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Research Articles | ||||||||
| Clancy, C.E., Zhu, Z. I., and Rudy, Y. "Pharmacogenetics and anti-arrhythmic drug therapy: A theoretical investigation". American Journal of Physiology. 2007. Jan;292(1):H66-75. Choe, C.U., Schulze-Bahr, E., Neu, A., Xu, J., Zhu, Z.I., Sauter, K., Bahring, R., Priori, S., Guicheney, P., Monnig, G., Neapolitano, C., Heidemann, J., Clancy, C.E., Pongs, O., Isbrandt, D. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3. Human Molelcular Genetics. 2006. 15(19):2888-902. Terrenoire*, C., Clancy*, C.E., Cormier*, J.W., Sampson, K. and R.S. Kass. "Autonomic control of cardiac action potentials; Role of potassium channel kinetics in response to sympathetic stimulation”. Circulation Research (ultrarapid communication). 2005. Mar 18;96(5):e25-3. *equal contribution Royer A., Demolombe, S., El Harchi, A., Le Quang, K., Piron, J., Toumaniantz, G., Mazurais, D., Bellocq, C., Lande, G., Terrenoire, C., Motoike, H.K., Chevallier, J., Loussouarn, G., Clancy, C.E., Escande, D., Charpentier, F. "Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity. Cardiovascular Research. 2005. Jan 1;65(1):128-37. Clancy,C.E. and R.S. Kass. “Theoretical investigation of the neuronal Na+ channel SCN1A: Abnormal gating and epilepsy.” Biophysical Journal. 2004. 86(4): 2606-14. Tateyama, M., Rivolta, I., Clancy, C.E. and Kass, R.S. Modulation of cardiac Na+ channel gating by protein kinase A in disease-linked mutations. Journal of Biological Chemistry. 2003. 278(47): 46718-46726. Clancy, C.E., Tataeyama, M., Liu, H., Wehrens, X.H.T. and Kass, R.S. Non-equilibrium gating in Cardiac Na+ channels: An original mechanism of arrhythmia. Circulation (Rapid Track). 2003:107:2233-223. Clancy, C.E., Tataeyama, M. and Kass, R.S. Novel insights into the molecular mechanisms of bradycardia-triggered arrhythmias in the Long QT-3 syndrome. Journal of Clinical Investigation. 2002:110:1251-1262. Splawski, I., Timothy, K., Tateyama, M. Clancy, C.E., Malhotra, A., Beggs,A., Cappuccio, F., Sagnella, G.A. Kass, R.S., and Keating, M.T. African sodium channel polymorphism implicated in sudden death from cardiac arrhythmias. Science. 2002:297:1333-1336. Rivolta, I., Clancy, C.E., Tateyama, M., Liu, H., Priori, S.G., and Kass, R.S. A novel LQT-3 mutation (I1768V): evidence for LQT-3 phenotypic heterogeneity. Physiological Genomics 2002:10: 191-197. Liu, H., Tateyama, M., Clancy, C.E., Abriel, H. and Kass, R.S. Channel openings are necessary but not sufficient for use-dependent block of cardiac Na+ channels by flecainide: evidence from the analysis of disease-linked mutations. Journal of General Physiology. 2002 Jul;120(1):39-51. Clancy, C.E. and Rudy, Y. A Na+ channel mutation that causes both Brugada and Long-QT syndrome phenotypes: A simulation study of mechanism. Circulation: 2002:105:1208-1213. Nuyens, D.,Stengl, M., Dugarmaa, S., Rossenbacker, T. Compernolle, V., Rudy , Y., Smits J.F., Flameng, W., Clancy , C.E., Moons, L., Vos, M.A., Dewerchin, M., Benndorf, K., Collen, D., Carmeliet, E. and Carmeliet, P. Sudden heart rate accelerations or premature beats cause life threatening arrhythmias in mice with Long-QT3 syndrome. Nature Medicine. 2001: 7:9. 1021-1027. Clancy, C.E. and Rudy, Y. Cellular consequences of HERG mutations in the Long QT Syndrome: Precursors to sudden cardiac death. Cardiovascular Research. 2001:50:2. 301-313. Clancy, C.E. and Rudy, Y. Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 1999: 400. 566-569. Clancy, C.E., Mendoza, M.G., Naismith, T.V., Kolman, M., and Egelhoff, T.E. Identification of an MHCK A-related myosin kinase in Dictyostelium. Journal of Biological Chemistry. 1997:272: (18)11812-11815. Clancy, C.E., and Frame, M. Fractal geometry of restricted sets of circle inversions. Fractals.1996:3:689-99. |
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