrylic acids in a nucleophilic addition model of their biological activities. J. Amer. Chem. Soc., 1988, 110:1701-1707.

A60. Namboodiri, K., Osman, R., Weinstein, H. and Rabinowitz, J.R.-Analysis of the molecular electrostatic potential for the prediction of N-oxidation and biological activity of substituted pyridines. Mol. Toxicol., 1987, 1:131-141. PubMed

A59. Shenker, A., Maayani, S., Weinstein, H. and Green, J.P. - Pharmacological characteri-zation of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes. Mol. Pharmacol., 1987, 31:357-367. PubMed

A58. Mazurek, A.P., Osman, R. and Weinstein, H. - Molecular determinants for recognition of triazole and tetrazole analogs of histamine at H2-receptors. Mol. Pharmacol., 1987, 31:345-350. PubMed

A57. Reggio, P,. Topiol, S. and Weinstein, H. -Molecular determinants for the agonist activity of 2-methylhistamine and 4-methylhistamine at H2-receptors. J. Med. Chem, 1986, 29:2412-2415.

A56. Newton, M.V., Hough, L.B. and Weinstein, H. - A metactoid sensitization model for the classification of histamine receptors coupled to 3H-cAMP accumulation in a vesicular preparation of guinea pig cerebral cortex. Ann. N.Y. Acad. Sci., 1987, 494:243-246.

A55. Weinstein, H., Mazurek, A.P., Osman, R. and Topiol, S. - Theoretical studies on the activation mechanism of the histamine H2-receptor: The proton transfer between histamine and a receptor model. Mol. Pharmacol., 1986, 29:28-33. PubMed

A54. Rabinowitz, J.R., Namboodiri, K., and Weinstein, H. - A finite expansion method for the calculation and interpretation of molecular electrostatic potentials. Int. J. Quantum Chem., 1986, 29:1697-1704.

A53. Topiol, S. Mercier, G., Osman, R. and Weinstein, H., - Computational schemes for modeling proton transfer in biological systems: Calculations on the hydrogen bonded complex [CH3OH.H.NH3]+. J. Comput. Chem., 1985, 6:581-586.

A52. Shenker, A., Maayani, S., Weinstein, H. and Green, J.P. - Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone. Eur. J. Pharmacol. 1985, 109: 427-429.

A51. Liebman, M.N., Venanzi, C.A. and Weinstein, H. - Structural analysis of carboxypeptidase A and its complexes with inhibitors as a basis for modeling enzyme recognition and specificity. Biopolymers, 1985, 24:1721-1758.

A50. Mazurek, A.P., Weinstein, H., Osman, R., Topiol, S. and Ebersole, B.J. -Theoretical and experimental studies of drug-receptor interactions: Determinants for recognition of 5-hydroxytryptamine analogs. Int. J. Quantum Chem. 1984, QBS 11:183-194.

A49. Topiol, S., Weinstein, H. and Osman, R. - A theoretical investigation of histamine tautomerism. J. Med. Chem., 1984, 27:1531-1533. PubMed

A48. Ebersole, B.J., Weinstein, H. and Maayani, S. - Differences in 3H-d-lysergic acid diethylamide binding in mouse cortex and hippocampus in vivo and in vitro revealed by radioautography and rapid filtration studies. J. Pharmacol. Exp. Ther. 1984, 228:865-871.

A47. Aguayo, L.G., Weinstein, H., Maayani, S., Glick, S.D., Warnick, J.E. and Albuquerque, E.X. - Discriminant effects of behaviorally active and inactive analogs of phencyclidine on membrane electrical excitability. J. Pharmacol. Exp. Ther. 1984, 228:80-87.

A46. Weinstein, H., Maayani, S., Pazhenchevsky, B., Venanzi, C. and Osman, R. -Molecular determinants for recognition of phencyclidine derivatives at muscarinic cholinergic receptors. Int. J. Quantum Chem. 1983, QBS10:309-320.

A45. Mazurek, P.A., Topiol, S., Weinstein, H. and Osman, R. - Theoretical studies on the activation mechanism of the histamine H2-receptor: The guanidine substitution and its role in the partial agonism of N(alpha)-guanylhistamine. Int. J. Quantum Chem. 1983, QBS10:293-300. PubMed

A44. Shenker, A., Maayani, S., Weinstein, H. and Green, J.P. - Enhanced serotonin-stimulated adenylate cyclase activity in membranes from adult guinea pig hippocampus. Life Sci. 1983, 32:2335-2342.

A43. D'Amico, G.A., Kline, R.P., Maayani, S., Weinstein, H. and Kupersmith, J. - Effects of phencyclidine on cardiac action potential: pH dependence and structure-activity relationships. Eur. J. Pharmacol. 1983, 88:283-290.

A42. Weinstein, H., Maayani, S. and Pazhenchevsky, B. - Multiple actions of PCP: Discriminant SAR from molecular conformations and assay conditions. Fed. Proc. 1983, 42:2574- 2578.

A41. Venanzi, C.A., Weinstein, H., Corongiu, G. and Clementi, E. - The solvent effect in enzyme-substrate interactions: Models of carboxypeptidase. Int. J. Quantum Chem. 1982, QBS9:355-365.

A40. Aguayo, L.G., Warnick, J.E., Maayani, S., Glick, S.D., Weinstein, H. and Albuquerque, E.X. - Sites of action of phencyclidine IV. Interaction of phencyclidine and its analogs on ionic channels of the electrically excitable membrane and nicotinic receptor: Implications for behavioral effects. Mol. Pharmacol.1982, 21:637-647.

A39. Albuquerque, E.X., Aguayo, L.G., Warnick, J.E., Weinstein, H., Glick, S.D., Maayani, S., Ickowicz, R.K. and Blaustein, M.P. - The behavioral effects of phencyclidine may be due to their blockade of potassium channels. Proc. Natl. Acad. Sci. U.S.A. 1981, 78:7792-7796.

A38. Reggio, P.H., Weinstein, H., Osman, R. and Topiol, S. - Molecular determinants for binding of methylenedioxytryptamines at 5-HT/LSD receptors. Int. J. Quantum Chem. 1981, QBS8:373-384.

A37. Osman, R., Topiol, S. and Weinstein, H. - Electron density redistribution in the stabilization of a molecular stacking complex: The nature and correction of basis set superposition errors. J. Comput. Chem. 1981, 2:73-82.

A36. Osman, R., Topiol, S., Weinstein, H. and Eilers, J.E. - Theoretical studies of molecular complexes: A probe into basis set and correlation effects, Chem. Phys. Letters, 1980, 73:399-403.

A35. Maayani, S. and Weinstein, H. - "Specific binding" of 3H-phencyclidine: Artifacts of the rapid filtration method, Life Sci. 1980, 26:2011-2022.

A34. Osman, R. and Weinstein, H. - Models for active sites of metalloenzymes: comparison of zinc and beryllium containing complexes. Isr. J. Chem. 1980, 19:149-153. PubMed

A33. Politzer, P. and Weinstein, H. - Some relations between electronic distribution and electronegativity, J. Chem. Phys. 1979, 17:4218-4220.

A32. Kang, S., Ernst, L., Weinstein, H. and Osman, R. - 13C NMR chemical shifts and calculated electronic structures of serotonin congeners: relation to biological activity, Mol. Pharmacol. 1979, 16:1031-1039. PubMed

A31. Johnson, C.L., Weinstein, H. and Green, J.P. - Studies on histamine H2-receptors coupled to cardiac adenylate cyclase. II. Blockade by H2 and H1 receptor antagonists, Mol. Pharmacol. 1979, 16:417-428.

A30. Johnson, C.L., Weinstein, H. and Green, J.P. - Studies on histamine H2-receptors coupled to cardiac adenylate cyclase. I. Effects of guanylnucleotides and structural requirements for agonist activity, Biochim. Biophys. Acta. 1979, 587:155-168.

A29. Chang, S.Y. and Weinstein, H. - Perturbation treatment of multiple site reactivity.II: Additivity in trimolecular interactions, Int. J. Quantum Chem. 1978, 14:801-813.

A28. Weinstein, H., Osman, R., Edwards, W.D. and Green, J.P. - Theoretical models for molecular mechanisms in biological systems: tryptamine congeners on an LSD/serotonin receptor, Int. J. Quantum Chem. 1978, QBS5:449-461. PubMed

A27. Edwards, W.D. and Weinstein, H. - On the basis set dependence of reported limitations in predictions from electrostatic potentials, Chem. Phys. Letters 1978, 56:582-584.

A26. Chou, D. and Weinstein, H. - Electron charge redistribution following electrophilic attack on heterocycles: nitrogen as a charge transducer, Tetrahedron, 1978, 34:275-286.

A25. Green, J.P., Johnson, C.L., Weinstein, H. and Maayani, S. - Antagonism of the histamine-activated adenylate cyclase in brain by D-LSD, Proc. Nat. Acad. Sci. U.S.A., 1977, 74:5697-5701.

A24. Weinstein, H., Eilers, J.E. and Chang, S.Y. - A modified Hamiltonian method for the study of multiple site reactivity: comparison with perturbation results, Chem. Phys. Letters, 1977, 54:534-539.

A23. Weinstein, H. and Osman, R. - Models for molecular mechanisms in drug- receptor interactions: serotonin and 5-hydroxyindole complexes with imidazolium cation, Int. J. Quantum Chem. 1977, QBS4:253-268.

A22. Osman, R. and Weinstein, H. - Near ab-initio methods for the calculation of large molecules: comparison of pseudopotential and ab-initio results Chem. Phys. Letters 1977 , 49:69-74.

A21. Weinstein, H., Srebrenik, S., Maayani, S. and Sokolovsky, M. - A theoretical model study of the comparative effectiveness of atropine and scopolamine action in the central nervous system, J. Theor. Biol. 1977, 64:295-309.

A20. Weinstein, H., Chou, D., Johnson, C.L. and Green, J.P. - Tautomerism and the receptor action of histamine--a mechanistic model, Mol. Pharmacol. 1976, 12:738-745.

A19. Chang, S.Y., Weinstein, H. and Chou, D. - Perturbation treatment of multiple site reactivity: Molecule-molecule interactions, Chem. Phys. Letters, 1976 ,42:145-150.

A18. Weinstein, H., Chou, D., Kang, S., Johnson, C.L. and Green, J.P. - Reactivity characteristics of large molecules and their biological activity: Indolealkylamines on the LSD-serotonin receptor, Int. J. Quantum Chem. 1976, QBS3:135-150.

A17. Weinstein, H. - Some new quantum chemical procedures for the analysis of drug-receptor interactions, Int. J. Quantum Chem. 1975, QBS2:59-69.

A16. Weinstein, H., Maayani, S., Srebrenik, S., Cohen, S. and Sokolovsky, M. - A theoretical and experimental study of the semi-rigid cholinergic agonist-3-acetoxy-quinuclidine, Mol. Pharmacol. 1975, 11:671-689.

A15. Politzer, P. and Weinstein, H. - Molecular electrostatic potentials II. Mechanistic aspects of electrophilic interactions of some five-membered heterocycles, Tetrahedron 1975, 31:915-923.

A14. Srebrenik, S., Pauncz, R. and Weinstein, H. - Some definitions of atomic regions in molecules and solids, Chem. Phys. Letters 1975 , 32:420-425.

A13. Bartlett, R.J. and Weinstein, H. - Theoretical treatment of multiple site reactivity in large molecules, Chem. Phys. Letters 1975, 30:441-445.

A12. Weinstein, H., Politzer, P. and Srebrenik, S. - A misconception concerning the electronic density distribution of an atom, Theor. Chim. Acta. 1975, 38:159-163.

A11. Kistenmacher, T.J., Shigematsu, T. and Weinstein, H. - The effect of substitutionon protonation sites: evidence for protonation at N(3) in N(7)-substituted adenine, J. Mol. Struct. 1975 , 25:125-129.

A10. Weinstein, H. - On the possible use of analytic potentials in Scattered Wave methods, Int. J. Quantum Chem. 1974, S8:123-125.

A9. Srebrenik, S., Weinstein, H. and Pauncz, R. - The formulation of molecular forces and their analytic calculations, J. Chem. Phys. 1974 , 61:5050-5053.

A8. Maayani, S., Weinstein, H., Ben-Zvi, N., Cohen, S. and Sokolovsky, M. - Psychomimetics as anticholinergic agents I. 1-cyclohexylpiperidine derivatives: anticholinesterase activity and antagonistic activity to acetylcholine, Biochem. Pharm. 1974 , 23:1263-1281.

A7. Paster, A., Maayani, S., Weinstein, H. and Sokolovsky, M. - Cholinolytic action of phencyclidine derivatives, Eur. J. Pharmacol. 1974 , 25:270-274.

A6. Maayani, S., Weinstein, H., Cohen, S. and Sokolovsky, M. - Acetylcholine-like molecular arrangement in psychomimetic anticholinergic drugs, Proc. Natl. Acad. Sci., U.S.A. 1973 , 70:3103-3107.

A5. Weinstein, H., Maayani, S., Srebrenik, S., Cohen, S. and Sokolovsky, M. Psychotomimetics as anticholinergic agents II. Quantum Mechanical study of molecular interaction potentials of 1-cyclohexylpiperidine with the cholinergic receptor, Mol. Pharmacol. 1973 , 9:820-834.

A4. Srebrenik, S. Weinstein, H. and Pauncz, R. - Analytical calculations of atomic and molecular electrostatic potentials from the Poisson equation, Chem. Phys. Letters 1973 , 20:419-423.

A3. Weinstein, H., Apfelderfer, B.Z. and Berg, R.A. - Quantum mechanical analysis of electronic transitions in some cyanine dye photosensitizers, Photochem. Photobiol. 1973 , 18:175-183.

A2. Weinstein, H. and Pauncz, R. - Direct optimization approach to molecular electron density calculation, Chem. Phys. Letters, 1972 , 14:161-166.

A1. Weinstein, H. and Pauncz, R. - Molecular orbital set determined by a localization procedure. Symp. Far. Soc. 1968 , 23-31.

 

B. Reviews, Symposia and Books

B66. Majek, P, Elber, R and Weinstein, H – Pathways of conformational transitions in proteins. In: Coarse-Graining of Condensed Phase and Biomolecular Systems, Ed., G. Voth, Taylor and Francis, Publ. 2008

B65. Gümüs, ZH, Du, B, Mukherjee, P, Subbaramaiah, K, Dannenberg, AJ and Weinstein, H. - Systematic analysis of tobacco smoke induced changes in oral epithelial cell transcriptome. AACR Meeting 2006:B103.

B64. Filizola, M., Guo, W., Javitch, J.A. and Weinstein, H. – Oligomerization domains in G-protein coupled receptors: Insights into the structural basis of GPCR association. In The G-protein Coupled Receptor Handbook, Ed. L.A. Devi, Series: Contemporary Clinical Neuroscience, Humana Press, Inc. Totowa, NJ 2005, pp.243-265.

B63. Weinstein H. - New levels of complexity in the functional roles of modular protein interaction domains: Switches and sockets in the circuit diagrams of cellular Systems Biology. In: Eds. G. Cesareni, M. Gimona, M. Sudol and M. Yaffe, Wiley-VCH, GmbH, 2004, pp.487-491.

B62. Goldberg, N.R., Beuming, T., Weinstein H., and Javitch, J. – A structural context for studying neurotransmitter transporter function In Strategies in Molecular Neuropharmacology, Eds., A. Schousboe and H. Bräuner-Osborne, Humana Press, 2003, Chapter 12, pp.213-234.

B61. Filizola, M., Visiers, I., Skrabanek, L., Campagne, F. and Weinstein H. – Functional mechanisms of GPCRs in a structural context. In Strategies in Molecular Neuropharmacology, Eds., A. Schousboe and H. Bräuner-Osborne, Humana Press, 2003, Chapter 13, pp.235-266.

B60. Hassan, S.A., Mehler, E.L. and Weinstein H. Structure calculation of protein segments connecting domains with defined secondary structure: A simulated annealing Monte Carlo combined with biased Scaled Collective Variables technique. In International Workshop on Methods for Macromolecular Modeling, Ed. T. Schlick, Springer Verlag, 2002, pp.197-231.

B59. Visiers, I. Ballesteros, J.A., and Weinstein, H. Computational methods for the construction and analysis of three dimansional representations of GPCR structures and mechanisms. In: Methods in Enzymology 2002, pp. 329-371.

B58. Pastor, N., and Weinstein, H. - Protein-DNA interactions in the initiation of transcription: The role of flexibility and dynamics of the TATA recognition sequence and the TATA box binding protein. In: Theoretical Biochemistry; Ed., Leif Eriksson, Elsevier Science B.V., Amsterdam, 2001, pp. 377-407.

B57. Scheraga, H. and Weinstein, H. (Guest Editors) – Intl.J. Quantum Chemistry Vol. 75 Number (3),1999: Biophysics Quarterly In Memory of Bernard Pullman, pp. 135-330.

B56. Pastor, N., Pardo, L. and Weinstein, H. - How the TATA box selects its protein partner. In: Molecular Modeling of Nucleic Acids; ACS Symposium Series No. 682; Eds., N.B. Leontis, and J. SantaLucia, Jr., 1997, pp. 329-345.

B55. Sassaroli, M. and Weinstein, H. - Book Review: S.H. White, Editor: Membrane Protein Structure: Experimental approaches. The Physiologist, 1996.

B54. Weinstein, H. - E pur si muove: Dynamic modeling of ligand-induced activation in G-protein coupled receptors. Chemical Design & Automation 1995, 10(2):1&39-43.

B53. Ballesteros, J.A. and Weinstein, H.- Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G-protein coupled receptors Methods Neurosci. 1995, 25:366-428.

B52. Weinstein, H. and Zhang, D. - Receptor models and ligand-induced responses: New insights for structure-activity relations. "QSAR and Molecular Modeling: Concepts, Computational Tools and Biological Applications" F. Sanz, J. Giraldo and F. Manaut (Eds.) J.R. Prous Science Publ. , Barcelona, 1995 , pp. 497-507.

B51. Weinstein, H. and Mehler, E.L.- Ca2+-binding and structural dynamics in the functions of calmodulin. Ann. Rev. Physiol . 1994, 56:213-236.

B50. Weinstein, H., Zhang, D. and Ballesteros, J.A- Hallucinogens acting at 5-HT receptors: Towards a mechanistic understanding at atomic resolution. In: Hallucinogens: An Update, Eds., G. Lin and R.A. Glennon, National Inst. on Drug Abuse Research Monograph #146, 1994, pp.241-262.

B49. Weinstein, H. - Computational simulations of molecular structure, dynamics and signal transduction in biological systems: Mechanistic implications for ecological physical chemistry. In: Ecological Physical Chemistry, Eds., L. Bonati, U. Cosentino, M. Lasagni, D. Pitea and A. Schiraldi. Elsevier, Amsterdam, 1992, pp.1-16.

B48. Weinstein, H. and Mehler, E.L.- Structural specificity in the engineering of biological functions: Insights from the dynamics of calmodulin. In: The Role of Computational Models and Theories in Biotechnology, Ed., J. Bertran, Kluwer, Dordrecht 1992, pp.153-173.

B47.  Osman, R., Miaskiewicz, K. and Weinstein, H. - Structure-function relations in radiation damaged DNA. In: Physical and Chemical Mechanisms in Molecular Radiation Biology , Eds., W.A. Glass and M. N. Varma, Plenum Press, New York 1991, pp.423-451. PubMed

B46. Haaksma, E.E.J., Donne- Op den Kelder, G.M., Timmerman, H. and Weinstein, H. - Theoretical analysis of the activity of dimaprit derivatives on the H2 receptor. In: New Perspectives in Histamine Research, H. Timmerman and H. Van der Goot, eds., Birkhauser Verlag, Basel, 1991, pp.315-324.

B45. Weinstein, H. - On the chemical basis of specificity and function in biological mechanisms. In: Proc. 6th IFC Symposium, Kyoto, Institute for Fundamental Chemistry , Kyoto, Japan 1991, pp. 169-182.

B44. Weinstein, H., Osman, R., Mercier, G.A.,Mazurek, A.P., Pardo, L., and Rubenstein, L.A. - Theory and computation of molecular mechanisms in biological processes: Radiation-induced damage to DNA and neurotransmitter receptor function; In: Computer Assisted Analysis and Modeling on the IBM 3090, H. U. Brown, ed., MIT Press, Boston, 1990, pp. 629-673.

B43. Weinstein, H. and Osman, R. - Simulations of ligand-receptor interactions as guides for design. In: Frontiers in Drug Research, Alfred Benzon Symposium 28, B. Jensen, F.S. Jorgensen and H. Kofod, eds., Munksgaard, Copenhagen, 1990, pp. 169-182.

B42. Weinstein, H., and Osman, R. - Molecular biophysics of specificity and function in enzymes, receptors and calcium binding proteins. In: Theoretical Biochemistry and Molecular Biophysics: A Comprehensive Survey, D.L. Beveridge and R. Lavery, eds, Adenine Press, NY 1990, pp. 275-289.

B41. Weinstein, H., Hori, K., Kushick, J.N., Sussman, F. and Factor, A. - Computer simulation studies of structure-function relations in calcium-binding proteins. In: Proc. 4th Intl. Conf. Supercomputing, L.P. Kartashev and S.I. Kartashev, eds., Intl. Supercomputing Inst., Inc., Florida, 1989, pp. 106-108.

B40. Weinstein, H. and Osman, R. - Interaction mechanisms at biological targets: Implications for design of serotonin receptor ligands. In: Computer Aided Molecular Design, G.W. Richards, ed., IBC Technical Services, Ltd., London, 1989, pp. 105-118.

B39. Weinstein, H., Osman, R. and Mercier, G.A.-Recognition and activation of a 5-HT receptor by hallucinogens and indole derivatives. In:NIDA Research Monograph 90, Proc. 50th Ann. Meet. Problems of Drug Dependence, L.S. Harris, ed., 1988, pp.243-255. PubMed

B38. Mercier, G.A., Dijkman, J.P., Osman, R. and Weinstein, H. - Effects of macromolecular environments on proton transfer processes: The calculation of polarization. In: Quantum Chemistry: Basic Aspects, Actual Trends, R. Carbo, ed., Elsevier Scientific Publ., Amsterdam, 1989; pp. 577-596.

B37. Mercier, G.A., Osman, R. and Weinstein, H. - A molecular theoretical model of recognition and activation at a 5-HT receptor. In: Computer Assisted Modeling of Receptor - Ligand Interactions, R. Rein and A. Golombek, eds., Alan R. Liss, Publ., New York, 1989, pp.339-410. PubMed

B36. Weinstein, H. - Classification based on ligand binding: On the chemical meaning of ligand Baffinity in studies of drug-receptor interactions. In: Perspectives on Receptor Classification, J. W. Black, P. Gerskowitz and D. Jenkinson, eds., Alan R. Liss Publ., New York, 1987, pp. 41-49.

B35. Weinstein, H. - Molecular models for muscarinic ligands. Trends in Pharmacol. Sci,. 1986, (July) 7:262-263.

B34. Weinstein, H. - On the role of computational approaches to enzyme structure and function in the study of molecular processes in biology. Enzyme, 1986 , 36:4-7.

B33. Weinstein, H. (ed.) - Computational Approaches to Enzyme Structure and Function. Karger, Scientific Publ., Basel, 1986.

B32. Weinstein, H., Osman, R. and Mazurek, A. P. - Simulations of molecular stereoelectronic mechanisms for the interaction of hallucinogens and indole derivatives at 5-HT receptors. In: Steric Aspects of Biomolecular Interactions, G. Naray - Szabo and S. Kalman, eds., CRC Press, Florida, 1987, pp. 199-210.

B31. Weinstein, H., Namboodiri, K., Osman, R., Liebman, M.N. and Rabinowitz, J. - The use of molecular reactivity criteria to predict toxicity of xenobiotics. In: QSAR in Toxicology and Xenobiochemistry, M. Tichy, ed., Elsevier- Amsterdam, New York, 1985, pp. 451-463.

B30.  Osman, R., Weinstein, H., Topiol, S. and Rubenstein, L. - A Molecular theory of recognition and activation at a 5-HT receptor based on a quantum chemical approach to structure activity relationships. Clin. Physiol. Biochem. 1985, 3:80-88. PubMed

B29. Liebman, M.N. and Weinstein, H. - Heuristic studies of structure-function relationships in enzymes: Carboxypeptidase and thermolysin, In: Structure and Motion: Membranes, Nucleic Acids and Proteins. E. Clementi, G. Corongiu, M.H. Sarma and R.H. Sarma, eds., Adenine Press, N.Y., 1985, pp. 339-359.

B28. Weinstein, H., Rabinowitz, J., Liebman, M.N. and Osman, R. - Determinants of molecular reactivity as criteria for predicting toxicity: Problems and approaches. Environmental Health Perspectives, J. McKinney, ed., NIEHS, 1985, 61:147-162. PubMed

B27. Weinstein, H., Liebman, M.N. and Venanzi, C.A. - Theoretical principles of drug action: The use of enzymes to model receptor recognition and activity. In: New Methods in Drug Research. I ., A. Makriyannis, ed., J.R. Prous, S.A., Publ., Barcelona, 1985, pp. 233-246.

B26. Albuquerque, E.X., Warnick, J.E., Aguayo, L.G., Ickowicz, R.K., Blaustein, M.P., Maayani, S. and Weinstein, H. - Phencyclidine: Differentiation of behaviorally active from inactive analogs based on interactions with channels of electrically excitable membranes and of cholinergic receptors. In: Phencyclidine and Related Arylcyclohexylamines: Present and Future Applications, E.G. Domino and P. Geneste, eds., NPP Books, Ann Arbor, Michigan, 1983, 579-594.

B25. Weinstein, H., Osman, R., Topiol, S. and Venanzi, C.A. - Molecular determinants for biological mechanisms: Model studies of interactions in carboxypeptidase. In: Quantitative Approaches to Drug Design, J.C. Dearden, ed. Elsevier Science Publ., Amsterdam, Holland, 1983, pp. 81-90.

B24. Maayani, S., Hough, L.B., Weinstein, H. and Green, J.P. - Response of the histamine H2-receptor in brain to antidepressant drugs. In: Typical and Atypical Antidepressants, Adv. Biochem. Psychopharmacol. 31 : eds. E. Costa and G. Racagni, (Raven, New York), 1982, pp. 133-147.

B23. Green, J.P. and Weinstein, H. - Recognition, response. Quantum mechanics can account for the affinities of drugs and receptors. The Sciences 1981 (September), 21:27-29.

B22. Weinstein, H., Topiol, S. and Osman, R. - On the relation between charge redistribution and intermolecular forces in models for molecular interactions in biology. In: Intermolecular Forces, B. Pullman, ed. D. Reidel Publ. Co., Dordrecht, Holland, 1981, pp. 383-396.

B21.  Osman, R., Weinstein, H. and Topiol, S. - Models for active sites of metalloenzymes. II. Interactions with a model substrate. Ann. N.Y. Acad. Sci., 1981, 367:356-369. PubMed

B20. Topiol, S., Osman, R. and Weinstein, H. - Effective potential methods for use in electronic structure calculations of large molecules. Ann. N.Y. Acad. Sci. 1981, 367:17-34.

B19. Weinstein, H., Osman, R., Topiol, S. and Green, J.P. - Quantum chemical studies on molecular determinants of drug action. Ann. N.Y. Acad. Sci. 1981, 367:434-451. PubMed

B18. Weinstein, H., Osman, R., Green, J.P. and Topiol, S. - Electrostatic potentials as descriptors of molecular reactivity: The basis for some successful predictions of Pbiological activity. In: "Chemical Applications of Atomic and Molecular Electrostatic Potentials," eds. P. Politzer and D.G. Truhlar (Plenum Press, N.Y.) 1981, pp. 309-323.

B17. Weinstein, H. and Green, J.P., (eds) -Quantum Chemistry in Biomedical Sciences. Ann. N.Y. Acad. Sci. 1981, Vol. 367, 552 pp.

B16. Weinstein, H., Maayani, S., Glick, S.D. and Meibach, R.C. - Integrated studies on the biochemical, behavioral and molecular pharmacology of phencyclidine - A progress report. In: PCP (Phencyclidine): Historical and Current Perspectives. ed. E.F. Domino (NPP Books, Ann Arbor, Michigan), 1981, pp. 131-175.

B15. Hough, L.B., Weinstein, H. and Green, J.P. - One agonist and two receptors mediating the same effect: histamine receptors linked to adenylate cyclase in brain. In: Receptors for Neurotransmitters and Peptide Hormones , ed. G. Pepeu, M.J. Kuhar, and S.J. Enna (Raven, New York), 1980, pp. 183-192.

B14. Weinstein, H., Osman, R. and Green, J.P. - The molecular basis of structure-activity relationships: quantum chemical recognition mechanisms in drug-receptor interactions. In: Computer-Assisted Drug Design. ACS Symposium Series 112, ed. E.O. Olson and R.E. Christoffersen (American Chemical Society, Washington, D.C.), 1979, pp. 161-187.

B13.  Osman, R., Weinstein, H. and Green, J.P. - Parameters and methods in quantitative structure-activity relationships. In: Computer-Assisted Drug Design. ACS Symposium Series 112, ed. E.O. Olson and R.E. Christoffersen (American Chemical Society, Washington, D.C.), 1979, pp. 21-77.

B12. Weinstein, H., Green, J.P., Osman, R. and Edwards, W.D. - Recognition and activation mechanisms on the LSD/serotonin receptor: the molecular basis of structure activity relationships. In: QuaSAR, Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens, NIDA Monograph 22, ed. G. Barnett, M. Trsic and R.E. Willette (U.S. Government Printing Office), 1978, pp. 333-358.

B11. Green, J.P., Weinstein, H. and Maayani, S. - Defining the histamine H2-receptor in brain: the interaction with LSD. In: QuaSAR, Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens, NIDA Research Monograph 22 ed. G. Barnett, M. Trsic, and R.E. Willette (U.S. Government Printing Office), 1978, pp. 38-59.

B10. Maayani, S. and Weinstein, H. - Some structure activity relationships of phencyclidine derivatives as anticholinergic agents in vitro and in vivo. In: Membrane Mechanisms of Drugs of Abuse, eds. C. Wm. Sharp and L. Abood, Allan R. Liss Publ., New York, 1979, pp. 91-106.

B9. Green, J.P., Johnson, C.L. and Weinstein, H. - Histamine activation of adenylate cyclase in brain: an H2-receptor and its blockade by LSD. In: Histamine Receptors, ed. T.O. Yellin, Spectrum Publications 1978, pp. 185-210.

B8. Green, J.P., Johnson, C.L., Weinstein, H., Kang, S. and Chou, D. -Molecular determinants for interaction with the LSD receptor: biological studies and quantum chemical analysis. In: The Psychopharmacology of Hallucinogens, eds. R.E. Willette and R.C. Stillman, Pergamon Press, 1978, pp. 28-60.

B7. Green, J.P., Johnson, C.L. and Weinstein, H. - Histamine as a neurotransmitter. In: Psychopharmacology - A generation of progress, eds. M. Lipton, A. DiMascio and K. Killam, Raven Press, New York, 1977, pp. 319-332.

B6. Loew, G., Weinstein, H. and Berkowitz, D. - Theoretical study of the solvent effect on ionization and partition behavior of related opiate narcotics: hydromorphone and oxymorphone. In: Environmental Effects on Molecular Structure and Properties, ed. B. Pullman, D. Reidel Publ. Co., Dordrecht-Holland/Boston, 1976, pp. 239-258.

B5. Loew, G., Berkowitz, D., Weinstein, H. and Srebrenik, S. - Quantum chemical studies of morphine-like opiate narcotics: effect of polar group variations. In: Molecular and Quantum Pharmacology , eds. E.D. Bergmann and B. Pullman, D. Reidel Publishing Co., Dordrecht-Holland/Boston, 1974, pp. 355-389.

B4. Weinstein, H., Srebrenik, S., Pauncz, R., Maayani, S., Cohen, S. and Sokolovsky, M. - Characterization of drug-receptor interactions in cholinergic systems by molecular interaction potentials. In: Chemical and Biochemical Reactivity, eds. E.D. Bergmann and B. Pullman, D. Reidel, Dordrecht/Boston, 1974, pp. 493-512.

B3. Halevi, E.A., Pauncz, R., Schek, I. and Weinstein, H. - Multiplicity changes during thermal dissociation. In: Chemical and Biochemical Reactivity, eds. E.D. Bergmann and B. Pullman, D. Reidel, Dordrecht/ Boston, 1974, pp. 167-182.

B2. Weinstein, H., Apfelderfer, B., Cohen, S., Maayani, S. and Sokolovsky, M.-Molecular orbital study of the conformation of acetylcholine-like molecules. In: The Conformation of Biological Molecules and Polymers - The 5th Jerusalem Symposium, eds. E.D. Bergmann and B. Pullman, Academic Press, New York, 1972, pp. 531-543.

B1. Weinstein, H., Pauncz, R. and Cohen, M. - Localized molecular orbitals Ch III In: Advances in Atomic and Molecular Physics, Vol. 7, eds. I. Esterman and R.D. Bates, Academic Press, New York, 1971, pp. 97-140

physiology@med.cornell.edu | last updated: Friday, September 30, 2005