Physiology, Biophysics and Systems Biology (PBSB) Department.   Fall 2006. Course outline for "Cell Physiology".  

Course Title:  Cell Physiology

Course Date:   Quarters I and II : September 5, 2006 – December 12, 2006 15 weeks - 3 hours per week Tuesdays and Thursdays, 4:15 pm - 5:30 pm

Course Location:   Physiology and Biophysics Conference Room, LC-504 A/B

Course Director: Dr. Colleen Clancy , 1300 York Avenue  LC-501E, P: 212-746-6374, Email: clc7003@med.cornell.edu

Course Objectives: To familiarize first and second year students with common topics in cell physiology and to provide exposure to research areas relevant to PBSB faculty.

Course Textbooks:
Cell Physiology Source Book: A Molecular Approach
by Nicholas Sperelaki
 
Cellular Physiology
by Mordecai P. Blaustein, Mordecai P. Blaustein, Kao Joseph P. Y., Donald R. Matteson
 
 Recommended:
 Molecular Biology of the Cell
by Bruce Alberts, Julian Lewis, Alexander Johnson

Course Introduction:


Biomolecules; Cell structure:

-Cell organelles
-Cell membranes
-Compartments, electrolytes, osmosis


Cell and protein structure/function:

-Transcription, Protein synthesis, mitosis
-No lecture
-Protein Structure
-Differentiation

-Quiz 1


Membrane proteins:

-Basic thermodynamics
-Enzyme kinetics and energetics
-Ligand-receptor binding
-Trimeric G-proteins and GPCRs
-Ion channels

-Quiz 2


Cell Biophysics:

-Electrostatics and other intermolecular interactions
-Diffusion, electrodiffusion
-Resting membrane potential
-Electrical Impulses
-Hodgkin-Huxley

-Quiz 3


Cell signaling:

-Ca2+ signaling
-Phospholipid signaling  (PIP pathways)
-MAP kinase
-PKA, PKC, cAMP
-apoptosis and apoptotic signaling
-Renin-angiotensin signaling, adrenergic signaling

Quiz 4

(Clancy )




(Clancy )
(Andersen )
(Andersen)




(Blanchard )

(Boudker)
(Herzlinger )






(Christini )
(Xu )
(Niv )
(Filizola )
(Palmer )






(Mehler )
(Krogh-Madsen )
(Clancy )
(Gong )
(Christini )






(Abbott )
(TBA )
(Altan-Bonnet )
(Abbott)
(Zhu)
(Reid)

9/5




9/7
9/12
9/14




9/19
9/21
9/26
9/28

10/3




10/5
10/10
10/12
10/17
10/19

10/24




10/26
10/31
11/2
11/7
11/9

11/14




11/16
11/21
11/28
11/30
12/5
12/7

12/12