Activation changes in TM1

TMX,Y GPCR TM X position TM Y position Experimental technique Change type Change value Summary of effect Reference # in ref.list
1 Rho 1.3
 n/a
 absorbtion spectrum
 polarity of environment no change
 tba 1996 Sakmar 26
1 Rho 1.54
 n/a
 SDSL EPR
 mobility small
 effect smaller than in TM2 1999 Hubbell 2
1 Rho 1.55
 n/a
 accessibility to DTT
 accessibility up
 no signif. change 1999 Khorana 1
1 Rho 1.55
 n/a
 SDSL EPR
 mobility small
 effect smaller than in TM2 1999 Hubbell 2
1,8 Rho 1.56
 H8
 SDSL EPR
 distance up 3A
 increase 2001 Hubbell 6
1 Rho 1.56
 n/a
 accessibility to DTT
 accessibility down
 no signif. change 1999 Khorana 1
1 Rho 1.56
 n/a
 SDSL EPR
 mobility small
 effect smaller than in TM2 1999 Hubbell 2
1,8 Rho 1.57
 H8
 SDSL EPR
 distance up 4A
 increase 2001 Hubbell 6
1 Rho 1.57
 n/a
 accessibility to DTT
 accessibility up
 slight increase, maybe due to TM2 1999 Khorana 1
1 Rho 1.57
 n/a
 SDSL EPR
 mobility small
 effect smaller than in TM2 1999 Hubbell 2
1 Rho 1.58
 n/a
 accessibility to DTT
 accessibility up
 no signif. change 1999 Khorana 1
1 Rho 1.58
 n/a
 SDSL EPR
 mobility small
 effect smaller than in TM2 1999 Hubbell 2
1 Rho 1.59
 n/a
 accessibility to DTT
 accessibility down
 no signif. change 1999 Khorana 1
1 Rho 1.59
 n/a
 SDSL EPR
 mobility small
 effect smaller than in TM2 1999 Hubbell 2
1,7 Rho 1.6
 7.53
 SDSL EPR
 distance up
306 sc or bb kicked by TM6 move 2001 Hubbell 5
1,8 Rho 1.6
 H8
 SDSL EPR
 distance up
 TM1 - H8 distance increases 1996 Khorana 4
1,8 Rho 1.6
 H8
 SDSL EPR
 distance up 4A
 310 sc or bb kicked by TM6 move 2001 Hubbell 5
1,8 Rho 1.6
 H8
 SDSL EPR
 distance no change or up
 no signif. change 2001 Hubbell 5
1,8 Rho 1.6
 H8
 SDSL EPR
 distance up 1A
 no signif. change 2001 Hubbell 5
1,8 Rho 1.6
 H8
 SDSL EPR
 distance up 1A
 no signif. change 2001 Hubbell 5
1,8 Rho 1.6
 H8
 SDSL EPR
 distance up 1A
 no signif. change 2001 Hubbell 5
1,8 Rho 1.6
 H8
 SDSL EPR
 distance no change
 no signif. change 2001 Hubbell 5
1,8 Rho 1.6
 H8
 SDSL EPR
 distance no change
 no signif. Change 2001 Hubbell 6
1,8 Rho 1.6
 H8
 disulfide bond
 individual and straightjacketed Rho activates transducin <7a ca distance
 CA distance < 7A 2000 Oprian 8
1 Rho 1.6
 n/a
 accessibility to DTT
 accessibility up
 no signif. change 1999 Khorana 1
1 Rho 1.6
 n/a
 SDSL EPR
 mobility small
 effect smaller than in TM2 1999 Hubbell 2
1,2 CCR5 all
 all
 deletion
 expr. And function no change
 TM1 and TM2 not essential 1999 Pei 3
1,2 CXCR4 all
 all
 deletion
 expr. And function no change
 TM1 and TM2 not essential 2000 Pei 3
all Rho all
 all
 rotational correlation time
 change in volume or shape expansion or shape change
 expansion or shape change 2002 Heyn 22