Faculty::Physiology and Biophysics::WMC::Cornell University

Langhans-Rajasekaran, S.A., Wan, Y., and Huang, X.-Y. 1995. Activation of Tsk and Btk tyrosine kinases by G-protein beta-gamma subunits. Proc. Natl. Acad. Sci. USA. 92:8601-8605.

Wan, Y., Kurosaki, T., and Huang, X.-Y. 1996. Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors. Nature 380:541-544.

Wan, Y., Bence, K., Hata, A., Kurosaki, T., Veillette, A., and Huang, X.-Y. 1997. Genetic evidence for a tyrosine kinase cascade preceding the MAP kinase cascade in vertebrate G protein signaling. J. Biol. Chem. 272:17209-17215.

Bence, K., Ma, W., Kozasa, T., and Huang, X.-Y. 1997. Direct stimulation of Bruton's tyrosine kinase by Gq-protein alpha-subunit. Nature 389:296-299.

Zhou, B.-Y., Ma, W., and Huang, X.-Y. 1998. Specific antibodies to the external vestibule of voltage-gated potassium channels block current. J. Gen. Physiol. 111: 555-563.

Wan, Y., and Huang, X.-Y. 1998. Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells. J. Biol. Chem. 273: 14533-14537.

Ma, Y.-C., and Huang, X.-Y. 1998. Identification of the binding site for Gq-alpha on its effector Bruton's tyrosine kinase. Proc. Natl. Acad. Sci. USA 95: 12197-12201.

Jiang, Y., Ma, W., Wan, Y., Kozasa, T., Hattori, S., and Huang, X.-Y. 1998. The G protein G-alpha-12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH-BM domain. Nature 395: 808-813.

Piros, E.T., Shen, L., and Huang, X.-Y. 1999. Purification of an EH-domain-binding protein from rat brain modulating the gating of the rat EAG channel. J. Biol. Chem. 274:33677-33683.

Gu, C.-H., Ma, Y.-C., Benjamin, J., Littman, D., Chao. M.V., and Huang, X.-Y. 2000. Apoptotic signaling through the beta-adrenergic receptor: A new Gs effector pathway. J. Biol. Chem. 275: 20726-20733.

Aghazadeh, B., Lowry, W., Huang, X.-Y., and Rosen, M. 2000. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell 102: 625-633.

Ma, Y.-C., Huang, J., Ali, S., Lowry, W., and Huang, X.-Y. 2000. Src tyrosine kinase is a novel direct effector of G proteins. Cell 102: 635-646.

Wang, D., Huang, X.-Y., and Cole, P.A. 2001. Molecular determinants for Csk catalyzed tyrosine phosphorylation of the c-Src carboxyl tail. Biochemistry 40: 2004-2010.

Lowry, W.E., Huang, J., Lei, M., Rawlings, D., and Huang, X.-Y. 2001. Role of the PH/TH module in protein substrate recognition by Bruton's agammaglobulinaemia tyrosine kinase. J. Biol. Chem. 276: 45276-45281.

*Zheng, B., *Ma, Y.-C., Ostrom, R.S., Lavoie, C., Gill, G.N., Insel, P.A., Huang, X.-Y., and Farquhar, M. G. 2001. RGS-PX1, a GAP for G-alpha-s and sorting nexin in vesicular trafficking. Science 294: 1939-1942.

Lowry, W.E. and Huang, X.-Y. 2002. G protein beta-gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase. J. Biol. Chem. 277: 1488-1492.

Lowry, W.E., Huang, J., Ma, Y.-C., Ali, S., Wang, D., Williams, D.M., Okada, M., Cole, P.A., and Huang, X.-Y. 2002. Csk, a critical link of G protein signals to actin cytoskeletal reorganization. Developmental Cell 2: 733-744.

Njardarson, J.T., Gaul, C., Shan, D., Huang, X.-Y., and Danishefsky, S.J. 2004. Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. J. Am. Chem. Soc. 126: 1038-1040.

Huang, J.J., Sun, Y., and Huang, X.-Y. 2004. Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization. J. Biol. Chem. 279: 21637-21642.

Cvejic, S., Zhu, Z., Felice, S.J., Berman, Y., and Huang, X.-Y. 2004. The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. Nature Cell Biology 6: 540-546.

Gaul, C., Njardarson, J.T., Shan, D., Dorn, D.C., Wu, K.-D., Tong, W.P., Huang, X.-Y., Moore, M.A.S., and Danishefsky, S.J. 2004. The migrastatin family: Discovery of potent cell migration inhibitors by chemical synthesis. J. Am. Chem. Soc. 126: 11326-11337.

Shan, D., Chen, L., Njardarson, J.T., Gaul, C., Ma, X., Danishefsky, S.J., and Huang, X.-Y. 2005. Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proc. Natl. Acad. Sci. USA 102: 3772-3776.

Yang, S. and Huang, X.-Y. 2005. Ca2+ influx through L-type Ca2+ channels controls the trailing tail contraction in growth factor-induced fibroblast cell migration. J. Biol. Chem. 280: 27130-27137.

Sun, Y., Ma, Y.-C., Huang, J., Chen, K.Y., McGarrigle, D.K., Huang, X.-Y. 2005 Requirement of Src-family tyrosine kinases in fat accumulation. Biochemistry 44: 14455-14462.

Shan, D., Chen, L., Wang, D., Tan, Y.-C.., Gu, J.L., and Huang, X.-Y. 2006. The G protein Ga13 is required for growth factor-induced cell migration. Developmental Cell 10: 707-718.

Madhusoodanan, K.S., Guo, D., McGarrigle, D.K., Maack, T., and Huang, X.-Y. 2006. Csk mediates G protein-coupled lysophosphatidic acid receptor-induced inhibition of membrane-bound guanylyl cyclase activity. Biochemistry 45: 3396-3403.

McGarrigle, D.K., Shan, D., Yang, S., and Huang, X.-Y. 2006. Role of tyrosine kinase Csk in GPCR- and RTK-induced fibroblast cell migration. J. Biol. Chem. 281: 10583-10588.

Wang, D., Tan, Y.-c., Kreitzer, G.E., Nakai, Y., Shan, D., Zheng, Y., and Huang, X.-Y. 2006. G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles. J. Biol. Chem. 281: 32660-32667.

Sun, Y., Huang, J.J., Xiang, Y., Bastepe, M., Juppner, H., Kobilka, B.K., Zhang, J.J., and Huang, X.-Y. 2007. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J. 26: 53-64.

Guo, D., Tan, Y.-c., Wang, D., Madhusoodanan, K.S., Zheng, Y., Maack, T., Zhang, J.J., and Huang, X.-Y. 2007. A Rac -cGMP signaling pathway. Cell 128: 341-355.

Metaferia, B.B., Chen, L., Baker, H., Huang, X.-Y., and Bewley, C.A. 2007. Synthetic macrolides that inhibit breast cancer cell migration in vitro. J. Am. Chem. Soc. 129: 2434-2435.

Li, X., Tan, Y.-c., Poulose, S., Olanow, C.W., Huang, X.-Y.*, and Yue, Z.* 2007. Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson’s disease R1441C/G mutants. J. Neurochemistry 103: 238-247. (*co-corresponding authors)

McGarrigle, D. and Huang, X.-Y. 2007. Methuselah antagonist extends lifespan. Nature Chemical Biology 3: 371-372.

Sun, Y., McGarrigle, D., and Huang, X.-Y. 2007. When a G protein-coupled receptor does not couple to a G protein. Mol. Biosystems 3: 849-854.

McGarrigle, D. and Huang, X.-Y. 2007. GPCRs signaling directly through Src-family kinases. Science STKE 2007, pe35.

Snyder, M., Huang, X.-Y., and Zhang, J. J. 2008. Identification of novel direct Stat3 target genes for control of growth and differentiation. J. Biol. Chem. 283: 3791-3798.

Low, W.C., Wang, C., Pan, Y., Huang, X.-Y., Chen, J.K., and Wang, B. 2008. The decoupling of smoothened from G-alpha-I proteins has little effect on GLI3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev. Biol. 321: 188-196.

Chen, L. Zhang, J.J., and Huang, X.-Y. 2008. cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation. J. Biol. Chem. 283: 13799-13805.

Yang, S., Zhang, J.J., and Huang, X.-Y. 2009. Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell 15:
124-134.