Weill Medical College  of Cornell University
Weill Medical College  of Cornell University Cornell University
Department of Physiology and Biophysics
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Olaf S. Andersen
Recent publications

Andersen, O.S. and R.E. Koeppe II.  Bilayer thickness and membrane protein function: an energetic perspective.  Annual Reviews of Biophysics and Biomolecular Structure 36:107-130 (2007).

Andersen, O.S., M.J. Bruno, H. Sun and R.E. Koeppe II.  Single-molecule methods for monitoring changes in bilayer elastic properties.  In Methods in Membrane Lipids.  Ed. A. Dopico.  Humana Press.  Pp. 543-570 (2007).

Andersen, O.S., R.E. Koeppe II and B. Roux.  Gramicidin channels.  Versatile tools.  In: Biological Membrane Ion Channels: Dynamics, Structure, and Applications.  Eds. S.-H. Chung, O.S. Andersen and V. Krishnamurthy.  Springer, New York.  Pp. 33-80 (2007).

Ingolfsson, H.I., R.E. Koeppe II and O.S. AndersenCurcumin is a modulator of bilayer material properties.  Biochemistry 46:10384-10391 (2007).

Adachi, S., T. Nagao, H.I. Ingolfsson, F.R. Maxfield, O.S. Andersen, L. Kopelovich and I.B. Weinstein.  The inhibitory effect of (-)-epigallocatechin gallate (EGCG) on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells.  Cancer Research 67:6493-6501 (2007).

Bruno, M.J., R.E. Koeppe II and O.S. Andersen.  Docosahexaenoic acid alters bilayer elastic properties.  Proceedings of the National Academy of Sciences USA 104:9638-9643 (2007).

Jordan, J. B., Shobana S., O. S. Andersen and J. F. Hinton.  The Effects of glycine substitutions on the structure and function of gramicidin A channelsBiochemistry 45:14012-14020 (2006).

Artigas, P.I. S.J. Al’Aref, E.A. Hobart, L.F. Díaz, M. Sakaguchi, S. Straw and O.S. Andersen.  2,3 Butanedione monoxime affects CFTR channel function through phosphorylation-dependent and phosphorylation-independent mechanisms: the role of bilayer material properties.  Molecular Pharmacology 70:2015-2026 (2006).

Ashrafuzzaman, Md., M.A. Lampson, D.V. Greathouse, R. E. Koeppe II and O. S. Andersen.  Manipulating lipid bilayer material properties using biologically active amphipathic molecules.  Journal of Physics: Condensed Matter 18:S1235-S1255 (2006).

Allen, T.W., O.S. Andersen and B. Roux.  Ion permeation through a narrow channel: Using gramicidin to ascertain all-atom molecular dynamics potential of mean force methodology and biomolecular force fields.  Biophysical Journal 90:3447-3468 (2006).

Allen, T.W., O.S. Andersen and B. Roux.  Molecular dynamics – potential of mean force calculations as a tool for understanding ion permeation and selectivity in narrow channels.  Biophysical Chemistry 124:251-267 (2006).

Andersen, O.S., R.E. Koeppe II and B. Roux.  Gramicidin channels.  IEEE Transactions on Nanobioscience 4:10-20 (2005).

Lundbæk, JA, Birn P, Tape SE, Toombes GES, Søgaard RSR, Koeppe II RE, Gruner SM, Hansen AJ and Andersen OS.  Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity.  Mol. Pharm. 68:680-689 (2005).

Andersen OS, Koeppe RE II and Roux B.  Gramicidin channels.  IEEE Transactions in Nanobioscience 4:10-20 (2005).

Allen TW, Andersen OS and Roux B.  On the importance of atomic fluctuations, protein flexibility and solvent in ion permeation.  The Journal of General Physiology 124: 679-690 (2004).

Suchyna TM, Tape SE, Koeppe RE 2nd, Andersen OS, Sachs F, Gottlieb PA. Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature. 2004 Jul 8;430(6996):235-40.

Liu, L., T. Yang, M.J. Bruno, O.S. Andersen and S.A. Simon.  Voltage gated ion channels in nociceptors: modulation by cGMP.  Journal of Neurophysiology 92:2323-2332 (2004).

Lundbaek JA, Birn P, Hansen AJ, Sogaard R, Nielsen C, Girshman J, Bruno MJ, Tape SE, Egebjerg J, Greathouse DV, Mattice GL, Koeppe RE 2nd, Andersen OS. Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. J Gen Physiol. 2004 May;123(5):599-621.

Allen TW, Andersen OS, Roux B. Energetics of ion conduction through the gramicidin channel. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):117-22. Epub 2003 Dec 22. Hwang TC, Koeppe RE 2nd, Andersen OS. Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics. Biochemistry. 2003 Nov 25;42(46):13646-58.

Allen TW, Andersen OS, Roux B. Structure of gramicidin a in a lipid bilayer environment determined using molecular dynamics simulations and solid-state NMR data. J Am Chem Soc. 2003 Aug 13;125(32):9868-77.

Goforth RL, Chi AK, Greathouse DV, Providence LL, Koeppe RE 2nd, Andersen OS. Hydrophobic coupling of lipid bilayer energetics to channel function. J Gen Physiol. 2003 May;121(5):477-93.

Lundbaek JA, Andersen OS, Werge T, Nielsen C. Cholesterol-induced protein sorting: an analysis of energetic feasibility. Biophys J. 2003 Mar;84(3):2080-9.

Sham SS, Shobana S, Townsley LE, Jordan JB, Fernandez JQ, Andersen OS, Greathouse DV, Hinton JF. The structure, cation binding, transport, and conductance of Gly15-gramicidin A incorporated into SDS micelles and PC/PG vesicles. Biochemistry. 2003 Feb 18;42(6):1401-9.

Lingappa VR, Rutkowski DT, Hegde RS, Andersen OS. Conformational control through translocational regulation: a new view of secretory and membrane protein folding. Bioessays. 2002 Aug;24(8):741-8.

Jude AR, Providence LL, Schmutzer SE, Shobana S, Greathouse DV, Andersen OS, Koeppe R 2nd. Peptide backbone chemistry and membrane channel function: effects of a single amide-to-ester replacement on gramicidin channel structure and function. Biochemistry. 2001 Feb 6;40(5):1460-72.

Nielsen C, Andersen OS. Inclusion-induced bilayer deformations: effects of monolayer equilibrium curvature. Biophys J. 2000 Nov;79(5):2583-604.

Andersen OS. Membranes, sensors and cell surfaces. Mol Membr Biol. 2000 Jan-Mar;17(1):59-62.

Koeppe RE 2nd, Hatchett J, Jude AR, Providence LL, Andersen OS, Greathouse DV. Neighboring aliphatic/aromatic side chain interactions between residues 9 and 10 in gramicidin channels. Biochemistry. 2000 Mar 7;39(9):2235-42.

Lundbaek, J.A., and O.S. Andersen. Spring constants for channel-induced lipid bilayer deformations: estimates using gramicidin channels. Biophys. J. 76: 889-895, 1999.

Jude, A.R., D.V. Greathouse, R.E. Koeppe II, L.L. Providence, O.S. Andersen. Modulation of gramicidin channel structure and function by the aliphatic "spacer" residues 10, 12 and 14 between the tryptophans. Biochemistry 38: 1030-1039, 1999.

Goulian, M., O.N. Mesquita, D.K. Fygenson, C. Nielsen, O.S. Andersen, and A. Libchaber. Gramicidin channel kinetics under tension. Biophys. J. 74: 328-337, 1998.

Nielsen, C., M. Goulian, and O. S. Andersen. Energetics of inclusion-induced bilayer deformations. Biophys. J. 74:1966-1983, 1998.

Mouritsen, O.G., and O.S. Andersen (eds.). In Search of a New Biomembrane Model, an International symposium. Biol. Skr. Dan. Vid. Selsk. vol. 49: 1998.

Mouritsen, O.G., and O.S. Andersen. Do we need a new biomembrane model? Biol. Skr. Dan. Vid. Selsk. 49:7 -12, 1998.

Andersen, O.S., C. Nielsen, A.M. Maer, J.A. Lundbaek, M. Goulian, and R.E. Koeppe II. Gramicidin channels: molecular force transducers in lipid bilayers. Biol. Skr. Dan. Vid. Selsk. 49: 75-82, 1998.

Koeppe, R.E., II, J.A. Killian, D.V. Greathouse, and O.S. Andersen. Tryptophan anchors in transmembrane proteins. Biol. Skr. Dan. Vid. Selsk. 49: 93-98, 1998.

Andersen, O.S., D.V. Greathouse, L.L. Providence, M.D. Becker, and R.E. Koeppe II. Importance of tryptophan dipoles for protein function: 5-fluorination of tryptophans in gramicidin A channels. J. Am. Chem. Soc. 120: 5142-5146, 1998.

Andersen, O.S., C. Nielsen, A.M. Maer, J.A. Lundbk, M. Goulian, and R.E. Koeppe II. Ion channels as tools to monitor lipid bilayer-membrane protein interactions: Gramicidin channels as molecular force transducers. Meth. Enzymol. 294: 208-224, 1998.

Greathouse, D.V., R.E. Koeppe II, L.L. Providence, S. Shobana, and O.S. Andersen. Design and characterization of gramicidin channels. Meth. Enzymol. 294: 525-550, 1998.

Lundbaek, J.A., A.M. Maer, and O.S. Andersen. Lipid bilayer electrostatic energy, curvature stress and assembly of gramicidin channels. Biochemistry 36: 5695-5701, 1997.

Andersen, O.S., Providence, L.L., Mattice, G.L., Koeppe, R.E. II. Ion channels with l- and d-amino acids. ChemTractsBiochem. Mol. Biol. 10:1 75-188, 1997.

Mobashery, N., C. Nielsen, and O.S. Andersen. The conformational preference of gramicidin channels is a function of lipid bilayer thickness. FEBS Lett. 412: 15-20, 1997.

Girshman, J., D.V. Greathouse, R.E. Koeppe II, and O.S. Andersen. Gramicidin channels in phospholipid bilayers having unsaturated acyl chains. Biophys. J. 73: 1310-1319, 1997.

Heyer, E.J., D.C. Adams, A. Wald, and O.S. Andersen. Electrophysiology for Anesthesiologists. Anesth. Clin. North America 15: 487-511, 1997.

Oiki, S., R.E. Koeppe II, and O.S. Andersen. Voltage-dependent gramicidin channels. In Toward Molecular Biophysics of Ion Channels, M. Sokabe, A. Auerbach, and F. Sigworth, eds. Progress in Cell Research 6: 189-201, Amsterdam: Elsevier Science, 1997.

Koeppe, R. E. II and O. S. Andersen. Engineering the gramicidin channel. Annu. Rev. Biophys. Biomol. Struct. 25: 231-258, 1996.

Andersen, O.S. and S.W. Feldberg. The heterogenous collision velocity for hydrated ions in aqueous solutions is ~104 cm/s. J. Phys. Chem. 100: 46220-46229, 1996.

Lundbaek, J.A., P. Birn, J. Girshman, A.J. Hansen, and O.S. Andersen. Membrane stiffness and channel function. Biochemistry 35: 3825-3830, 1996.

Andersen, O.S., G. Saberwal, D.V. Greathouse, and R.E. Koeppe II. Gramicidin channels: a solvable membrane "protein" folding problem. Ind. J. Biochem. Biophys. 33: 331-342, 1996.

physiology@med.cornell.edu | last updated: Tuesday, March 11, 2008