Lab Publications

Recent publications:

• Ingólfsson HI and Andersen OS.  Screening for Small Molecules' Bilayer-Modifying Potential Using a Gramicidin-Based Fluorescence Assay.  Assay Drug Dev Technol.  Epub (2010).
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• Brass LF, Akabas MH, Burnley LD, Engman DM, Wiley CA and Andersen OS.  Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs.  Acad Med.  85(4):692-701 (2010).
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• Lundbæk JA, Collingwood SA, Ingólfsson HI, Kapoor R and Andersen OS.  Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes.  J R Soc Interface.  7(44):373-95 (2010).
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• Andersen OS, Ingólfsson HI and Lundbæk JA.  Ion Channels.  In Wiley Encyclopedia of Chemical Biology.   John Wiley & Sons, Inc. (2008).
  


• Kapoor R, Kim JH, Ingólfsson HI and Andersen OS.  Preparation of artificial bilayers for electrophysiology experiments.  J Vis Exp.  (20). pii: 1033. doi: 10.3791/1033 (2008).
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• Ingólfsson HI, Kapoor R, Collingwood SA and Andersen OS.  Single molecule methods for monitoring changes in bilayer elastic properties.  J Vis Exp.  (21). pii: 1032. doi: 10.3791/1032 (2008).
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• Palmer LG and Andersen OS.  The two-membrane model of epithelial transport: Koefoed-Johnsen and Ussing (1958).  J Gen Physiol.  132(6):607-12 (2008).
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• Ashrafuzzaman M, Andersen OS and McElhaney RN.  The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels.  Biochim Biophys Acta.  1778(12):2814-22 (2008).
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• Sun H, Greathouse DV, Andersen OS and Koeppe RE II.  The preference of tryptophan for membrane interfaces: insights from N-methylation of tryptophans in gramicidin channels.  J Biol Chem.  283(32):22233-43 (2008).
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• Pugh EN Jr and Andersen OS.  Models and mechanistic insight.  J Gen Physiol.  131(6):515-9 (2008).
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• Andersen OS.  Perspectives on how to drug an ion channel.  J Gen Physiol.  131(5):395-7 (2008).
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• Andersen OS, Bruno MJ, Sun H and Koeppe RE II.  Single-molecule methods for monitoring changes in bilayer elastic properties.  Methods Mol Biol.  400:543-70 (2007).
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• Ingólfsson HI, Koeppe RE II and Andersen OS.  Curcumin is a modulator of bilayer material properties.  Biochemistry.  11;46(36):10384-91 (2007).
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• Adachi S, Nagao T, Ingólfsson HI, Maxfield FR, Andersen OS, Kopelovich L and Weinstein IB.  The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells.  Cancer Res.  67(13):6493-501. (2007).
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• Bruno MJ, Koeppe RE II and Andersen OS.  Docosahexaenoic acid alters bilayer elastic properties.  Proc Natl Acad Sci U S A.  104(23):9638-43 (2007).
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• Andersen OS and Koeppe RE II.  Bilayer thickness and membrane protein function: an energetic perspective.  Annu Rev Biophys Biomol Struct.  36:107-30 (2007).
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• Ashrafuzzaman Md, Lampson MA, Greathouse DV, Koeppe RE II and Andersen OS.  Manipulating lipid bilayer material properties using biologically active amphipathic molecules.  J. Phys.: Condens. Matter.  18:S1235-S1255 (2006).
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• Jordan JB, Shobana S, Andersen OS and Hinton JF.  Effects of glycine substitutions on the structure and function of gramicidin a channels.  Biochemistry.  45(47):14012-20 (2006).
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• Artigas P, Al'aref SJ, Hobart EA, Diaz LF, Sakaguchi M, Straw S and Andersen OS.  2,3-butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylation-independent mechanisms: the role of bilayer material properties.  Mol Pharmacol.  70(6):2015-26 (2006).
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• Allen TW, Andersen OS and Roux B.  Molecular dynamics - potential of mean force calculations as a tool for understanding ion permeation and selectivity in narrow channels.  Biophys Chem.  124(3):251-67 (2006).
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• Allen TW, Andersen OS and Roux B.  Ion permeation through a narrow channel: using gramicidin to ascertain all-atom molecular dynamics potential of mean force methodology and biomolecular force fields.  Biophys J.  90(10):3447-68 (2006).
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• Lundbæk JA, Birn P, Tape SE, Toombes GES, Søgaard RSR, Koeppe RE II, Gruner SM, Hansen AJ and Andersen OS.  Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity.  Mol. Pharm.  68:680-689 (2005).
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• Andersen OS, Koeppe RE II and Roux B.  Gramicidin channels.  IEEE Transactions in Nanobioscience  4:10-20 (2005).
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• Allen TW, Andersen OS and Roux B.  On the importance of atomic fluctuations, protein flexibility and solvent in ion permeation.  J Gen Physiol.  124: 679-690 (2004).
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• Suchyna TM, Tape SE, Koeppe RE II, Andersen OS, Sachs F, Gottlieb PA. Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature.  430(6996):235-40 (2004).
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• Liu, L., T. Yang, M.J. Bruno, O.S. Andersen and S.A. Simon.  Voltage gated ion channels in nociceptors: modulation by cGMP.  J Neurophysiol.  92:2323-2332 (2004).
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• Lundbæk JA, Birn P, Hansen AJ, Sogaard R, Nielsen C, Girshman J, Bruno MJ, Tape SE, Egebjerg J, Greathouse DV, Mattice GL, Koeppe RE II, Andersen OS. Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. J Gen Physiol.  123(5):599-621 (2004).
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• Allen TW, Andersen OS, Roux B. Energetics of ion conduction through the gramicidin channel. Proc Natl Acad Sci U S A.  101(1):117-22 (2004).
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• Hwang TC, Koeppe RE II, Andersen OS. Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics. Biochemistry.  42(46):13646-58 (2003).
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• Allen TW, Andersen OS, Roux B. Structure of gramicidin a in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data. J Am Chem Soc.  125(32):9868-77 (2003).
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• Goforth RL, Chi AK, Greathouse DV, Providence LL, Koeppe RE II, Andersen OS. Hydrophobic coupling of lipid bilayer energetics to channel function. J Gen Physiol.  121(5):477-93 (2003).
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• Lundbæk JA, Andersen OS, Werge T, Nielsen C. Cholesterol-induced protein sorting: an analysis of energetic feasibility. Biophys J.  84(3):2080-9 (2003).
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• Sham SS, Shobana S, Townsley LE, Jordan JB, Fernandez JQ, Andersen OS, Greathouse DV, Hinton JF. The structure, cation binding, transport, and conductance of Gly15-gramicidin A incorporated into SDS micelles and PC/PG vesicles. Biochemistry.  42(6):1401-9 (2003).
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• Lingappa VR, Rutkowski DT, Hegde RS, Andersen OS. Conformational control through translocational regulation: a new view of secretory and membrane protein folding. Bioessays.  24(8):741-8 (2002).
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• Jude AR, Providence LL, Schmutzer SE, Shobana S, Greathouse DV, Andersen OS, Koeppe R II. Peptide backbone chemistry and membrane channel function: effects of a single amide-to-ester replacement on gramicidin channel structure and function. Biochemistry.  40(5):1460-72 (2001).
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• Nielsen C, Andersen OS. Inclusion-induced bilayer deformations: effects of monolayer equilibrium curvature. Biophys J.  79(5):2583-604 (2000).
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• Andersen OS. Membranes, sensors and cell surfaces. Mol Membr Biol.  17(1):59-62 (2000).
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• Koeppe RE II, Hatchett J, Jude AR, Providence LL, Andersen OS, Greathouse DV. Neighboring aliphatic/aromatic side chain interactions between residues 9 and 10 in gramicidin channels. Biochemistry.  39(9):2235-42 (2000).
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• Lundbæk JA., and Andersen OS. Spring constants for channel-induced lipid bilayer deformations: estimates using gramicidin channels. Biophys. J.  76:889-895 (1999).
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• Jude AR, Greathouse DV, Koeppe RE II, Providence LL and Andersen OS. Modulation of gramicidin channel structure and function by the aliphatic "spacer" residues 10, 12 and 14 between the tryptophans. Biochemistry.  38:1030-1039 (1999).
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• Goulian M, Mesquita ON, Fygenson DK, Nielsen C, Andersen OS and Libchaber A. Gramicidin channel kinetics under tension. Biophys. J.  74:328-337 (1998).
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• Nielsen C, Goulian M and Andersen OS. Energetics of inclusion-induced bilayer deformations. Biophys. J.  74:1966-1983 (1998).
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• Mouritsen OG and Andersen OS (eds.). In Search of a New Biomembrane Model, an International symposium. Biol. Skr. Dan. Vid. Selsk.  vol. 49 (1998).


• Mouritsen OG, and Andersen OS. Do we need a new biomembrane model? Biol. Skr. Dan. Vid. Selsk.  49:7-12 (1998).


• Andersen OS, Nielsen C, Maer AM, Lundbæk JA, Goulian M and Koeppe RE II. Gramicidin channels: molecular force transducers in lipid bilayers. Biol. Skr. Dan. Vid. Selsk.  49:75-82 (1998).


• Koeppe, RE II, Killian JA, Greathouse DV and Andersen OS. Tryptophan anchors in transmembrane proteins. Biol. Skr. Dan. Vid. Selsk.  49:93-98 (1998).


• Andersen OS, Greathouse DV, Providence LL, Becker MD and Koeppe RE II. Importance of tryptophan dipoles for protein function: 5-fluorination of tryptophans in gramicidin A channels. J. Am. Chem. Soc.  120:5142-5146 (1998).
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• Andersen OS, Nielsen C, Maer AM, Lundbæk JA, Goulian M and Koeppe RE II. Ion channels as tools to monitor lipid bilayer-membrane protein interactions: Gramicidin channels as molecular force transducers. Meth. Enzymol.  294:208-224 (1999).
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• Greathouse DV, Koeppe RE II, Providence LL, Shobana S and Andersen OS. Design and characterization of gramicidin channels. Meth. Enzymol.  294:525-550 (1999).
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• Lundbæk JA, Maer AM and Andersen OS. Lipid bilayer electrostatic energy, curvature stress and assembly of gramicidin channels.Biochemistry.  36:5695-5701 (1997).
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• Andersen OS, Providence LL, Mattice GL, Koeppe RE II. Ion channels with l- and d-amino acids. ChemTractsBiochem. Mol. Biol.  10:1 75-188 (1997).


• Mobashery N, Nielsen C and Andersen OS. The conformational preference of gramicidin channels is a function of lipid bilayer thickness. FEBS Lett.  412:15-20 (1997).
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• Girshman J, Greathouse DV, Koeppe RE II and Andersen OS. Gramicidin channels in phospholipid bilayers having unsaturated acyl chains. Biophys. J.  73:1310-1319 (1997).
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• Heyer EJ, Adams DC, Wald A and Andersen OS. Electrophysiology for Anesthesiologists. Anesth. Clin. North America.  15:487-511 (1997).


• Oiki S, Koeppe RE II and Andersen OS. Voltage-dependent gramicidin channels. In Toward Molecular Biophysics of Ion Channels, M. Sokabe, A. Auerbach, and F. Sigworth, eds. Progress in Cell Research.  6:189-201, Amsterdam: Elsevier Science (1997).


• Koeppe RE II and Andersen OS. Engineering the gramicidin channel. Annu. Rev. Biophys. Biomol. Struct.  25:231-258 (1996).
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• Andersen, OS and Feldberg SW. The heterogenous collision velocity for hydrated ions in aqueous solutions is ~10⁴ cm/s. J. Phys. Chem.  100(11):4622-4629 (1996).
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• Lundbæk JA, Birn P, Girshman J, Hansen AJ and Andersen OS. Membrane stiffness and channel function. Biochemistry.  35:3825-3830 (1996).
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• Andersen OS, Saberwal G, Greathouse DV and Koeppe RE II. Gramicidin channels: a solvable membrane "protein" folding problem. Ind. J. Biochem. Biophys.  33:331-342 (1996).
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